Results 41 to 50 of about 156,220 (265)

Efficiency of Attraction to Administrative Responsibility for Providing Financial Support to Terrorism

Сибирское юридическое обозрение, 2017
The effectiveness of bringing to administrative responsibility for providing financial support to legal entities in the Russian Federation is discussed. The analysis of Russian financial monitoring's (Rusfinmonitoring) work on bringing legal entities to ...
Viktor V. Yunusov
doaj   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

SECURITY AND FINANCIAL ASPECTS OF THE DOCTRINAL AND LEGAL CHARACTERISTICS TYPES OF ADMINISTRATIVE LIABILITY OF THE SERVICEMEN OF THE ARMED FORCES OF UKRAINE

Baltic Journal of Economic Studies
The article's primary focus is on the doctrinal and legal characteristics of the types of administrative responsibility of servicemen of the Armed Forces of Ukraine, with a particular emphasis on the security and financial aspects.
Liubov Bila-Tiunova, Hanna Sarybaieva, Tetiana Holoiadova   +2 more
doaj   +1 more source

On The Issue of the Categorization of Administrative Offences

Сибирское юридическое обозрение, 2019
Some problems of modern administrative-tort and criminal legislation and law are considered. On the positive side, the sequence of the legislator is assessed regarding the delimitation of the norms of criminal and administrative responsibility. Attention
V. I. Surgutskov
doaj   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

The doctrinal understanding of the principles Institute of administrative responsibility

Хабаршы. Заң сериясы, 2016
The problem of doctrinal understanding of the principles of the Institute of administrative responsibility. Doctrinal interpretation of the principles of law presented in the paradigm of the classical theory of law and legal postnonclassical ...
Baisalova G.T.
doaj  

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

RESPONSIBILITY FOR VIOLATIONS OF THE REQUIREMENTS FOR OBTAINING AND GROWING GENETICALLY MODIFIED CROPS AND THE TURNOVER OF PRODUCTS OBTAINED WITH THEIR USE AS GIVEN IN A NEW PROJECT OF THE CODE OF THE RUSSIAN FEDERATION ON ADMINISTRATIVE OFFENSES

Гуманитарные и юридические исследования, 2021
The relevance of this article is due to its theoretical and practical significance. The theoretical significance of the study of administrative responsibility for violations of the requirements for obtaining and growing genetically modified crops and the
A. Sokolov, O. Lakaev
doaj  

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

To the Question of the Codification of the Norms on Administrative Responsibility for Violating the Legislation on the Educationof the Russian Federation

Сибирское юридическое обозрение, 2018
The article discusses the need for codification of rules on administrative responsibility for violation of the legislation of the Russian Federation on education, since these rules are contained in the Code of the Russian Federation on administrative ...
L. V. Krestinskaya
doaj   +1 more source