Results 51 to 60 of about 1,269,140 (303)

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

An Overview on Institutionalism and Decentralized Decision-Making [PDF]

, 2011
Human actions, interactions and decisions should have a certain degree of predictability that can be obtained by establishing rules. Institutions, in general, are defined by sets of rules known by the public and applicable for the community.
Forsberg, Michael, Johnson, Heather M., Reichart, Letitia, Vrtiska, Mark P.   +3 more
core   +3 more sources

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Improvement of Legislation on Administrative Responsibility for the Illegal Use of Trademarks and Application Practice

Vestnik Omskoj Ûridičeskoj Akademii, 2012
The article deals with the issues of legislation improvement concerning administrative responsibility for illegal use of trademarks. The author exposes problematic questions of law enforcement on bringing to administrative responsibility under Art. 14.10
Permyakova N. A.
doaj   +2 more sources

Efficiency of Attraction to Administrative Responsibility for Providing Financial Support to Terrorism

Сибирское юридическое обозрение, 2017
The effectiveness of bringing to administrative responsibility for providing financial support to legal entities in the Russian Federation is discussed. The analysis of Russian financial monitoring's (Rusfinmonitoring) work on bringing legal entities to ...
Viktor V. Yunusov
doaj   +1 more source

The Malaise of the Administrative Process [PDF]

, 1962
Computer viruses uses a few different techniques, with various intentions, toinfect files. However, what most of them have in common is that they wantto avoid detection by anti-malware software.
Arding, Petter, Hedelin, Hugo
core   +3 more sources

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

SECURITY AND FINANCIAL ASPECTS OF THE DOCTRINAL AND LEGAL CHARACTERISTICS TYPES OF ADMINISTRATIVE LIABILITY OF THE SERVICEMEN OF THE ARMED FORCES OF UKRAINE

Baltic Journal of Economic Studies
The article's primary focus is on the doctrinal and legal characteristics of the types of administrative responsibility of servicemen of the Armed Forces of Ukraine, with a particular emphasis on the security and financial aspects.
Liubov Bila-Tiunova, Hanna Sarybaieva, Tetiana Holoiadova   +2 more
doaj   +1 more source

A közigazgatási jogi felelősség- és szankciórendszer elméleti-dogmatikai rendszerének fejlesztési lehetőségei = New developments in the theoretical-dogmatic system of sanctions in the administrative law [PDF]

, 2007
A kutatás a közigazgatási jogi felelősségi és szankciórendszert két egymást kiegészítő rendszer egységeként kezeli. Vizsgáltuk kontinentális nemzeti és a szupranacionális közigazgatási szankciókat.
Barabás, Gergely, Fazekas, Marianna, Nagy, Marianna   +2 more
core  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source