Results 71 to 80 of about 1,269,140 (303)

RIPK4 function interferes with melanoma cell adhesion and metastasis

open access: yesMolecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski   +9 more
wiley   +1 more source

Differentiating of administrative and criminal misconducts [PDF]

open access: yes, 2011
Стаття присвячена правовій проблемі розмежування адміністративних і кримінальних проступків, яка тягне за собою реформування відповідних галузей. Було досліджено інститут адміністративної відповідальності та критерії його розмежування з інститутом ...
Dovgeyko, O. S.   +1 more
core  

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

To the Question of Administrative Responsibilityfor Vagrancy and Begging

open access: yesСибирское юридическое обозрение, 2017
The article deals with the issues of modern administrative and legal regulation of counteraction to such antisocial phenomena as vagrancy and begging.
Oleg A. Dizer
doaj   +1 more source

Tertiary education: a quick guide to key internet links [PDF]

open access: yes
This Quick Guide provides key internet links to information about: general tertiary education resources, higher education, vocational education and training (VET), international students, adult and community education, and international organisations ...
Carol Ey
core  

Адміністративно-правові аспекти захисту інформації з обмеженим доступом в Україні, Російській Федерації і Казахстані [PDF]

open access: yes, 2006
Досліджуються порушення в сфері захисту інформації з обмеженим доступом, за які передбачена адміністративна відповідальність.Under research are delicts in data protection sphere that entail administrative ...
Макаренко, Альона   +1 more
core  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

АДМИНИСТРАТИВНАЯ ОТВЕТСТВЕННОСТЬ ЮРИДИЧЕСКИХ ЛИЦ: ПРАВОВЫЕ ОСОБЕННОСТИ

open access: yesХабаршы. Заң сериясы, 2019
In article are considered features of administrative responsibility of legal bodies in the light of the modern administrative legislation, the remedial problems connected with attraction of the legal person to administrative responsibility rise.
G.T. Baysalova
doaj  

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Administrative Responsibility for Offenses in Economic Areas

open access: yesСибирское юридическое обозрение, 2020
Relations in economic areas is a special sphere of social relations, which is associated with the phenomenon of ownership and which are regulated by civil, budget, tax, customs legislation and others.
M. N. Kobzar-Frolova
doaj  

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