Results 161 to 170 of about 6,990 (302)

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

open access: yesFEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner   +7 more
wiley   +1 more source

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

open access: yesFEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento   +6 more
wiley   +1 more source

Irish financial regulatory enforcement: reforming the criminal law and administrative sanction interplay strategy

open access: yes, 2014
The empirical genesis for this novel inter-disciplinary dissertation was the devastating global financial crisis. A separate and simultaneous Irish crisis was located in the banking sector.
Elder, Shaun, Shaun Elder (12601600)
core   +1 more source

Institutional Requirements for Effective Imposition of Fines [PDF]

open access: yes
A long theoretical literature in economics addresses the heavy reliance of the U.S. criminal justice system on very expensive forms of punishment – prison – when cheaper alternatives – such as fines and other sanctions – are available.
Anne Morrison Piehl, Geoffrey Williams
core  

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

open access: yesFEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin   +12 more
wiley   +1 more source

The element of fault in the cases of administrative liability and service liability.

open access: yes, 2009
Summary The Element of Fault in the Cases of Administrative Liability and Service Liability The beginning of the legal liability is the violation of law; the end of the restriction of rights of the violator of law.
Pūtienė, Galina,
core  

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