Results 41 to 50 of about 328,197 (308)

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Are We Done Waiting?

, 2020
**Trigger warning: sexual assault In the past month students in surrounding colleges have been protesting and challenging administrative policies regarding sexual assault, yet many of us at Gettysburg are unaware of these events.
Mercer, Katie F.
core  

Recognizing Destabilization in the Individual Health Insurance Market [PDF]

, 2010
Presents experts' views on how healthcare reform's new rules on how much of insurers' premiums pay for healthcare services and clinical quality will affect premiums, coverage, and availability.
Jill Bernstein
core  

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Developments Under the Freedom of Information Act [PDF]

, 1972
This article reviews authors' recently developed algorithm for identification of nonlinear state-space models under missing observations and extends it to the case of unknown model structure.
Gopaluni, Bhushan, Schön, Thomas, Wills, Adrian   +2 more
core   +2 more sources

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Vidy sistematizatsii rossiiskogo zakonodatel'stva (Types of systematization of the Russian legislation)

Russian Journal of Economics and Law, 2014
Objective: to examine measures of administrative coercion applied to the media; to justify the need for changes to Articles 4 and 16 of the Law on mass media.
I. Y. Gol’Tyapina
doaj  

Isolation and identification of antagonistic fungi for biocontrol of Impatiens hawkeri leaf spot disease and their growth-promoting potential

Frontiers in Microbiology
Impatiens hawkeri, a plant of great horticultural significance with high ornamental and economic value, is frequently afflicted by leaf spot disease caused by Stagonosporopsis cucurbitacearum, and effective biological control methods for this disease are
Huali Li, Huali Li, Mingguo Yang, Mingguo Yang, Jian Liu, Jian Liu, Yajiao Sun, Yajiao Sun, Huajun Yang, Junjia Lu   +9 more
doaj   +1 more source