Results 61 to 70 of about 165,119 (267)

La arquitectura de tierra de Mesoamérica

Anales del Instituto de Arte Americano e Investigaciones Estéticas "Mario J. Buschiazzo", 2018
Hasta el momento la evidencia arqueológica que demuestra la existencia de una vigorosa y milenaria arquitectura monumental de tierra en la zona mesoamericana, ha sido poco estudiada y por lo tanto permanece ignorada. Esta precede y forma el prototipo de
Annick Daneels
doaj  

Paisaje y diseño en torno a la construcción del templo de San Miguel Arcángel, Santo Domingo de Heredia, Costa Rica, 1879

Cuadernos Inter.c.a.mbio sobre Centroamérica y el Caribe, 2018
Este documento analiza los elementos del paisaje y del diseño alrededor de la construcción del templo patrimonial El Carmen (anterior ermita de San Miguel) durante el siglo XIX en Santo Domingo de Heredia, Costa Rica. Se utilizan las teorías del diseño y
Henry O. Vargas Benavides
doaj   +1 more source

Human Dental Pulp Stem Cell Secretome Restores Ischemic Stroke–Impaired Motor and Cognitive Functions by Reprogramming Redox and Inflammatory Signaling

Advanced Science, EarlyView.
Human dental pulp stem cell secretome emerges as a cell‐free therapeutic strategy for ischemic stroke by reprogramming redox and inflammatory signaling. hDPSC secretome‐derived antioxidant and immunomodulatory factors suppress the TLR4–NOX–ROS–NF‐κB axis, reduce microglial inflammatory responses and apoptosis, and promote neurogenesis, angiogenesis ...
Kyung‐Joo Seong, Sehoon Park, Sun‐Woong Bae, Daseul Kim, Jin Ho Lee, Won‐Seok Choi, Zee‐Yong Park, Ji‐Yeon Jung, Won‐Jae Kim   +8 more
wiley   +1 more source

A Blood‐Derived Factor Rescues ALS: Platelet Factor 4 Activates OPTN‐Dependent Autophagy to Clear SOD1 Aggregates Independently of PINK1

Advanced Science, EarlyView.
Systemic platelet factor 4 (PF4) is significantly depleted in amyotrophic lateral sclerosis (ALS). Peripheral PF4 replenishment restores central proteostasis by driving OPTN‐dependent, PINK1‐independent selective autophagy in motor neurons. This intervention effectively clears toxic SOD1 aggregates, blunts glial activation, and preserves neuromuscular ...
Qingjian Xie, Yanbo Zhu, Wenhua Jiang, Haobo Xie, Yaojia Li, Mengjie Hu, Kezheng Li, Huan Yu, Yixuan Pan, Chaoyi Jiang, Xueqin Song, Dongsheng Fan, Binbin Deng   +12 more
wiley   +1 more source

The Use of Steatite Powder Waste as an Aggregate for the Manufacture of Earth Blocks—An Evaluation of Its Impact on Physical, Mechanical and Thermal Conductivity Properties

Buildings
Earthen construction is a sustainable alternative to conventional building materials due to its low environmental impact; however, both its mechanical strength and durability differ from conventional building materials.
Carlos Alberto Casapino-Espinoza, José Manuel Gómez-Soberón, María Consolación Gómez-Soberón   +2 more
doaj   +1 more source

La tecnología de construcción con tierra en la conformación del paisaje de frontera del Estado-Nación argentino durante el siglo XIX y principios del XX

Anales del Instituto de Arte Americano e Investigaciones Estéticas "Mario J. Buschiazzo", 2022
La preocupación sobre el control y expansión de la frontera interna adquirió centralidad en el Estado-nación argentino desde el momento de su independencia.
Guillermo Rolón, Carola Herr, Ángela Sánchez Negrette   +2 more
doaj  

Single‐Atom‐Enhanced Fully Inkjet‐Printed Electrochemical Sensor for Dopamine Detection

Advanced Science, EarlyView.
Fully inkjet‐printed paper‐based dopamine sensors are fabricated using nitrogen‐doped graphene acid functionalized with copper single atoms. The copper sites uniquely enhance dopamine oxidation through strong molecular adsorption, as verified by electrochemical measurements and DFT calculations. The approach highlights the potential of single‐atom inks
Martin‐Alex Nalepa, David Panáček, Vítězslav Hrubý, Matěj Jendrišák, Rostislav Langer, Michal Langer, Petr Jakubec, Ivan Dědek, Vojtěch Kupka, Michal Mazur, Radek Zbořil, Michal Otyepka   +11 more
wiley   +1 more source

Review of Gastrointestinal Capsule Robots: Materials, Actuation, Diagnostics, and Therapeutics

Advanced Science, EarlyView.
This review examines gastrointestinal capsule robots through a systems engineering lens, covering shell materials, actuation and localization strategies, diagnostic modalities, therapeutic interventions, and commercialization status. By mapping the complete technological chain from fabrication to clinical deployment, this work identifies critical gaps ...
Zengsheng Li, Zhongguo Ren, Yiliang Lin, Xianfeng Xia, Tianlong Li, Kai Fung Chan, Philip Wai Yan Chiu, Wei Peng Yong, Mengmeng Sun   +8 more
wiley   +1 more source

System Architecture and Prospective Evaluation Protocol of AskDoc: A Secure Multimodal mHealth Triage Assistant — Pilot Safety and Feasibility Study

Applied Medical Informatics
Aim: This study is explicitly designed as a feasibility and safety pilot, not a powered efficacy trial. Its dual purpose is: (i) to establish whether an AI-augmented, rule-constrained triage strategy can reduce clinically unsafe under-triage compared ...
Hema MADHAV, Vivin RAJAGOPALAN
doaj  

A Novel Pak1 Activator Ameliorates ER Stress for HFpEF Therapy

Advanced Science, EarlyView.
Chronic metabolic stress is a major contributor to HFpEF progression. Under prolonged metabolic stress, Pak1 activity becomes impaired, contributing to disrupted ER proteostasis, cardiomyocyte apoptosis, fibrosis, and diastolic dysfunction. Mechanistically, Pak1 overexpression activates the ERK1/2–MNK1–eIF4E signaling axis, promotes translational ...
Honglin Xu, Hongyuan Zhang, Tayyiba Azam, Susanne S. Hille, Yingjuan Liu, Min Zi, Jiaqing Lang, He Yu, Yujia Cao, Bernard D. Keavney, Tamer M. A. Mohamed, Jessica M. Miller, Riham R. E. Abouleisa, Ming Xu, Elizabeth J. Cartwright, Oliver J. Müller, Ming Lei, Xin Wang   +17 more
wiley   +1 more source