Results 81 to 90 of about 278,726 (308)

Low‐Intensity Ultrasound‐Triggered Microbubble Cavitation Attenuates Diabetic Kidney Injury Partially by Reversing Endothelial Dysfunction

Advanced Science, EarlyView.
Non‐invasive low‐intensity pulsed ultrasound ‐triggered cavitation of clinically approved diagnostic‐grade microbubbles delivers favorable mechanical stimuli to renal microvasculature. This intervention restores renal microvascular homeostasis, alleviates DKD‐associated histological and functional damage, and suppresses inflammatory and fibrotic ...
Yubo Lai, Liang Zhang, Wenxin Tao, Jieyuan An, Lantian Wang, Zhaoyou Liu, Guodong Yang, Pengying Wu, Lijun Yuan   +8 more
wiley   +1 more source

System Architecture and Prospective Evaluation Protocol of AskDoc: A Secure Multimodal mHealth Triage Assistant — Pilot Safety and Feasibility Study

Applied Medical Informatics
Aim: This study is explicitly designed as a feasibility and safety pilot, not a powered efficacy trial. Its dual purpose is: (i) to establish whether an AI-augmented, rule-constrained triage strategy can reduce clinically unsafe under-triage compared ...
Hema MADHAV, Vivin RAJAGOPALAN
doaj  

The Use of Steatite Powder Waste as an Aggregate for the Manufacture of Earth Blocks—An Evaluation of Its Impact on Physical, Mechanical and Thermal Conductivity Properties

Buildings
Earthen construction is a sustainable alternative to conventional building materials due to its low environmental impact; however, both its mechanical strength and durability differ from conventional building materials.
Carlos Alberto Casapino-Espinoza, José Manuel Gómez-Soberón, María Consolación Gómez-Soberón   +2 more
doaj   +1 more source

La tecnología de construcción con tierra en la conformación del paisaje de frontera del Estado-Nación argentino durante el siglo XIX y principios del XX

Anales del Instituto de Arte Americano e Investigaciones Estéticas "Mario J. Buschiazzo", 2022
La preocupación sobre el control y expansión de la frontera interna adquirió centralidad en el Estado-nación argentino desde el momento de su independencia.
Guillermo Rolón, Carola Herr, Ángela Sánchez Negrette   +2 more
doaj  

Dual‐Dynamically Crosslinked Nanogels Enable Prolonged Ocular Retention for Multimodal Dry Eye Therapy [PDF]

Advanced science
This berberine‐loaded dual‐dynamically crosslinked nanogel integrates tannic acid‐zinc metal‐phenolic networks and carboxymethyl chitosan/aldehyde‐functionalized poly(ethylene glycol) dynamic Schiff base networks, achieving 1‐year colloidal and antioxidant stability, sustained corneal berberine exposure for 24 h to support convenient once‐daily dosing,
Xin Y, Chen S, Huang S, Huang M, Zhu J, Wang Z, Shen J, Zheng Q.   +7 more
europepmc   +2 more sources

A Multi‐Targeting Chimeric Antigen Receptor‐T Cell Platform to Overcome Antigen Heterogeneity in the Treatment of Non‐Small Cell Lung Cancer

Advanced Science, EarlyView.
A dual‐transmembrane Bicephali CAR‐T platform simultaneously targets CD276 and NKG2D ligands to address antigen heterogeneity in non‐small cell lung cancer. By improving immune synapse formation, mitochondrial fitness, antioxidant capacity, and stem‐like persistence, this design enhances durable tumor control and provides a versatile strategy to ...
Lina Wang, Yanlei Zhang, Shuixiu Peng, Chenchen Hou, Huaqi Guo, Tianyu Zhou, Alex H. Chang, Lifeng Yan, Weining Xiong   +8 more
wiley   +1 more source

RAG-GenomicSumm: A Retrieval-Augmented Generation Framework for Plain-Language Summarization of Clinical Genomic Reports via an Event-Driven Microservices Pipeline

Applied Medical Informatics
Clinical genomic reports generated from next-generation sequencing contain dense technical terminology poorly understood by non-specialist clinicians, genetic counselors, and patients.
Vivin RAJAGOPALAN, Hema MADHAV
doaj  

Neonatal Sevoflurane Exposure Induces Long‐Term Cognitive Impairment via Epigenetically Mediated MMP9 Activation and Perineuronal Net Disruption in the Hippocampal CA2

Advanced Science, EarlyView.
Hippocampal CA2 perineuronal nets ensheathing excitatory pyramidal neurons are selectively vulnerable to repeated neonatal sevoflurane exposure. Epigenetic upregulation of MMP9 via reduced H3K27me3 disrupts PNN integrity, impairs BDNF–TrkB signaling, and causes synaptic protein loss and dendritic spine deficits, leading to persistent social and spatial
Lirong Liang, Jiachen Wang, Taozhi Wang, Yanling Li, Youyi Zhao, Guanghui Hao, Peiqin Gong, Ruling Chen, Yilin Fang, Shengxi Wu, Haopeng Zhang, Hui Zhang   +11 more
wiley   +1 more source

A Biomimetic Solvatochromic Chip With Optimized Chemical Diversity for On‐Site Liquid Identification

Advanced Science, EarlyView.
A compact biomimetic photonic‐gustatory chip uses Hansen‐solubility‐parameter‐guided solvatochromic disks to create distinct color patterns in organic liquids. An optimized four‐disk array distinguishes solvent types, ratios, homologues, isomers, and alcoholic beverages. Coupled with smartphone imaging and deep learning, it identifies 80 liquid classes
Jintao Zhang, Hao Ouyang, Yin Cheng, Nuoye Xiong, Xunchi Ma, Xueling Li, Guangming Zhu, Liang Zhang, Jing Sun, Ranran Wang   +9 more
wiley   +1 more source

Leveraging Life Cycle Cost Analysis (LCCA) for Optimized Decision Making in Adobe Construction Materials

Applied Sciences
Adobe construction is a longstanding practice in South America and is characterized by its affordability, accessibility, and ecological sustainability.
Jorge Albuja-Sánchez, Andreina Damián-Chalán   +1 more
doaj   +1 more source