Results 141 to 150 of about 872,005 (359)

Adolescent alcohol binge-drinking induces delayed appearance of behavioral defects in mice [PDF]

open access: gold, 2020
Laura Van Hees   +7 more
openalex   +1 more source

Acetylation Regulates ACSL4 Degradation Through Chaperone‐Mediated Autophagy to Alleviate Intervertebral Disc Degeneration

open access: yesAdvanced Science, EarlyView.
Intervertebral disc degeneration is triggered by ACSL4 accumulation‐mediated ferroptosis of nucleus pulposus cells due to CMA dysfunction. KAT2B promotes ACSL4 degradation via CMA through acetylation. AAV‐mediated LAMP2A delivery or engineered exosomes rescue nucleus pulposus cell senescence and disc degeneration.
Zhouwei Wu   +10 more
wiley   +1 more source

Relationship between social anxiety and sleep quality in depressed adolescents: the mediating role of internet addiction

open access: yesFrontiers in Psychiatry
ObjectiveThis study investigated the association between social anxiety and sleep quality and further explored the potential mediating role of internet addiction in depressed adolescents.MethodsThis study included 440 Chinese depressed adolescents (mean ...
Yifan Ma   +5 more
doaj   +1 more source

Sluggish Cognitive Tempo among Iranian Children and Adolescents: A Validation Study of the Farsi Child and Adolescent Behavior Inventory (CABI)-Parent Version. [PDF]

open access: yesJ Clin Med, 2022
Sadeghi-Bahmani D   +8 more
europepmc   +1 more source

Tobacco Smoke Exposure From Prenatal To Adolescent Periods Drives IBD Pathogenesis: Dynamic DNA Methylation Signatures Across Lifespan Stages

open access: yesAdvanced Science, EarlyView.
This study illustrates that maternal smoking during pregnancy (MSDP) is an independent risk factor for IBD in offspring, and DNA methylation serves as a key mechanistic pathway connecting early‐life smoking exposure with IBD risk in offspring. That highlights the urgent need for preventive interventions targeting prospective parents and minors to ...
Han Zhang   +11 more
wiley   +1 more source

The Association Between Parental Phubbing and Preschoolers’ Excessive Electronic Media Use: The Chain Mediating Role of Parent–Child Attachment and Self-Control

open access: yesBehavioral Sciences
In the current digital age, children are exposed to electronic media at an increasingly early age. The issue of excessive electronic media use has become a significant risk factor affecting the healthy development of young children.
Qiong Zhao   +4 more
doaj   +1 more source

Tumor Extracellular Vesicles lncOSLMT Drives Lung Inflammatory Premetastatic Niche Formation in Osteosarcoma via m6A‐Dependent hnRNPA2B1/COX‐2 Axis

open access: yesAdvanced Science, EarlyView.
Tumor‐derived extracellular vesicles program inflammatory lung premetastatic niches through selective delivery of long noncoding RNAs. This work reveals EVs‐associated lncOSLMT as a key driver of lung fibroblast activation via m6A‐dependent PTGS2 stabilization.
Hongbo Li   +10 more
wiley   +1 more source

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