Results 71 to 80 of about 346,568 (317)

RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu, Xin Duan, Fatemeh Peymani, Jia Wang, Chengjia Bao, Chaolong Xu, Ying Zou, Zixuan Zhang, Yunxi Zhang, Tongyue Li, Martin Pavlov, Junling Wang, Minhan Song, Tianyu Song, Xiaodi Han, Mingxi Sun, Danmin Shen, Ruoyu Duan, Huafang Jiang, Manting Xu, Holger Prokisch, Fang Fang   +21 more
wiley   +1 more source

How do different perceived school goal structures affect Chinese kindergarten teachers’ professional identity? The role of basic psychological needs satisfaction and growth mindset

Frontiers in Psychology
IntroductionDue to the unique challenges and high-intensity emotional labor in their work, kindergarten teachers’ high levels of job burnout and turnover rate have become a widely recognized social issue.
Wei Luo, Xingcan Ni, Chundie Wang, Jiaqin Wang, Yujia Zeng, Chengfu Yu   +5 more
doaj   +1 more source

Childhood IQ and adolescent health behavior

This study investigates whether cognitive ability in early childhood predicts adolescent health-related and risky behaviors, independent of schooling and socioeconomic background.
Khanam, Rasheda, Jurges, Hendrik
core   +1 more source

Sertraline Treatment Can Mimic Niemann‐Pick Type C Biomarker Profile: A Diagnostic Pitfall

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Oxysterols (cholestane‐3β,5α,6β‐triol and 7‐ketocholesterol) and N‐palmitoyl‐O‐phosphocholineserine (PPCS) are sensitive biomarkers for Niemann‐Pick disease type C (NPC) screening. However, false‐positive results occur, with a biomarker profile suggestive of NPC despite the absence of pathogenic variants in genes involved in NPC or ...
Maria Makrygianni, Cecile Pagan, Antony Citterio‐Quentin, Isabelle Rouvet, Giulia Dingeo, Cyril Hanin, Claudine Laurent‐Levinson, Samia Pichard, Bénédicte Héron, Clément Gourguechon, Daniele Mandia, Jerome Guitton, Carole Lacout, Nicolas Schleinitz, Florient Potier, Olivier Flabeau, Elsa Besse‐Pinot, Foudil Lamari, Magali Pettazzoni, Yann Nadjar   +19 more
wiley   +1 more source

The Longitudinal Association Between Internet Addiction and Prosocial Behavior Among Chinese Adolescents: Testing a Moderated Mediation Model

Behavioral Sciences
Internet addiction has been associated with decreased prosocial behavior in adolescents, and minority studies have investigated the underlying mechanisms involved.
Wei-Xuan Liang, Wan-Yu Ye, Kai-Xin Ng, Kai Dou, Zhi-Jun Ning   +4 more
doaj   +1 more source

Chinese public’s knowledge, perceived severity, and perceived controllability of COVID-19 and their associations with emotional and behavioural reactions, social participation, and precautionary behaviour: a national survey

BMC Public Health, 2020
Background The outbreak of the coronavirus disease-19 (COVID-19) has caused enormous stress among the public in China. Intellectual input from various aspects is needed to fight against COVID-19, including understanding of the public’s emotion and ...
Jian-Bin Li, An Yang, Kai Dou, Lin-Xin Wang, Ming-Chen Zhang, Xiao-Qi Lin   +5 more
doaj   +1 more source

Electroencephalographic Normalization as a Biomarker of Clinical Recovery in Down Syndrome Regression Disorder

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Down syndrome regression disorder is a syndrome characterized by subacute loss of cognitive, behavioral, and functional abilities in individuals with Down syndrome. Electroencephalography abnormalities are frequently observed during evaluation, but it remains unclear whether these findings represent a dynamic marker of disease ...
Jonathan D. Santoro, Mackenzie Silverman, Maeve C. Lucas, Mariam M. Yousuf, Samuel T. Otey, Stella V. Gray, Brittany Jordan, Madeline D. Kahan, Latanya D. Agurs, Michelle Van Hirtum Das, Deborah Holder, Devin King, Eileen A. Quinn, Ryan Kammeyer, Michael S. Rafii   +14 more
wiley   +1 more source

Childhood Unpredictability and Smartphone Addiction in Chinese Adolescents: Mediating Role of Self-Concept Clarity and Self-Control and Moderating Role of Psychological Resilience

Behavioral Sciences
As a distal factor influencing adolescents’ psychological development and behavioral adaptation, the question of whether and how childhood unpredictability is associated with smartphone addiction remains unclear.
Qingqing Li, Mingyang Zhang, Hailan Wang, Wenjing Liu, Yanjing Wang, Zhuoran Li, Zhenrong Fu   +6 more
doaj   +1 more source

Review of clinical studies of perampanel in adolescent patients

, 2017
Aim: To assess the clinical trial and real-world data for adjunctive perampanel in adolescents and develop consensus recommendations to guide the use of perampanel in this population in clinical practice.
Kim, Heung Dong;Chi, Ching-Shiang;Desudchit, Tayard;Nikanorova, Marina;Visudtibhan, Anannit;Nabangchang, Charcrin;Chan, Derrick W. S.;Fong, Choong Yi;Chang, Kai-Ping;Kwan, Shang-Yeong;De Los Reyes, Fe;Huang, Chao-Ching;Likasitwattanakul, Surachai;Lee, Wang-Tso;Yung, Ada;Dash, Amitabh, 李旺祚   +1 more
core   +1 more source

Cognitive Behavioral Therapy for Youth With Childhood‐Onset Lupus: A Randomized Clinical Trial

Arthritis Care &Research, EarlyView.
Objective Our objective was to determine the feasibility and acceptability of the Treatment and Education Approach for Childhood‐Onset Lupus (TEACH), a six‐session cognitive behavioral intervention addressing depressive, fatigue, and pain symptoms, delivered remotely to individual youth with lupus by a trained interventionist.
Natoshia R. Cunningham, Thea Senger‐Carpenter, Jocelyn Zuckerman, Michelle Adler, Mallet R. Reid, Ashley Danguecan, Luana Flores Pereira, Sarah I. Mossad, Samantha L. Ely, Khalid Abulaban, Elizabeth A. Kessler, Natalie Rosenwasser, Tamar B. Rubinstein, Ekemini A. Ogbu, Emily A. Smitherman, Alaina Miller, Taylor Abounader, Elizabeth Ross, Livie Timmerman, Dhriti Sharma, Jennifer N. Stinson, Stacy Allen, Kabita Nanda, Tala El Tal, Deborah M. Levy, Linda T. Hiraki, Hermine I. Brunner, Mathew Reeves, Steven J. Pierce, Andrea Knight   +29 more
wiley   +1 more source