Results 81 to 90 of about 328,101 (219)

An Injectable Metal‐Drug Supramolecular Condensate Enables Radiosensitization and Systemic Antitumor Immunity for Post‐Surgical Osteosarcoma Therapy

open access: yesAdvanced Science, EarlyView.
This work designed an injectable metal‐drug supramolecular condensate formed from hafnium ions and alendronate (Hf‐ALN) and loaded with the COX‐2 inhibitor celecoxib (CXB) for synergistic radioimmunotherapy of postoperative osteosarcoma. Mechanistically, upon X‐ray irradiation, Hf enhances radiation energy deposition, ROS generation, and DNA damage ...
Tianhua Xiao   +12 more
wiley   +1 more source

Proteogenomic Profiling of Idiopathic Pulmonary Arterial Hypertension Identifies Sex‐Differential Proteins and Candidate Therapeutic Targets

open access: yesAdvanced Science, EarlyView.
An integrated proteogenomic analysis of 44,137 predominantly European‐ancestry UK Biobank participants aged 40–69 years identifies 12 robust proteins associated with idiopathic pulmonary arterial hypertension. These proteins define a high‐mortality molecular endotype, support early detection and mortality prediction, reveal sex‐differential proteomic ...
Xinjie Lin   +18 more
wiley   +1 more source

Acceptance and utilization of web-based self-help for caregivers of children with externalizing disorders

open access: yesChild and Adolescent Psychiatry and Mental Health
Background Web-based self-help interventions for parents of children with ADHD and other externalizing disorders have been proven to be effective. In order to recommend individualized and optimized interventions, a better understanding of the acceptance ...
Laura Wähnke   +6 more
doaj   +1 more source

Parental Rejection, Overprotection and Adolescent Smartphone Addiction: Mediating Role of Sense of Security and Moderating Role of Forgiveness

open access: yesBehavioral Sciences
This study examined a moderated mediation model linking parental rejection and overprotection to smartphone addiction, with sense of security as a mediator and forgiveness as a moderator.
Wuyu Wang   +3 more
doaj   +1 more source

Pilot Trial of Online Measurement Training and Feedback in Family Therapy for Adolescent Behavior Problems. [PDF]

open access: yesJ Clin Child Adolesc Psychol, 2023
Hogue A   +6 more
europepmc   +1 more source

Developmental Environmental Chronotoxicity by Polystyrene Nanoplastics Exacerbates High‐Fat Diet‐Induced Pediatric MAFLD Through Circadian Disruption and Mitochondrial Dysfunction

open access: yesAdvanced Science, EarlyView.
Polystyrene nanoplastics exacerbate high‐fat diet‐induced metabolic dysfunction in an age‐dependent manner. Juvenile mice exhibit greater susceptibility, characterized by circadian disruption, impaired mitochondrial function, reduced energy metabolism, and enhanced hepatic lipid accumulation.
Peihao Xu   +10 more
wiley   +1 more source

The Influence of Explainable Artificial Intelligence and Mental Health Literacy on Professional Psychological Help-Seeking Behavior: The Mediating Role of Psychological Problem Cognition

open access: yesBehavioral Sciences
Approximately 970 million people worldwide suffer from mental disorders, yet over 60% do not seek professional help. Key barriers include low mental health literacy (MHL), insufficient awareness of psychological issues, and the overwhelming and non ...
Weijun Wang   +3 more
doaj   +1 more source

Sluggish Cognitive Tempo among Iranian Children and Adolescents: A Validation Study of the Farsi Child and Adolescent Behavior Inventory (CABI)-Parent Version. [PDF]

open access: yesJ Clin Med, 2022
Sadeghi-Bahmani D   +8 more
europepmc   +1 more source

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