Results 141 to 150 of about 1,362,433 (302)

18β‐Glycyrrhetinic Acid and a Nano‐Liposomal Formulation Alleviate Depression‐Like Behaviors via the Microglial mTOR‐Autophagy‐NLRP3 Axis

Advanced Science, EarlyView.
Using a novel zebrafish‐based inflammatory screening strategy, we screened and identified 18β‐glycyrrhetinic acid (18β‐GA) as a promising anti‐inflammatory candidate. We uncover a microglial mTOR–autophagy–NLRP3 axis that constitutes the mechanistic core of 18β‐GA–mediated neuroprotection.
Hua Gan, Haitao Yuan, Wenjun Zhu, Xiaokang Xie, Shen Zhou, Wenzhi Hao, Xiaowei Mo, Lian Yang, Xiaojuan Li, Junshan Liu, Lijuan Deng, Jiaxu Chen   +11 more
wiley   +1 more source

Transcriptomic and Neuroimaging Decoding of Brain‐Immune Crosstalk in Thyroid Eye Disease

Advanced Science, EarlyView.
This study employed an imaging transcriptomics framework integrating resting‐state fMRI with Allen Human Brain Atlas transcriptomic data, coupled with peripheral blood RNA sequencing, to decode brain‐immune crosstalk in thyroid eye disease. Frontal, parietal, subcortical, and brainstem regions were identified as key neuroimmune‐ vulnerable regions ...
Haiyang Zhang, Yuting Liu, Shufan Jiang, Zilin Fang, Mengda Jiang, Xiaofeng Tao, Tianyi Zhu, Jipeng Li, Sijie Fang, Xuefei Song, Yinwei Li, Jing Sun, Chuanjun Tong, Zhengrun Gao, Huifang Zhou, Xianqun Fan   +15 more
wiley   +1 more source

Endometrial Epithelial Lactate Deficiency Drives CD8+ T‐Cells Dysregulation in Unexplained Recurrent Implantation Failure

Advanced Science, EarlyView.
Unexplained recurrent implantation failure (RIF) represents a significant clinical challenge. Our results demonstrate that reduced lactate production in the RIF endometrium impairs the suppression of cytotoxic CD8+ T‑cells, allowing their proliferation and thereby disrupting the local immune balance essential for successful embryo implantation.
Yuanlin He, Kang Ke, Qingxia Meng, Yichun Guan, Jichun Tan, Hong Lv, Boxian Huang, Chan Tian, Qinyan Zou, Mingxing An, Yao Gao, Jingjing Chen, Xiaoyu Wei, Xi Wang, Hongxia Ma, Yuan Lin, Feiyang Diao, Yayun Gu, Zhibin Hu   +18 more
wiley   +1 more source

Schooling Trajectories and the Development of Brain Dynamics: A Comparative Study of Montessori and Traditional Education

Advanced Science, EarlyView.
We investigate whether Montessori and traditional schooling systems shape the developmental trajectory of large‐scale brain dynamics in different ways. We quantify the arrow of time (“non‐reversibility”) in neural activity during resting state and movie‐watching, revealing distinct maturational patterns.
Elvira del Agua, Anira Escrichs, Yonatan Sanz Perl, Morten L. Kringelbach, Adele Diamond, Solange Denervaud, Gustavo Deco   +6 more
wiley   +1 more source

Reply to the Comments on “GLM7—A Novel Composite Glycolipid Index Derived from Routine Health Indicators for Enhanced Diagnosis and Prediction of Multimorbidity”

Advanced Science, EarlyView.
ABSTRACT This paper is a formal response to the comments raised by Yiquan Wang et al. and Peikai Sun et al. on our published work entitled “GLM7–A Novel Composite Glycolipid Index Derived from Routine Health Indicators for Enhanced Diagnosis and Prediction of Multimorbidity”. We address all the comments in this response.
Zhihua Wang, Suowen Xu
wiley   +1 more source

Ergonomic Sponge Electrodes From Recycled PEDOT:PSS

Advanced Electronic Materials, EarlyView.
ABSTRACT Emerging technologies in human–machine interfacing increasingly aim to develop solutions that naturally conform to the body's unique characteristics. Ergonomics and electrical performance in cutaneous sensing are crucial for accurate and reliable translation of biosignals.
Matías Ceballos, Wei‐Ting Ting, Susanne Thümmler, Esma Ismailova   +3 more
wiley   +1 more source

Enhancing Elderly Health Through Physical Activities: Insights From a Global Bibliometric Review, 1900–2023

AGING MEDICINE, EarlyView.
Bibliometric analysis reveals rising global research on physical activity and elderly health, dominated by developed nations. Key hotspots include healthy aging, physical activity's mental health benefits, and VR exercise interventions. Promoting physical activity is vital for healthy aging, requiring greater technology integration and research from ...
Hongman Wang, Bo Xie, Can Liu, Yifan Song   +3 more
wiley   +1 more source

Clinical Characteristics of Geriatric Asthma in Guangxi of China: A Retrospective Comparative Descriptive Study

AGING MEDICINE, EarlyView.
Geriatric asthmatics exhibit more comorbidities, poorer lung function, higher neutrophil ratios, and elevated CRP levels. ABSTRACT Objective The research analyzed the clinical characteristics of geriatric and nongeriatric asthma cases, aiming to provide new insights into the diagnosis and management of geriatric asthma for clinicians.
Mengxia Gu, Qixiang Sun, Yujia Huang, Yuetian Deng, Xiaohong Jiang   +4 more
wiley   +1 more source

Age and Regional Trends in Groin Hernia Surgery in Japan: An Analysis of Laparoscopic Repair, Outpatient Surgery, and Manual Reduction Using National Database Open Data

Annals of Gastroenterological Surgery, EarlyView.
Using National Database open data from 2014 to 2023, this nationwide study visualizes age‐, sex‐, and region‐specific trends in groin hernia surgery in Japan. Laparoscopic surgery, outpatient surgery, and manual reduction were analyzed to estimate lifetime surgical burden and patterns of emergency‐related healthcare utilization at the population level.
Masanori Sato, Kyosuke Miyazaki, Tatsuya Tazaki, Itsuro Nagae, Taketo Matsubara, Saseem Poudel, Tsuyoshi Takagi, Hidetoshi Wada   +7 more
wiley   +1 more source

Seeing Through the Face: Robust Facial Diagnosis Enhanced by Landmark Detection and Pose Normalization

Advanced Intelligent Systems, EarlyView.
This study proposes a robust, generalizable new approach for facial type diagnosis. Based on landmark detection and pose normalization, a 94.7% diagnostic accuracy is achieved by Combined Heatmap Regression and Coordinate Regression network. This research makes the AI‐generated preliminary diagnosis more interpretable and reducing the impact of ...
Qianyang Xie, Zixian Jiao, Guo Bai, Huimin Zhu, Dahe Zhang, Hui Li, Haixia Lu, Xin Nie, Qing Li, Duohong Zou, Zhiguo Yin, Peilun Li, Chi Yang   +12 more
wiley   +1 more source