Results 91 to 100 of about 3,599,977 (338)

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Adoption Level of Farmers on Maize Cultivation Practices [PDF]

, 2016
The study to measure the extent of adoption level of maize production technologies has been conducted among the maize farmers in the Udumalpet block. The results of the study would help to know the adoption level of farmers which would had in designing ...
Ponnusamy, K.A., Priya, D. Yavana, Venkatapirabu, J.   +2 more
core   +2 more sources

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

Molecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani, Gilgi Friedlander, Gili Perry, Nora Balint‐Lahat, Shlomit Gilad, Dana Morzaev‐Sulzbach, Anjana Shenoy, Noa Bossel Ben‐Moshe, Anya Pavlovsky, Rinat Bernstein‐Molho, Eytan Domany, Iris Barshack, Tamar Geiger, Bella Kaufman, Einav Nili Gal‐Yam   +14 more
wiley   +1 more source

Implementation of Computerized Physician Order Entry in Primary Care: A Scoping Review

Journal of Multidisciplinary Healthcare, 2021
Inge Dhamanti,1– 3 Eva Kurniawati,4 Elida Zairina,5 Ida Nurhaida,6 Salsabila Salsabila1,2 1Faculty of Public Health Universitas Airlangga, Surabaya, East Java, Indonesia; 2Center for Patient Safety Research, Universitas Airlangga, Surabaya, Indonesia ...
Dhamanti I, Kurniawati E, Zairina E, Nurhaida I, Salsabila S   +4 more
doaj  

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

Molecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu, Katherine Eason, Suet‐Feung Chin, Paul A. W. Edwards, Raquel Manzano Garcia, Richard Moulange, Jia Wern Pan, Soo Hwang Teo, Sach Mukherjee, Maurizio Callari, Carlos Caldas, Stephen‐John Sammut, Oscar M. Rueda   +12 more
wiley   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

The Child Adoption Marketplace: Parental Preferences and Adoption Outcomes [PDF]

In the United States child adoption costs vary considerably, ranging from no out-of-pocket expense to $50,000 or more. What are the causes for the variability in adoption expenses?
Gary Anderson, Mark Eiswerth, Mark Skidmore   +2 more
core  

A theory-grounded framework of Open Source Software adoption in SMEs [PDF]

, 2011
This is a post-peer-review, pre-copyedit version of an article published in European Journal of Information Systems. The definitive publisher-authenticated version Macredie, RD and Mijinyawa, K (2011), "A theory-grounded framework of Open Source Software
Agarwal R, Benbasat I, Eisenhardt KM, Fishbein M, Kabiru Mijinyawa, Kwan SK, Lincoln YS, Mayring P, Miles MB, Overby EM, Patton MQ, Robert D Macredie, Rogers EM, Rogers EM, Venkatesh V, Yin RK, Yin RK   +16 more
core   +1 more source

The Supply Chain Has No Clothes: Technology Adoption of Blockchain for Supply Chain Transparency

, 2018
Blockchain technology, popularized by Bitcoin cryptocurrency, is characterized as an open-source, decentralized, distributed database for storing transaction information.
Kristoffer Francisco, David Swanson
semanticscholar   +1 more source

Decrypting cancer's spatial code: from single cells to tissue niches

Molecular Oncology, EarlyView.
Spatial transcriptomics maps gene activity across tissues, offering powerful insights into how cancer cells are organised, switch states and interact with their surroundings. This review outlines emerging computational, artificial intelligence (AI) and geospatial approaches to define cell states, uncover tumour niches and integrate spatial data with ...
Cenk Celik, Shi Pan, Eloise Withnell, Hou Wang Lam, Maria Secrier   +4 more
wiley   +1 more source