Results 91 to 100 of about 678,128 (294)

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Solitary cutaneous mastocytoma in a 3-month-old infant

Iberoamerican Journal of Medicine, 2023
Gonzalo Oliván-Gonzalvo, Ana Cristina Lázaro-Tremul, Javier Ortego-Fernández de Retana, Miguel Ángel Trigo-Cebrián   +3 more
doaj   +1 more source

Local Narratives on the Adoption of Mango Integrated Crop Management Technologies in Samal Island, Philippines

Indonesian Journal of Agricultural Research
The adoption of agricultural technologies is imperative in improving the performance of the local agriculture sector in the Philippines. Numerous technology-based development projects have been implemented across the country.
Nico Jayson Anastacio, Jose V. Camacho, Jr., Aileen V. Lapitan, Ferdinand C. Maquito, Rodmyr F. Datoon, Irene R. Tanzo, Jeanarah M. Gapas   +6 more
doaj   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

DASP: A Framework for Driving the Adoption of Software Security Practices [PDF]

, 2022
Enrique Larios-Vargas, Omar Elazhary, Soroush Yousefi, Derek Lowlind, Michael Vliek, Margaret‐Anne Storey   +5 more
openalex   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

L’impact de l’adoption du programme de fidélisation sur l’apparition d’un comportement de fidélité:Importance des bénéfices perçus

Revue Marocaine de Recherche en Management et Marketing, 2012
Notre recherche propose un modèle au sein duquel sont examinés d’une part, la manière dont les bénéfices perçus affectent l’adoption d’un programme de fidélisation et d’autre part, l’impact de la durée d’adoption du programme de ...
Jihène BEN ROMDHANE, M. Mustapha ZGHAL
doaj  

A avaliação psicossocial no contexto da adoção: vivências das famílias adotantes

Psicologia: Teoria e Pesquisa
Foi realizada uma pesquisa de enfoque qualitativo com duas famílias adotantes, através de entrevista de grupo focal em um serviço de adoção de uma Vara da Infância e da Juventude.
Liana Fortunato Costa, Niva Maria Vasques Campos   +1 more
doaj   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source