Results 81 to 90 of about 599,165 (266)

Forecasting the Dialysis Burden in Japan: Validation‐Based Projections of Prevalence and Incidence Through 2050

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Japan has one of the highest dialysis prevalence rates worldwide and a shrinking, aging population. Whether dialysis burden has entered a sustained post‐peak phase or whether recent declines partly reflect pandemic‐related disruptions remains uncertain.
Hatice Şahin, Berrak Itır Aylı, Nüket Paksoy   +2 more
wiley   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Adoption of a child by homosexuals in light of the best interests of the child principle in accordance with its understanding in Polish family law – subjective interpretation of the author

Horyzonty Wychowania, 2017
RESEARCH OBJECTIVE: The purpose of this article is to present arguments against the possibility of adoption of a child by a homosexual person in the light of Polish family law.
Marta Prucnal-Wójcik
doaj  

Local Narratives on the Adoption of Mango Integrated Crop Management Technologies in Samal Island, Philippines

Indonesian Journal of Agricultural Research
The adoption of agricultural technologies is imperative in improving the performance of the local agriculture sector in the Philippines. Numerous technology-based development projects have been implemented across the country.
Nico Jayson Anastacio, Jose V. Camacho, Jr., Aileen V. Lapitan, Ferdinand C. Maquito, Rodmyr F. Datoon, Irene R. Tanzo, Jeanarah M. Gapas   +6 more
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Solitary cutaneous mastocytoma in a 3-month-old infant

Iberoamerican Journal of Medicine, 2023
Gonzalo Oliván-Gonzalvo, Ana Cristina Lázaro-Tremul, Javier Ortego-Fernández de Retana, Miguel Ángel Trigo-Cebrián   +3 more
doaj   +1 more source

A avaliação psicossocial no contexto da adoção: vivências das famílias adotantes

Psicologia: Teoria e Pesquisa
Foi realizada uma pesquisa de enfoque qualitativo com duas famílias adotantes, através de entrevista de grupo focal em um serviço de adoção de uma Vara da Infância e da Juventude.
Liana Fortunato Costa, Niva Maria Vasques Campos   +1 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source