Results 91 to 100 of about 592,910 (266)

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Adoption of a child by homosexuals in light of the best interests of the child principle in accordance with its understanding in Polish family law – subjective interpretation of the author

Horyzonty Wychowania, 2017
RESEARCH OBJECTIVE: The purpose of this article is to present arguments against the possibility of adoption of a child by a homosexual person in the light of Polish family law.
Marta Prucnal-Wójcik
doaj  

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Local Narratives on the Adoption of Mango Integrated Crop Management Technologies in Samal Island, Philippines

Indonesian Journal of Agricultural Research
The adoption of agricultural technologies is imperative in improving the performance of the local agriculture sector in the Philippines. Numerous technology-based development projects have been implemented across the country.
Nico Jayson Anastacio, Jose V. Camacho, Jr., Aileen V. Lapitan, Ferdinand C. Maquito, Rodmyr F. Datoon, Irene R. Tanzo, Jeanarah M. Gapas   +6 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Solitary cutaneous mastocytoma in a 3-month-old infant

Iberoamerican Journal of Medicine, 2023
Gonzalo Oliván-Gonzalvo, Ana Cristina Lázaro-Tremul, Javier Ortego-Fernández de Retana, Miguel Ángel Trigo-Cebrián   +3 more
doaj   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

A avaliação psicossocial no contexto da adoção: vivências das famílias adotantes

Psicologia: Teoria e Pesquisa
Foi realizada uma pesquisa de enfoque qualitativo com duas famílias adotantes, através de entrevista de grupo focal em um serviço de adoção de uma Vara da Infância e da Juventude.
Liana Fortunato Costa, Niva Maria Vasques Campos   +1 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

L’impact de l’adoption du programme de fidélisation sur l’apparition d’un comportement de fidélité:Importance des bénéfices perçus

Revue Marocaine de Recherche en Management et Marketing, 2012
Notre recherche propose un modèle au sein duquel sont examinés d’une part, la manière dont les bénéfices perçus affectent l’adoption d’un programme de fidélisation et d’autre part, l’impact de la durée d’adoption du programme de ...
Jihène BEN ROMDHANE, M. Mustapha ZGHAL
doaj