Results 41 to 50 of about 49,600 (261)

Diffusion mechanism of green building in industrial clusters: An agent-based modeling approach

Developments in the Built Environment
Industrial clusters are conducive to accelerating the adoption of green technologies and green buildings, but the underlying mechanism of cluster-based adoption among different stakeholders is seldom examined.
Mi Pan, Xiaojing Zhao, Zhaotong Li
doaj   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Diffusion of Innovations and Adoption of Transradial Intervention [PDF]

Circulation: Cardiovascular Interventions, 2013
Adoption of scientific innovations, including drugs, devices, and techniques, is critical to the advancement of safe and efficacious healthcare. Often, however, disconnects between scientific evidence and clinical practice are observed with less supported innovations being widely adopted and those with stronger data underused.
openaire   +2 more sources

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Harnessing indigenous social institutions for technology adoption: ‘Afoosha’ society of Ethiopia

Development Studies Research, 2019
The search for effective mechanisms in technology adoption is high on the agenda of researchers and policy makers. In Ethiopia, adoption of technologies followed the diffusion of innovation information through public extension agents, cooperatives and ...
Desalegn Yadeta Wedajo, Temesgen Keno Belissa, Mideksa Fufa Jilito   +2 more
doaj   +1 more source

A System Dynamics Model for the Diffusion of Cloud Manufacturing Mode With Evolutionary Game Theory

IEEE Access, 2021
Cloud manufacturing (CMfg) is emerging as an advanced green and efficient manufacturing mode for the manufacturing industry. It has gained extensive attentions owing to the unique manufacturing mode and advantages.
Tianri Wang, Chao Li, Pengzhi Zhang
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Expanding Downward: Innovation, Diffusion, and State Policy Adoptions of Universal Preschool

Education Policy Analysis Archives, 2015
Framed within the theoretical framework of policy innovation and diffusion, this study explores both interstate (diffusion) and intrastate predictors of adoption of state universal preschool policies.
F. Chris Curran
doaj   +1 more source