Results 41 to 50 of about 60,334 (303)

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Integrating the TOE framework and DOI theory to dissect and understand the key elements of AI adoption in sociotechnical systems

South African Computer Journal
This study is interested in increasing the likelihood of achieving the organisational adoption of artificial intelligence that has a positive  outcome.
Danie Smit, Sunet Eybers, Alta van der Merwe, Rene Wies, Nica Human, Julia Pielmeier   +5 more
doaj   +1 more source

Understanding the adoption of Pay-for-performance in state governments: A diffusion theory approach

Transylvanian Review of Administrative Sciences, 2018
As various private sector practices have been introduced into the public sector, some were adopted without careful assessment of potential policy and management implications. One such example is the adoption of pay-for-performance (PFP).
Sangyub RYU, John C. RONQUILLO, Seejeen PARK   +2 more
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Modifying the Bass diffusion model to study adoption of radical new foods-The case of edible insects in the Netherlands.

PLoS ONE, 2020
Developing new food products is a complex process. Even if a company performs new product development activities successfully, it is still uncertain if consumers will adopt the product.
Andrijana Horvat, Vincenzo Fogliano, Pieternel A Luning   +2 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

CONCEPTUAL MODELS, BARRIERS AND OPPORTUNITIES FOR ADOPTION AND DIFFUSION OF AGRICULTURAL INNOVATIONS [PDF]

Scientific Papers Series : Management, Economic Engineering in Agriculture and Rural Development, 2023
Agricultural innovations are considered a key driver in overcoming the global challenges related to climate change, natural resources scarcity and food security. However, the features of agriculture increase the degree of complexity in the implementation
Dobri DUNCHEV, Rositsa BELUHOVA-UZUNOVA
doaj  

Researchers’ Adoption of an Institutional Central Fund for Open-Access Article-Processing Charges [PDF]

Sage Open, 2016
This article analyzes researchers’ adoption of an institutional central fund (or faculty publication fund) for open-access (OA) article-processing charges (APCs) to contribute to a wider understanding of take-up of OA journal publishing (“Gold” OA). Quantitative data, recording central fund usage at the University of Nottingham from 2006 to 2014, are ...
Pinfield, S., Middleton, C.
openaire   +3 more sources

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Smart-Tag Your Cows: A Lesson Learned from SIMAPI Adoption In A Farming Village In Central Java Indonesia [PDF]

Journal of Global Innovations in Agricultural Sciences
The widespread use of the internet has accelerated digital technology adoption in almost all aspects of life in Indonesia, including the country’s small-scale livestock industry.
Nora N. Amal, Subejo Subejo
doaj   +1 more source