Results 61 to 70 of about 72,700 (276)

Dynamic Analysis and Optimal Control of a Multi-stage Innovation Diffusion Model Incorporating Time Delay in Awareness and Adoption Process [PDF]

International Journal of Mathematical, Engineering and Management Sciences
This research presents a new multi-stage innovation diffusion model that incorporates the delay effect due to the complexity and variability of actual diffusion processes as an evaluation time delay parameter, efficiently using the mathematical framework
Onamy Ramdinpuii, Sumit Kaur Bhatia, Shivani Bali, Kuldeep Chaudhary   +3 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

The socio-technical adoption and diffusion of digital health innovations: The development of the STAD-HC model based on telemedicine in Germany

Digital Business
Digital and telemedicine innovations are increasingly central to healthcare transformation, yet their adoption and diffusion remain complex. While the Diffusion of Innovations (DOI) theory explains staged adoption processes, it underrepresents socio ...
Yvonne Rauner, Harald Stummer
doaj   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Adoption and diffusion of Frontier technologies: Tracing global collaborative research networks on ChatGPT

Journal of Information Science
The successful adoption of Fourth Industrial Revolution (4IR) frontier technologies is crucial for corporate and national sustainability, with knowledge transfer playing a key role in this process. Indeed, past research has demonstrated that global collaboration networks can generate innovative ideas and customised solutions to key development ...
Richard Ramsawak, Greeni Maheshwari, Mehrdad Maghsoudi, Mehrdad Agha Mohammad Ali Kermani, Tung Bui Duy   +4 more
openaire   +1 more source

Mapping factors influencing EAI adoption in the local government authorities on different phases of the adoption lifecycle [PDF]

, 2008
Several private and public organisations have adopted Enterprise Application Integration (EAI), however, its application in the Local Government Authorities (LGAs) is limited.
Kamal, M, Themistocleous, M, Elliman, T
core  

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Contextualizing the Framing Effects of Policy Adoption: Interstate Competition and Autonomous Vehicle Discourse in the U.S.

Social Sciences
Why do certain frames gain prominence while others become marginalized in public discourse about emerging technologies? Existing research shows that policy adoption serves as a powerful discursive signal that shapes how issues are interpreted.
Sang-Teck Oh
doaj   +1 more source