Results 91 to 100 of about 94,528 (347)

Impact of pre‐therapy glioblastoma multiforme microenvironment on clinical response to autologous CMV‐specific T‐cell therapy

Clinical & Translational Immunology, 2019
Objectives Clinical response to antibody‐based immunotherapies targeting checkpoint inhibitors is critically dependent on the tumor immune microenvironment (TIME).
David G Walker, Reshma Shakya, Beth Morrison, Michelle A Neller, Katherine K Matthews, John Nicholls, Corey Smith, Rajiv Khanna   +7 more
doaj   +1 more source

Adoptive tumor infiltrating lymphocytes cell therapy for cervical cancer

Human Vaccines & Immunotherapeutics, 2022
Cervical cancer is one of the most common malignancies among females. As a virus-related cancer, cervical cancer has attracted a lot of attention to develop virus-targeted immune therapy, including vaccine and adoptive immune cell therapy (ACT). Adoptive
Yahui Zhu, Jing Zhou, Lijing Zhu, Wenjing Hu, Baorui Liu, Li Xie   +5 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Adoptive T Cell Therapy Following Haploidentical Hematopoietic Stem Cell Transplantation

Frontiers in Immunology, 2019
Delayed immune reconstitution and the consequently high rates of leukemia relapse and infectious complications are the main limitations of haploidentical hematopoietic stem cell transplantation.
Ping Zhang, Siok-Keen Tey, Siok-Keen Tey, Siok-Keen Tey   +3 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Homing to solid cancers: a vascular checkpoint in adoptive cell therapy using CAR T-cells [PDF]

, 2016
The success of adoptive T-cell therapies for the treatment of cancer patients depends on transferred T-lymphocytes finding and infiltrating cancerous tissues.
Ager, Elizabeth, Mohammed, Rebar N., Watson, Heulwen Angharad, Wehenkel, Sophie C.   +3 more
core   +2 more sources

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Adoptive transfer of natural killer cells in therapeutic treatment of COVID-19 patients

Egyptian Journal of Medical Human Genetics
Background Natural killer (NK) cells are crucial constituents of innate immunity, playing a vital role in the early defense against viral infections and cancer.
Abdulaziz Alamri
doaj   +1 more source

To Remember or to Forget: The Role of Good and Bad Memories in Adoptive T Cell Therapy for Tumors

Frontiers in Immunology, 2020
The generation of immunological memory is a hallmark of adaptive immunity by which the immune system “remembers” a previous encounter with an antigen expressed by pathogens, tumors, or normal tissues; and, upon secondary encounters, mounts faster and ...
Anna Mondino, Teresa Manzo
doaj   +1 more source

Engineering Strategies to Enhance TCR-Based Adoptive T Cell Therapy [PDF]

, 2020
Jan A. Rath, Caroline Arber
openalex   +1 more source