Results 251 to 260 of about 742,426 (338)
Advanced Science, Volume 13, Issue 4, 19 January 2026.This study examines major depressive disorder with atypical features and psychotic symptoms through a multi‐omics precision medicine approach. By integrating clinical assessments, WBC scRNA‐seq, plasma proteomics, and brain organoid models, it uncovers immune dysregulation, synaptic protein alterations, and stress‐sensitive neuronal changes.
Insook Ahn +5 more
wiley +1 more source
Advanced Science, Volume 13, Issue 1, 5 January 2026.We developed a smart MRI nanoprobe targeting BACE1 and Aβ plaques. It crosses the blood‐brain barrier. Upon encountering BACE1, the probe is cleaved, enabling T1WI imaging detection. Subsequent reaction with ONOO− induces probe aggregation, enhancing magnetic susceptibility for sensitive SWI imaging of Aβ plaques.
Minghua Li +13 more
wiley +1 more source
Alzheimer's &Dementia, Volume 22, Issue 1, January 2026.Abstract Alzheimer's disease (AD) is projected to become the highest‐burden neurological disorder globally. Mounting evidence implicates the gut microbiome in AD pathogenesis. This scoping review of gut microbiomes in mild cognitive impairment (MCI) and AD included dietary and probiotic interventions.
Alison Warren +10 more
wiley +1 more source
Brain and Behavior, Volume 16, Issue 1, January 2026.Salivary gland uptake on 18F‐florbetaben PET was not associated with cortical amyloid burden in patients across the cognitive spectrum. No significant differences in salivary gland amyloid‐PET uptake were observed according to dementia severity or clinical diagnosis.
Hyun Woo Kwon +4 more
wiley +1 more source
Brain and Behavior, Volume 16, Issue 1, January 2026.Arterial stiffness and depressive symptoms independently and jointly increased the risk of new‐onset Chronic Obstructive Pulmonary Disease (COPD) in older Chinese adults. Their small bidirectional mediation effects suggest interconnected vascular and psychological pathways contributing to COPD development.
Qinqin Shen +5 more
wiley +1 more source