Results 21 to 30 of about 79,543 (252)

The effects of acute heat stress on proliferative and apoptotic processes in the rat adrenal cortex [PDF]

Archives of Biological Sciences, 2013
Hyperthermia can cause significant structural and functional reorganization of tissues and organs. The proliferative and apoptotic processes of rat adrenal cortex were analyzed by light and electron microscopy after an acute exposure to high ambient ...
Petrović-Kosanović Dragana, Ajdžanović V., Čakić-Milošević Maja, Koko Vesna, Milošević Verica   +4 more
doaj   +1 more source

The Interplay between Estrogen and Fetal Adrenal Cortex

Journal of Nutrition and Metabolism, 2012
Estrogen is a steroid hormone that regulates embryogenesis, cell proliferation and differentiation, organogenesis, the timing of parturition, and fetal imprinting by carrying chemical messages from glands to cells within tissues or organs in the body ...
Jovana Kaludjerovic, Wendy E. Ward
doaj   +1 more source

Pediatric Adrenal Insufficiency: Diagnosis, Management, and New Therapies

International Journal of Pediatrics, 2018
Adrenal insufficiency may result from a wide variety of congenital or acquired disorders of hypothalamus, pituitary, or adrenal cortex. Destruction or dysfunction of the adrenal cortex is the cause of primary adrenal insufficiency, while secondary ...
Sasigarn A. Bowden, Rohan Henry
doaj   +1 more source

Laparoscopic cortical-sparing adrenal surgery in pheochromocytomas associated with hereditary neoplasia syndromes

Endokrynologia Polska, 2020
INTRODUCTION: Pheochromocytomas in hereditary syndromes tend to grow multifocal with adrenal involvement on both sides. Surgical treatment with bilateral adrenalectomy inevitably leads to life-long hormonal dependence, which significantly affects quality
Kornelia Hasse-Lazar, Marcin Zeman, Agnieszka Kotecka-Blicharz, Marta Legutko, Agnieszka Czarniecka, Barbara Michalik, Aleksandra Król, Piotr Szymański, Agnieszka Pawlaczek, Małgorzata Oczko-Wojciechowska, Maciej Grajek, Tomasz Gawlik, Daria Handkiewicz-Junak, Barbara Jarząb   +13 more
doaj   +1 more source

Single-cell and spatial transcriptomics analysis of human adrenal aging

Molecular Metabolism
Objective: The human adrenal cortex comprises three functionally and structurally distinct layers that produce layer-specific steroid hormones. With aging, the human adrenal cortex undergoes functional and structural alteration or “adrenal aging ...
Norifusa Iwahashi, Hironobu Umakoshi, Masamichi Fujita, Tazuru Fukumoto, Tatsuki Ogasawara, Maki Yokomoto-Umakoshi, Hiroki Kaneko, Hiroshi Nakao, Namiko Kawamura, Naohiro Uchida, Yayoi Matsuda, Ryuichi Sakamoto, Masahide Seki, Yutaka Suzuki, Kohta Nakatani, Yoshihiro Izumi, Takeshi Bamba, Yoshinao Oda, Yoshihiro Ogawa   +18 more
doaj   +1 more source

Integrated Transcriptomics Reveals Evolutionary Trajectories and Cell Density‐Dependent Mechanisms in Aldosterone‐Producing Adenomas

Advanced Science, EarlyView.
Aldosterone‐producing adenomas (APAs) develop via two distinct paths: directly from adrenal zona glomerulosa (zG) cells, or stepwise from zG cells through aldosterone‐producing micronodules (APMs) before progressing to APAs. Advanced single‐cell and spatial analyses identified distinct cell states linked to oxidative stress and cell–cell interactions ...
Zhuolun Sun, Changying Jing, Martina Tetti, Siyuan Gong, Jia Wei, Yingxian Pang, Martin Reincke, Tracy Ann Williams   +7 more
wiley   +1 more source

Measurement of the adrenal cortex reserve using depot beta 1-24-corticotrophin. II---in thyroid diseases.

Acta Médica Portuguesa, 1979
Mean plasma cortisol 4 to 6 hours after 1 mg Synacthen Depot in normal subjects, simple goiter and hypothyroidism were not significantly different. On the contrary after stimulation cortisol levels in untreated hyperthyroidism were significantly below ...
A. Galvão-Teles
doaj   +1 more source

4‐Hydroxybenzyl Alcohol Mitigates Hyperlipidemia‐Associated Depression by Inhibiting Neuroinflammation via the NKIRAS2/NF‐κB Pathway

Advanced Science, EarlyView.
4‐HBA upregulates NKIRAS2 levels, inhibiting the activation of the NF‐κB pathway and subsequently reducing the levels of neuroinflammatory markers. This modulation helps restore normal mood and behavior in hyperlipidemic conditions, providing a potential therapeutic strategy for managing hyperlipidemia‐associated depression.
Ying Zhang, Meng Teng, Wenxuan He, Lanzhou Li, Yongfeng Zhang, Shimiao Wang, Chunyue Wang, Di Wang   +7 more
wiley   +1 more source

Unveiling a New Link: Cholesterol Deficiency in Smith–Lemli–Opitz and Niemann–Pick C as a Driver of Ciliopathies

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT The ciliopathies are a group of genetic disorders caused by defective function of either the primary cilia (a large number) or the motile cilia (a much smaller number). These have been defined as diseases with mutations in genes encoding individual ciliary or cilia‐associated proteins.
Robert P. Erickson, Maria Teresa Fiorenza   +1 more
wiley   +1 more source

Evaluating the role of aldosterone synthesis on adrenal cell fate

Frontiers in Endocrinology
Hypertension affects one-third of the adult population worldwide, with primary aldosteronism (PA) accounting for at least 5-10% of these cases. The aldosterone synthase enzyme (CYP11B2) plays a pivotal role in PA manifestation, as increased expression of
Amnani Aminuddin, Morris J. Brown, Morris J. Brown, Elena Aisha Azizan, Elena Aisha Azizan, Elena Aisha Azizan   +5 more
doaj   +1 more source