Results 231 to 240 of about 34,980 (272)

GWAS Identifies SNPs Associated With Severe Adverse Events and Efficacy in Advanced Renal Cell Carcinoma Treated With Nivolumab

Cancer Science, EarlyView.
This study highlights the importance of germline genetic markers in predicting severe trAEs caused by nivolumab. Our findings support their potential to guide personalized immunotherapy and improve treatment safety and efficacy in advanced ccRCC and other cancers.
Tokiyoshi Tanegashima, Masaki Shiota, Shusuke Akamatsu, Hideaki Miyake, Masayuki Takahashi, Mototsugu Oya, Norihiko Tsuchiya, Naoya Masumori, Hideyasu Matsuyama, Wataru Obara, Nobuo Shinohara, Kiyohide Fujimoto, Masahiro Nozawa, Kojiro Ohba, Chikara Ohyama, Katsuyoshi Hashine, Tomomi Kamba, Koji Mita, Momokazu Gotoh, Shuichi Tatarano, Masato Fujisawa, Yoshihiko Tomita, Shoichiro Mukai, Keiichi Ito, Shoji Tokunaga, Masatoshi Eto, SNiP‐RCC investigators   +26 more
wiley   +1 more source

Secondary Adrenal Insufficiency Misdiagnosed as a Psychiatric Illness, Presenting in Addisonian Crisis: Case Report

Rashmi Shukla, Isha Prakash, Avneendra Kumar Singh, Adarsh Tripathi, Nalin Shukla   +4 more
openalex   +1 more source

Adrenal Insufficiency During Treatment With Immune‐Checkpoint Inhibitors: How to Simplify the Diagnostic Pathway?

Clinical Endocrinology, EarlyView.
ABSTRACT Objective and Background Early identification of adrenal insufficiency (AI) during immune‐checkpoint inhibitors (ICIs) is crucial to prevent life‐threatening consequences; however, the diagnosis is challenging. Design, Patients and Measurement In this prospective observational study, ICI‐treated cancer patients with morning serum cortisol (SC)
Alice Nervo, Giovanni Gruosso, Marta Marino, Enrica Migliore, Matteo Rubiolo, Elisa Vaccaro, Emanuela Arvat   +6 more
wiley   +1 more source

Management of adrenal insufficiency risk after long-term systemic glucocorticoid therapy in Duchenne muscular dystrophy: Clinical practice recommendations [PDF]

, 2019
Bowden, Sasigarn A, Connolly, Anne M, Kinnett, Kathi, Zeitler, Philip S   +3 more
core   +1 more source

Mass Spectrometric Measurements of 11‐Deoxycortisol, Androstenedione and Dehydroepiandrosterone Are Superior to Cortisol to Assess Selectivity of Non‐Stimulated Adrenal Vein Sampling

Clinical Endocrinology, EarlyView.
ABSTRACT Objective Successful adrenal venous sampling (AVS) is traditionally assessed using the ratio of cortisol in adrenal to peripheral venous plasma to calculate the selectivity index. With mass spectrometry other steroids can be simultaneously measured that may improve numbers of apparent successful sampling procedures.
Francesco Alessi, Christina Pamporaki, Mirko Peitzsch, Georgiana Constantinescu, Hanna Remde, Lydia Kürzinger, Carmina T. Fuss, Manuel Schulze, Sybille Fuld, Sradha Kotwal, Jun Yang, Martin Reincke, Felix Beuschlein, Jacques W. M. Lenders, Graeme Eisenhofer   +14 more
wiley   +1 more source

Adrenal Insufficiency in Children With Nephrotic Syndrome Treated With High Doses of Glucocorticoids

Acta Paediatrica, EarlyView.
Claudia Mau Kai, Hanne Nørgaard, Line Thousig Sehested, Katharina M. Main, Ida Maria Schmidt   +4 more
wiley   +1 more source

Mixed Gonadal Dysgenesis: A Comprehensive Review of Clinical Spectrum, Diagnostic Strategies, and Management Approaches

Clinical Endocrinology, EarlyView.
ABSTRACT Background Mixed gonadal dysgenesis (MGD) is a rare form of differences in sex development (DSD) typically associated with 45,X/46,XY mosaicism. The phenotypic presentation of MGD varies from atypical genitalia to typical male or female appearances often associated with Turner stigmata.
Dinesh Giri, Sushil Yewale, Hannah Hickingbotham, Cara Williams, Mohamed Shalaby, Julie Alderson, Julie Park   +6 more
wiley   +1 more source

Efficacy and Tolerability of Metyrapone in Mild Autonomous Cortisol Secretion: Real‐World Findings From Clinical Practice

Clinical Endocrinology, EarlyView.
ABSTRACT Objective Mild autonomous cortisol secretion (MACS) is associated with increased cardiometabolic risk factors including hypertension, type 2 diabetes and dyslipidaemia. By using evening doses of metyrapone, a short‐acting 11‐β hydroxylase inhibitor, it has been shown that it is possible to reset the abnormal circadian cortisol rhythm in MACS ...
Simon Berry, Ahmed Iqbal, John Newell‐Price, Miguel Debono   +3 more
wiley   +1 more source

PRIMARY BILATERAL ADRENAL LYMPHOMA PRESENTING WITH IMPENDING ADRENAL CRISIS. [PDF]

Acta Endocrinol (Buchar)
Grigorie D, Sucaliuc A, Ranetti A, Dobrea C, Bancos I.   +4 more
europepmc   +1 more source

Unraveling the Role of WDR91: Case Report of a Previously Unrecognized Clinical Entity

Clinical Genetics, EarlyView.
A novel case is herein described to expand the genetic and clinical spectrum of WDR91 and characterize a previously unrecognized autosomal recessive neurodevelopmental disorder. WDR91 deficiency results in neuronal loss, cortical thinning, and impaired brain development.
Nikolaos M. Marinakis, Afrodite Kampouraki, Danai Veltra, Faidon‐Nikolaos Tilemis, Maria Vasilopoulou, Aikaterini Dokou, Elissavet Georgiadou, Euthalia Karavergou, Maria Christolouka, Alexis Alexopoulos, Dimitra Kirillidi, Maria Goudesidou, Konstantina Kosma, Christalena Sofocleous, Periklis Makrythanasis   +14 more
wiley   +1 more source