Transcriptome modulation by hydrocortisone in severe burn shock: ancillary analysis of a prospective randomized trial [PDF]
Critical Care, 2017 Background Despite shortening vasopressor use in shock, hydrocortisone administration remains controversial, with potential harm to the immune system. Few studies have assessed the impact of hydrocortisone on the transcriptional response in shock, and we
Jonathan Plassais +7 more
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Endocrine Connections, 2017 Introduction: Patients who need glucocorticoid replacement in both primary and secondary adrenal insufficiency (AI) have the choice of either once-daily prednisolone or thrice-daily hydrocortisone.
David J F Smith +3 more
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Hydrocortisone versus dexamethasone in cerebral salt-wasting after aneurysmal subarachnoid hemorrhage [PDF]
Brain and SpineIntroduction: Cerebral salt wasting syndrome (CSW) is frequently observed in aneurysmal subarachnoid hemorrhage (SAH) patients and results in excessive natriuresis with decreased extracellular fluids, leading to hyponatremia and hypovolemia. Hyponatremia
Leander Steger +7 more
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Effect of Prophylaxis for Early Adrenal Insufficiency Using Low-Dose Hydrocortisone in Very Preterm Infants: An Individual Patient Data Meta-Analysis [PDF]
Jornal de Pediatria, 2018 OBJECTIVE To assess the effect of prophylaxis for early adrenal insufficiency using low-dose hydrocortisone on survival without bronchopulmonary dysplasia (BPD) in very preterm infants using an individual patient data meta-analysis.
Michele L. Shaffer +5 more
openalex +2 more sources
Pitfalls in the management of undiagnosed secondary adrenal insufficiency: a case report and review of the literature [PDF]
Journal of Medical Case ReportsBackground Prolonged cortisol deficiency in undiagnosed central adrenal insufficiency can lead to severe hypotonic hyponatremia due to inappropriate vasopressin secretion and malnutrition caused by inhibition of orexigenic signals.
Koharu Sakai +4 more
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Determination of hydrocortisone and cortisone in artificial saliva by spray assisted fine droplet formation liquid phase microextraction coupled to LC–MS/MS [PDF]
Scientific ReportsHydrocortisone and cortisone are clinically informative steroids whose joint measurement at low concentrations is essential for ratio-reliable interpretation.
Selim Gürsoy +3 more
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Content uniformity of quartered hydrocortisone tablets in comparison with mini-tablets for paediatric dosing [PDF]
BMJ Paediatrics Open, 2018 Objectives Children requiring cortisol replacement therapy are often prescribed hydrocortisone doses of 2.5 mg, but as this is commercially unavailable 10 mg tablets, with functional break lines, are split commonly in an attempt to deliver the correct ...
Blair, J +5 more
core +2 more sources
Research progress on therapeutic effect and mechanism of hydrocortisone on sepsis [PDF]
Cellular, Molecular and Biomedical Reports, 2023 Sepsis has remained a high mortality rate worldwide. Endothelial cell dysfunction is closely associated with the development of sepsis. Hydrocortisone has potent immunological and antitoxic effects, and thus it is frequently used in the treatment of ...
Yicen Long +4 more
doaj +1 more source
Frontiers in Veterinary Science, 2022 ObjectivesTo determine whether administration of intravenous hydrocortisone is a safe and effective alternative treatment in comparison to the traditional treatment with prednisolone/dexamethasone in dogs presenting with Addisonian crisis; and to assess ...
Athanasia Mitropoulou +3 more
doaj +1 more source
Stability of Hydrocortisone in Oral Powder Form Compounded for Pediatric Patients in Japan
Pharmaceutics, 2021 Hydrocortisone has been utilized in the management of adrenal insufficiency. For pediatric patients, the commercially available enteral form of hydrocortisone tablets (Cortoril®) is administered in powder form after being compounded by a pharmacist ...
Jumpei Saito +8 more
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