Results 1 to 10 of about 103,469 (251)

Steroid administration, timing, and dose in patients with septic shock in the emergency department: retrospective analysis of a multicenter prospective cohort study [PDF]

Scientific Reports
The benefit and optimal timing of corticosteroids in septic shock remain debated. Most evidence comes from intensive care unit-based studies, although key treatment decisions are often made early in the emergency department (ED). This study evaluated the
Sejoong Ahn, Chiwon Ahn, Sung Yeon Hwang, Sang-Min Kim, Jong-Hak Park, Won Young Kim, Sung-Joon Park, Sung-Hyuk Choi, Woon Yong Kwon, Taeyoung Kong, Sung Phil Chung, Byuk Sung Ko, Tae Ho Lim, Tae Gun Shin, Kyuseok Kim, the Korean Shock Society   +15 more
doaj   +2 more sources

Association between hydrocortisone use and outcomes in sepsis patients with hospital-acquired bloodstream infections: An ancillary analysis of the EUROBACT-2 cohort. [PDF]

PLoS ONE
PurposeCorticosteroids are suggested for selected patients with septic shock, but their association with outcomes has not been specifically investigated in patients with hospital-acquired bloodstream infections (HA-BSI).
Gary Duclos, Mohamed Boucekine, Alexis Tabah, Stéphane Ruckly, Niccolò Buetti, Jean François Timsit, Marc Leone, EUROBACT-2 Study Group, ESICM, ESCMID ESGCIP, OUTCOMEREA Network   +10 more
doaj   +2 more sources

Hydrocortisone for prevention or treatment of bronchopulmonary dysplasia: long-term neurodevelopmental safety and efficacy—a meta-analysis of randomized clinical trials [PDF]

Frontiers in Pediatrics
BackgroundPostnatal systemic steroids can reduce inflammation that contributes to bronchopulmonary dysplasia (BPD) in extremely preterm infants; however, prior experience with dexamethasone raised concerns regarding long-term neurodevelopmental harm.
Kawthar Ahmed Shehab, Rahaf Muslih N. Almatrafi, Ethar Ali, Yara Albargi, Sama Saabi, Halah Alhassan Aljohani, Rayan Nabil Almuhanna, Raghad Alnaami, Khalid Abdulrahman Almehery, Reema Safar Alamri, Sarah Ahmed A. Baqer, Shouq Naif Aloufi, Ahmed Elaraby, Bedah Mohammed Alnawfal   +13 more
doaj   +2 more sources

Research progress on therapeutic effect and mechanism of hydrocortisone on sepsis [PDF]

Cellular, Molecular and Biomedical Reports, 2023
Sepsis has remained a high mortality rate worldwide. Endothelial cell dysfunction is closely associated with the development of sepsis. Hydrocortisone has potent immunological and antitoxic effects, and thus it is frequently used in the treatment of ...
Yicen Long, Xiaoqiang Du, Zhi Ouyang, Jian Zhong, Ye Zeng   +4 more
doaj   +1 more source

Comparison of Hydrocortisone Continuous Rate Infusion and Prednisolone or Dexamethasone Administration for Treatment of Acute Hypoadrenocortical (Addisonian) Crisis in Dogs

Frontiers in Veterinary Science, 2022
ObjectivesTo determine whether administration of intravenous hydrocortisone is a safe and effective alternative treatment in comparison to the traditional treatment with prednisolone/dexamethasone in dogs presenting with Addisonian crisis; and to assess ...
Athanasia Mitropoulou, Mia-Katharina Häuser, Hendrik Lehmann, Katarina Hazuchova   +3 more
doaj   +1 more source

Stability of Hydrocortisone in Oral Powder Form Compounded for Pediatric Patients in Japan

Pharmaceutics, 2021
Hydrocortisone has been utilized in the management of adrenal insufficiency. For pediatric patients, the commercially available enteral form of hydrocortisone tablets (Cortoril®) is administered in powder form after being compounded by a pharmacist ...
Jumpei Saito, Nozomi Yoshikawa, Takehisa Hanawa, Ayuna Ozawa, Takahiro Matsumoto, Tsutomu Harada, Kana Iwahashi, Hidefumi Nakamura, Akimasa Yamatani   +8 more
doaj   +1 more source

Post‐Cardiac Arrest Hydrocortisone Use Ameliorates Cardiac Mitochondrial Injury in a Male Rat Model of Ventricular Fibrillation Cardiac Arrest

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021
Background Steroid use after cardiac arrest has been reported to improve survival and neurological outcome in cardiac arrest survivors. The study aimed to evaluate the effect of post‐arrest hydrocortisone use on myocardial damage and cardiac ...
Min‐Shan Tsai, Chien‐Hua Huang, Chen‐Hsu Wang, Hsaio‐Ju Cheng, Shih‐Ni Wu, Wei‐Tien Chang, Wen‐Jone Chen   +6 more
doaj   +1 more source

Thiram, an inhibitor of 11ß-hydroxysteroid dehydrogenase type 2, enhances the inhibitory effects of hydrocortisone in the treatment of osteosarcoma through Wnt/β-catenin pathway

BMC Pharmacology and Toxicology, 2023
Background The anti-osteosarcoma effects of hydrocortisone and thiram, an inhibitor of type 2 11ß-hydroxysteroid dehydrogenase (11HSD2), have not been reported.
You Zhang, Nanjing Li, He Li, Maojia Chen, Wei Jiang, Wenhao Guo   +5 more
doaj   +1 more source

Association of mortality with fludrocortisone addition to hydrocortisone treatment among septic shock patients: a propensity score matching analysis

Frontiers in Medicine, 2023
BackgroundSeveral clinical trials of corticosteroids have been carried out in the treatment of septic shock, however, the therapeutic effect of the most widely used hydrocortisone is still controversial, and no studies have directly compared ...
Xiaoxiao Cheng, Zhiqin Fu, Yiting Liu, Xiaoyu Zheng, Tianyang Hu   +4 more
doaj   +1 more source

Hydrocortisone fails to abolish NF-κB1 protein nuclear translocation in deletion allele carriers of the NFKB1 promoter polymorphism (-94ins/delATTG) and is associated with increased 30-day mortality in septic shock. [PDF]

PLoS ONE, 2014
BACKGROUND:Previous investigations and meta-analyses on the effect of glucocorticoids on mortality in septic shock revealed mixed results. This heterogeneity might be evoked by genetic variations. Such candidate is a promoter polymorphism (-94ins/delATTG)
Simon T Schäfer, Sophia Gessner, André Scherag, Katharina Rump, Ulrich H Frey, Winfried Siffert, Astrid M Westendorf, Jörg Steinmann, Jürgen Peters, Michael Adamzik   +9 more
doaj   +1 more source