Results 21 to 30 of about 96,745 (297)

Association of mortality with fludrocortisone addition to hydrocortisone treatment among septic shock patients: a propensity score matching analysis

Frontiers in Medicine, 2023
BackgroundSeveral clinical trials of corticosteroids have been carried out in the treatment of septic shock, however, the therapeutic effect of the most widely used hydrocortisone is still controversial, and no studies have directly compared ...
Xiaoxiao Cheng, Zhiqin Fu, Yiting Liu, Xiaoyu Zheng, Tianyang Hu   +4 more
doaj   +1 more source

Hydrocortisone fails to abolish NF-κB1 protein nuclear translocation in deletion allele carriers of the NFKB1 promoter polymorphism (-94ins/delATTG) and is associated with increased 30-day mortality in septic shock. [PDF]

PLoS ONE, 2014
BACKGROUND:Previous investigations and meta-analyses on the effect of glucocorticoids on mortality in septic shock revealed mixed results. This heterogeneity might be evoked by genetic variations. Such candidate is a promoter polymorphism (-94ins/delATTG)
Simon T Schäfer, Sophia Gessner, André Scherag, Katharina Rump, Ulrich H Frey, Winfried Siffert, Astrid M Westendorf, Jörg Steinmann, Jürgen Peters, Michael Adamzik   +9 more
doaj   +1 more source

Hydrocortisone-Loaded Lipid–Polymer Hybrid Nanoparticles for Controlled Topical Delivery: Formulation Design Optimization and In Vitro and In Vivo Appraisal

, 2023
The barrier functionalities of the skin offer a major but not insuperable hindrance for fabrication of skin delivery effective systems. This work aimed to develop an optimized lipid polymer hybrid nanoparticle and assess the skin delivery effectiveness ...
Mohammed Elmowafy (7447502), Diaa Massoud (5819519), Omar Awad Alsaidan (14929101), Abdulsalam M. Kassem (15665496), Sami I. Alzarea (14055507), Mohamed F. Ibrahim (12296130), Khaled Shalaby (13855357)   +6 more
core   +1 more source

Hydrocortisone therapy for patients with septic shock [PDF]

, 2008
Background Hydrocortisone is widely used in patients with septic shock even though a survival benefit has been reported only in patients who remained hypotensive after fluid and vasopressor resuscitation and whose plasma cortisol levels did not rise ...
Sprung, Charles L, Sprung, Charles L., Benbenishy, Julie, Briegel, Josef, Kalenka, Armin, Freivogel, Klaus, Payen, Didier, Reinhart, Konrad, Forst, Helmuth, Annane, Djillali, Singer, Mervyn, Benbenishty, Julie, Moreno, Rui, Weiss, Yoram G, Laterre, Pierre-Francois, Cuthbertson, Brian, Keh, Didier, Cuthbertson, Brian H, Weiss, Yoram G., CORTICUS Study Group   +19 more
core   +1 more source

Evaluation of prophylactic intravenous hydrocortisone for the prevention of postdural puncture headache following spinal anesthesia for cesarean section

Journal of Clinical Sciences, 2020
Context: Postdural puncture headache (PDPH) is a common complication following spinal anesthesia. No medication is currently used on routine basis for its prevention despite its high incidence.
Alaba Olusola Ogunsiji, Babatunde Babasola Osinaike, Simbo Daisy Amanor-Boadu, Gbolahan Oladele Obajimi   +3 more
doaj   +1 more source

Effect of stress doses of hydrocortisone on S-100B vs. interleukin-8 and polymorphonuclear elastase levels in human septic shock [PDF]

, 2005
Stress doses of hydrocortisone a re known to have immunomodulatory effects in patients with hyperdynamic septic shock. The prognosis correlates with the presence and severity of septic encephalopathy. However, neurological evaluation is influenced by the
Briegel, Josef, Mussack, Thomas, Jochum, Marianne, Schelling, Gustav, Biberthaler, Peter   +4 more
core   +1 more source

Cutaneous Permeation of a Percutaneously Applied Glucocorticoid Using Plant-Based Anionic Phospholipids in Hydrogenated Vegetable Oil: A Preliminary Study

Medicina, 2022
Purpose: It is important that, when corticosteroids are used therapeutically, concentrations be reduced as much as possible to mitigate potential adverse events and side effects.
Jack V. Greiner, Hridaya N. Bhargava, Thomas Glonek, Donald R. Korb, Michael E. Lindsay, Paula J. Oliver   +5 more
doaj   +1 more source

Transcriptome modulation by hydrocortisone in severe burn shock: ancillary analysis of a prospective randomized trial

Critical Care, 2017
Background Despite shortening vasopressor use in shock, hydrocortisone administration remains controversial, with potential harm to the immune system. Few studies have assessed the impact of hydrocortisone on the transcriptional response in shock, and we
Jonathan Plassais, Fabienne Venet, Marie-Angélique Cazalis, Diane Le Quang, Alexandre Pachot, Guillaume Monneret, Sylvie Tissot, Julien Textoris   +7 more
doaj   +1 more source

Immediate-Type Hypersensitivity to Succinylated Corticosteroids [PDF]

, 2010
Background: Despite their frequent use, systemic corticosteroids have rarely elicited immediate-type reactions. Objective: We report two male patients, aged 26 and 70 years, respectively, with severe immediate-type hypersensitivity secondary to the ...
Raewer, Helen-Caroline, Helen-Caroline Räwer, Wolfgang Sieber, Sieber, Wolfgang, Walker, Annett Isabel, Annett Isabel Walker, Przybilla, Bernhard, Bernhard Przybilla   +7 more
core   +1 more source

A study of impurity profiling via method development and force degradation in hydrocortisone butyrate at low concentration

Future Journal of Pharmaceutical Sciences, 2023
Background Since long, triamcinolone and fluocinolone, fluorinated derivatives, have been used for treating various types of dermatitis. Rosacea and perioral dermatitis are the most common side effects observed with prolonged use of fluorinated ...
Harshwardhan G. Gunjal, Vivek V. Byahatti   +1 more
doaj   +1 more source