Results 41 to 50 of about 96,745 (297)

Patient and caregiver experiences with hydrocortisone injections in adrenal crisis: a mixed-methods cross-sectional study

Frontiers in Endocrinology
BackgroundAdrenal crisis is the leading cause of death in patients with adrenal insufficiency, and prevention requires immediate parenteral hydrocortisone administration. However, most patients do not receive their home emergency hydrocortisone injection.
Sofia Llahana, Julia Anthony, Kyriakie Sarafoglou, Kyriakie Sarafoglou, Mitchell E. Geffner, Richard Ross   +5 more
doaj   +1 more source

Pulmonary Effects of Neonatal Hydrocortisone Treatment in Ventilator-Dependent Preterm Infants

International Journal of Pediatrics, 2011
Background/Objective. Hydrocortisone, administered to ventilated preterm neonates to facilitate extubation, has no adverse long-term effects, but short-term pulmonary effects have not been described previously.
Sandra E. A. de Jong, Floris Groenendaal, Frank van Bel, Karin J. Rademaker   +3 more
doaj   +1 more source

Effects of low-dose hydrocortisone and hydrocortisone plus fludrocortisone in adults with septic shock: a protocol for a systematic review and meta-analysis of individual participant data

BMJ Open, 2020
Introduction The benefits and risks of low-dose hydrocortisone in patients with septic shock have been investigated in numerous randomised controlled trials and trial-level meta-analyses. Yet, the routine use of this treatment remains controversial.
Yaseen Arabi, Sylvie Chevret, Laurent Billot, Anthony Gordon, Didier Keh, Romain Pirracchio, Balasubramanian Venkatesh, Djillali Annane, Andre Waschka, Jeremy Cohen, Simon Finfer, Naomi Hammond, John Myburgh, Anthony Delaney, Pierre Edouard Bollaert, Josef Briegel, Ling Liu, G Umberto, Liliana Mirea, L Charles, Nejla Tilouche, Surat Tongyoo, Ruiqiang Zheng   +22 more
doaj   +1 more source

Accuracy of hydrocortisone dose administration via nasogastric tube [PDF]

, 2018
OBJECTIVE: Hydrocortisone via nasogastric (NG) tube is used in sick children with adrenal insufficiency; however, there is no licensed formulation for NG administration.
Daniel, E., Whitaker, M.J., Keevil, B., Eleni Daniel, Ross, R.J., Martin J. Whitaker, Jerry Wales, Richard J. Ross, Brian Keevil, Wales, J.   +9 more
core   +1 more source

Hydrocortisone to Improve Survival without Bronchopulmonary Dysplasia [PDF]

, 2022
BACKGROUND Bronchopulmonary dysplasia is a prevalent complication after extremely preterm birth. Inflammation with mechanical ventilation may contribute to its development.
Hogden, Laurie A, Kennedy, Kathleen A., Meyer, Lauritz R., Peralta-Carcelen, Myriam, Patel, Ravi M., Khan, Amir M, McDavid, Georgia E, Watterberg, Kristi L., Keszler, Martin, Harmon, Heidi M., Hogden, Laurie A., Lowe, Jean R, Bell, Edward F., Maitre, Nathalie L., Crawford, Margaret M, Maitre, Nathalie L, Natarajan, Girija, Truog, William E., Adams-Chapman, Ira, DeMauro, Sara B, Purdy, Isabell B, D\u27Angio, Carl T, Cotten, C Michael, Higgins, Rosemary D, Wilson-Costello, Deanne E, McGowan, Elisabeth C., Watterberg, Kristi L, Walsh, Michele C, McGowan, Elisabeth C, Yoder, Bradley A, Purdy, Isabell B., Truog, William E, Walsh, Michele C., Harmon, Heidi M, Reynolds, Anne M, Mosquera, Ricardo A, Higgins, Rosemary D., Hintz, Susan R, Van Meurs, Krisa P, Wilson-Costello, Deanne E., Schmidt, Barbara, Chess, Patricia R., McDavid, Georgia E., Reynolds, Anne M., Van Meurs, Krisa P., Bell, Edward F, Hibbs, Anna Maria, Winter, Sarah, Kennedy, Kathleen A, Backstrom-Lacy, Conra, Heyne, Roy J, Ambalavanan, Namasivayam, Goldberg, Ronald N, Sokol, Gregory M., Merhar, Stephanie, Yoder, Bradley A., Goldberg, Ronald N., D’Angio, Carl T., Cotten, C. Michael, Sokol, Gregory M, Wyckoff, Myra H, Wyckoff, Myra H., Moallem, Mohannad, Hintz, Susan R., Mosquera, Ricardo A., Lowe, Jean R., D’Angio, Carl T, Chess, Patricia R, Malcolm, William F, Poindexter, Brenda B., Kilbride, Howard W., Laughon, Matthew M., DeMauro, Sara B., Hines, Abbey C., Chawla, Sanjay, Khan, Amir M., Garg, Meena, Laughon, Matthew M, Hines, Abbey C, Crawford, Margaret M., Eunice Kennedy Shriver NICHD Neonatal Research Network, Poindexter, Brenda B, Malcolm, William F., Das, Abhik, Heyne, Roy J., Meyer, Lauritz R, Patel, Ravi M, Li, Lei, Kilbride, Howard W   +88 more
core   +1 more source

Pharmacokinetic Modeling of Hydrocortisone by Including Protein Binding to Corticosteroid-Binding Globulin

Pharmaceutics, 2022
Background: Patients with adrenal insufficiency are treated with oral hydrocortisone (HC) to compensate for the loss of endogenous cortisol production. Intrinsic imperfections of cortisol replacement strategies in mimicking normal cortisol secretion are ...
Eric Rozenveld, Nieko Punt, Martijn van Faassen, André P. van Beek, Daan J. Touw   +4 more
doaj   +1 more source

Concomitant arginine-vasopressin and hydrocortisone therapy in severe septic shock: association with mortality [PDF]

, 2011
To evaluate the association between concomitant arginine-vasopressin (AVP)/hydrocortisone therapy and mortality in severe septic shock ...
Schmittinger, Christian A, Günter Luckner, Dünser, Martin W, Hanno Ulmer, Daniel C. H. Schröder, Schröder, Daniel C H, Ulmer, Hanno, Rex, Christopher, Christian Torgersen, Torgersen, Christian, Christian A. Schmittinger, Christopher Rex, Luckner, Günter, Martin W. Dünser   +13 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source