Results 61 to 70 of about 103,469 (251)

Concomitant arginine-vasopressin and hydrocortisone therapy in severe septic shock: association with mortality [PDF]

, 2011
To evaluate the association between concomitant arginine-vasopressin (AVP)/hydrocortisone therapy and mortality in severe septic shock ...
Schmittinger, Christian A, Günter Luckner, Dünser, Martin W, Hanno Ulmer, Daniel C. H. Schröder, Schröder, Daniel C H, Ulmer, Hanno, Rex, Christopher, Christian Torgersen, Torgersen, Christian, Christian A. Schmittinger, Christopher Rex, Luckner, Günter, Martin W. Dünser   +13 more
core   +2 more sources

Large‐scale Whole‐Exome Sequencing Defines the Protein‐Coding Architecture of Retinal Structure, Visual Function, and Major Blinding Diseases

Advanced Science, EarlyView.
Large‐scale whole‐exome sequencing in 356,982 UK Biobank participants defines the protein‐coding architecture of retinal structure, visual function, and major blinding diseases. Pleiotropic genes, including CFI, C3, and RIOX1, bridge multiple retinal phenotypes, while experimental validation of FYB2 implicates RPE barrier dysfunction, providing ...
Jianqing Li, Yijun Ge, Jingxiao Du, Liu Yang, Bangsheng Wu, Chenyue Hang, Mengxi Shen, Yimin Mao, Ting Zhang, Qiyu Bo, Tianyuan Zhao, Yutian Jiao, Yazhi Wang, Shunxiang Gao, Jieqiong Chen, Junran Sun, Tong Li, Huixun Jia, Yang Dou, Wei Cheng, Xiaoling Wan, Jintai Yu, Xiaodong Sun, Bai Lu   +23 more
wiley   +1 more source

Comparison of Two Corticosteroid Pre-Infusion Regimens for Pegloticase in the United States: A Retrospective Analysis in Community Rheumatology Practices

Drugs - Real World Outcomes, 2019
Background Pegloticase is a recombinant porcine-like uricase enzyme that is FDA-approved for the treatment of chronic refractory gout in adults. Some patients receiving pegloticase develop anti-drug antibodies, which leads to both loss of pegloticase ...
Amar Majjhoo, Ada Kumar, Michael Zdanis, Brian LaMoreaux   +3 more
doaj   +1 more source

Leukocytosis After Intraperitoneal Hydrocortisone Instillation [PDF]

, 2020
Background: Laparoscopic surgery provides tremendous benefits to patients, including faster recovery, shorter hospital stay, and earlier return to normal activities and less immunologic impairments.
Amene Sabzi Sarvestani, Mehdi Zamiri
core  

Integrated Single‐Nucleus Multi‐Omics Atlases Reveal Lineage Plasticity and Regulatory Networks of Luminal Epithelial Cells During Mammary Gland Lactation and Involution

Advanced Science, EarlyView.
This study integrates single‐cell multi‐omics, spatial transcriptomics, and cross‐species comparative analyses to systematically characterize the cellular composition and differentiation trajectories of goat mammary epithelial cells, along with the gene regulatory networks and intercellular communication mechanisms governing these trajectories, thereby
Xiaoru Yan, Xiaoyu Mi, Guanghui Tan, Xinmei Li, Zhenliang Zhu, Zhenyu Wei, Huimei Fan, Yamei Wu, Tao Shi, Lingzhao Fang, Yuanpeng Gao, Yu Wang, Jun Liu   +12 more
wiley   +1 more source

Hydrocortisone and ulinastatin for miliary tuberculosis-induced septic shock and adult respiratory distress syndrome in the intensive care unit

CHRISMED Journal of Health and Research, 2020
Hydrocortisone and ulinastatin are anti-inflammatory agent. We hereby report the case of a patient of sputum-positive miliary pulmonary tuberculosis that developed adult respiratory distress syndrome with septic shock.
Niraj Kumar Keyal, Manish Nakarmi
doaj   +1 more source

A Case of Tumid Lupus Erythematosus Successfully Treated with Topical Tacrolimus and Hydrocortisone 17-Butyrate [PDF]

Tumid lupus erythematosus is an uncommon subtype of chronic cutaneous lupus erythematosus. Hereby, we report a 36-year-old male patient with tumid lupus erythematosus who presented with erythematous papules and plaques on the face and neck who showed ...
Funda Tamer, İrem Özdemir, Özlem Erdem, Betül Öğüt   +3 more
core   +1 more source

GM‐CSF Promotes Neutrophil PD‐L1 Expression Through the VEGFR‐2/STAT6/CSF2 Signaling Axis in Oral Squamous Cell Carcinoma

Advanced Science, EarlyView.
VEGFR‐2 signaling in OSCC activates Src–STAT6‐dependent CSF2 transcription, driving tumor‐derived GM‐CSF secretion. GM‐CSF programs neutrophils to express PD‐L1 through STAT5–mTOR/S6K signaling, suppressing cytotoxic CD8+ T cells. This pathway reveals a tumor–neutrophil immune checkpoint circuit that limits anti‐PD‐1 responsiveness in OSCC.
Fangxing Zhu, Yuanhe You, Yiyi Zhang, Yibin Dai, Xinyu Zhou, Yong Fu, Xi Lu, Yingying Huang, Zhihang Zhou, Ronghui Xia, Wutong Ju, Zhaoqi Yuan, Laiping Zhong, Tongchao Zhao   +13 more
wiley   +1 more source

Evaluation of Hydrocortisone Discontinuation Strategies in Septic Shock: A Retrospective Cohort Study

Critical Care Explorations
IMPORTANCE:. While corticosteroid administration in septic shock has been shown to reduce vasopressor requirements and accelerate shock reversal, the optimal discontinuation strategy remains unexplored. OBJECTIVES:.
Hanine O. AlMubayedh, PharmD, BCPS, BCCCP, Rayd A. AlMehizia, PharmD, BCCCP, Abdul Salam, PhD, Razan M. AlGhunaim, PharmD, BCCCP, Othman Mohammed, MD, Abdullah A. Alrbiaan, MD, Nada S. AlQadheeb, PharmD, BCCCP, FCCP, FCCM   +6 more
doaj   +1 more source

Skylab 3 Urinary Hydrocortisone Science Pilot

, 1973
A graph of biomedical data for Urinary Hydrocortisone levels, for the Science Pilot of Skylab 3, Owen K ...

core