Results 71 to 80 of about 103,469 (251)

A randomised placebo-controlled trial of oral hydrocortisone for treating tobacco withdrawal symptoms.

, 2011
RATIONALE: Many smokers experience a decline in cortisol to sub-normal levels during the first days of smoking cessation. A greater decline in cortisol is associated with more intense cigarette withdrawal symptoms, urge to smoke and relapse to smoking ...
Clow, Angela, Hucklebridge, F, Fuller, J., Reid, Fiona, Michael Ussher, Aveyard, P., Robert West, Phil Evans, West, R, Steptoe, A., West, R., Judith Ibison, Evans, P., Ussher, M, Fuller, Julie, Evans, P, Ibison, J., Clow, A, Ibison, J, Aveyard, P, Hucklebridge, Frank, Frank Hucklebridge, Andrew Steptoe, West, Robert, Clow, A., Fiona Reid, Reid, F, Fuller, J, Paul Aveyard, Steptoe, A, Ussher, M., Reid, F., Steptoe, Andrew, Ussher, Michael, Hucklebridge, F., Angela Clow, Ibison, Judith, Evans, Phil, Julie Fuller, Aveyard, Paul   +39 more
core   +1 more source

Chimeric IL‐6/4R‐LL37 Engineered Macrophages Achieve Synchronized Inflammation Control and Antimicrobial Defence in Sepsis

Advanced Science, EarlyView.
Engineered macrophages programmed in situ by LNP‐delivered IL‐6/4 fusion and LL37 mRNAs simultaneously dampen cytokine storm, promote M2‐like repair, and enhance direct bacterial killing in sepsis. This combinatorial strategy restores T cell and macrophage function, lowers organ bacterial burden, and improves survival, highlighting a precision, host ...
Tianyang Jie, Zheyu Zhang, Hao Zhang, Linke Bian, Penglong Zheng, Sijia Zhou, Minqi Wang, Mingyu Qu, Yufei Wang, Xinhua Qu, Bing Yue   +10 more
wiley   +1 more source

Hydrocortisone dose in adrenal insufficiency:Balancing harms and benefits [PDF]

, 2017
Patients with secondary adrenal insufficiency do not produce cortisol and are therefore treated with hydrocortisone tablets. The optimal substitution dose for hydrocortisone is unknown.
Werumeus Buning, Jorien
core   +15 more sources

Hydrocortisone treatment is associated with early recovery from severe septic shock in patients with obstructive pyelonephritis due to upper urinary tract stone

BJUI Compass
Objectives The administration of hydrocortisone in patients with severe septic shock contributes to early recovery in intensive care. The purpose of this study was to evaluate the effect of hydrocortisone on early recovery from severe septic shock in ...
Isamu Otsuka, Koshiro Nishimoto, Taichi Kozako, Katsuhiro Kanemaru, Yasuhiro Yamashita, Toshiyuki Kamoto, Atsuro Sawada   +6 more
doaj   +1 more source

Biochemically Constrained Multi‐Omics Integration Reveals Protein–Metabolite Dependencies Across Diseases

Advanced Science, EarlyView.
ProMetNet introduces a biologically constrained deep learning framework for proteo‐metabolomic integration by embedding Reactome‐derived pathway topology into neural networks. It captures non‐linear molecular dependencies and pathway‐level metabolic reorganization, enabling interpretable discrimination.
Minghui Zhao, Na Zhou, Ruotong Liu, Xiaofei Li, Jian Li, Fuzhong Xue, Qingzhen Hou   +6 more
wiley   +1 more source

Prescription pattern of oral hydrocortisone by Indian healthcare professionals: An online questionnaire-based survey

Endocrine Regulations
Objective. Adrenal insufficiency is predominantly managed by glucocorticoids, from which hydrocortisone is most frequently prescribed. However, limited data are available on prescription patterns among Indian healthcare professionals (HCPs).
Valia Rama, Jangir Ashish Kumar, Sahu Danendra, Menon Jayakrishnan C, Varghese Johann, Sundar Shyam, Yadav Anjana, Kamble Sanjay   +7 more
doaj   +1 more source

Polystyrene Nanoplastics Drive β‐Cell Dedifferentiation Through Dendritic Cell‐Intrinsic MHC‐I‐Dependent Inflammatory Crosstalk

Advanced Science, EarlyView.
Polystyrene nanoplastics disrupt pancreatic immune–endocrine homeostasis by promoting MHC‐I‐associated dendritic cell activation and inflammatory crosstalk with β cells. This immune remodeling drives β‐cell dedifferentiation, impairs insulin secretion, and aggravates metabolic dysfunction, revealing a previously unrecognized immunometabolic mechanism ...
Conghui Qiao, Yuqing Song, Fang Yang, Menghui Guo, Libin Jiang, Xiaoyue Quan, Wei Wei, Xinyang Wang, Tianshu Han, Mingyuan Liu, Wenbo Jiang   +10 more
wiley   +1 more source

Long-term administration of hydrocortisone: down-regulating the level of cytokine and resulting in injuring testicular tissue of juvenile mice

BMC Pharmacology and Toxicology
Background As an important glucocorticosteroid hydrocortisone has been widely used in clinical practice. Even though a series of side effects induced by long-term administration of hydrocortisone are known, but side effects related to testicular injury ...
Xiaoyi Zhang, Junhua Zhou, Yifan Yang, Yaonan Wang, Shurui Zhao, Jianhui Wu, Ming Zhao, Shiqi Peng   +7 more
doaj   +1 more source

Dual‐Organelle Secretome Conjugation and Organ‐Uptake Tracking (DuO‐SCOUT) Enables Deep and Sensitive Mapping of the Secreted Proteins

Advanced Science, EarlyView.
A novel dual‐organelle proximity labeling platform, DuO‐SCOUT, decodes the complex landscape of systemic organ‐organ communication by capturing both classical and unconventional secretomes. Application in metabolic models maps the adipose‐to‐brain secretory relay, identifying selective extra‐hypothalamic sites for adipose‐derived factors and expanding ...
Fenglian Yang, Rui Qian, Jiaxing Song, Xingqi Meng, Jin Young Kim, Kwok On Lai, Li Wang, Liang Zhang   +7 more
wiley   +1 more source

Effect of a combination of 0.001% hydrocortisone and 0.2% hyaluronic acid on conjunctival cytology in patients with dysregulatory inflammatory changes of the conjunctiva in type 2 diabetes

Ukrainian Journal of Ophthalmology
Purpose. To assess and evaluate cytological changes of conjunctival epithelial cells collected by CIC and relative expression of CD15 before and after 2-month treatment with sodium hyaluronate 0.2% and 0.001% hydrocortisone among patients with ...
T. Zhmud, S. Barabino, G. Drozhzhyna
doaj   +1 more source