Results 181 to 190 of about 103,076 (260)
Brain Pathology, EarlyView.Target‐enriched enzymatic methylation sequencing (TEEM‐seq), a DNA methylation sequencing method using the Twist Human Methylome panel, shows comparable performance to array‐based tumor methylation profiling. The method is compatible with both frozen and formalin‐fixed paraffin‐embedded (FFPE) samples and is a viable approach to tumor methylation and ...
Quynh T. Tran +6 more
wiley +1 more source
Treatment options for immune‐related adverse events associated with immune checkpoint inhibitors
British Journal of Pharmacology, EarlyView.Abstract The immunotherapy revolution with the use of immune checkpoint inhibitors (ICIs) started with the clinical use of the first ICI, ipilimumab, in 2011. Since then, the field of ICI therapy has rapidly expanded — with the FDA approval of 10 different ICI drugs so far and their incorporation into the therapeutic regimens of a range of malignancies.
Yu Hua Chen +3 more
wiley +1 more source
Characterisation of neurogenic lipolytic responses in white adipose tissue ex vivo
British Journal of Pharmacology, Volume 182, Issue 9, Page 1975-1988, May 2025.Background and Purpose Dysfunction of the autonomic nervous system is associated with cardiovascular dysfunction, including metabolic syndrome and obesity. Understanding mechanisms of neurogenic control of white adipose tissue is key to understanding adipose physiology and pathophysiology, though there is limited research exploring this in adipose ...
Kayleigh E. Goddard, Samuel J. Fountain
wiley +1 more source
British Journal of Pharmacology, EarlyView.Abstract Background and Purpose Nervonic acid plays a vital role in maintaining normal brain and neuronal function. Nervonic acid has gained increasing attention because of its potential neuroprotective and anti‐inflammatory properties. Nonetheless, the beneficial effects of nervonic acid are yet to be fully investigated. Adrenomyeloneuropathy (AMN), a
Chenxu Li +2 more
wiley +1 more source
Genomic profiles of patients with skin melanoma in the era of immune checkpoint inhibitors
Cancer Science, Volume 116, Issue 4, Page 1107-1114, April 2025.We investigated the genomic profiles of patients with skin melanoma who had received immune checkpoint inhibitors and explored associations with clinical features and outcomes via a large‐scale nationwide database in Japan (the C‐CAT database). Patients with multiple (two or more) liver metastases or brain metastases were more likely to have NOTCH3 or ...
Yao Liang +4 more
wiley +1 more source
Cancer Science, EarlyView.In advanced EGFR‐mutant NSCLC, high PD‐L1 expression may indicate reduced efficacy of third‐generation EGFR‐TKIs. PD‐L1 expression in primary lesions may serve as a prognostic marker, whereas expression in metastatic lymph nodes does not. This spatial heterogeneity could affect PD‐L1's predictive accuracy for third‐generation EGFR‐TKIs efficacy ...
Yidan Zhang +7 more
wiley +1 more source
Clinical Presentation of Congenital Hypopituitarism: Lessons From a Large Academic Centre
Clinical Endocrinology, Volume 102, Issue 6, Page 649-655, June 2025.ABSTRACT Objective Pituitary hormone deficiencies are associated with considerable morbidity, yet the variability of presentation and evolution of congenital hypopituitarism remains unexplored. This study investigated differences in presentation of congenital isolated pituitary hormone deficiency (cIPHD) versus congenital multiple pituitary hormone ...
Jennifer M. Ladd +4 more
wiley +1 more source
Clinical Endocrinology, Volume 102, Issue 6, Page 683-698, June 2025.ABSTRACT Context It is well recognised there is a high prevalence of pituitary dysfunction in childhood brain tumours survivors who are treated with radiotherapy. In contrast, the potential for survivors of brain tumours arising in adulthood to develop radiotherapy‐induced hypopituitarism may be underestimated.
Darran Mc Donald +7 more
wiley +1 more source