Results 141 to 150 of about 47,664 (260)

Phase II Trial of Nivolumab in Advanced Solid Tumors Based on Genomic Profiling: BELIEVE Trial (NCCH1901) Subcohort

Cancer Science, EarlyView.
Off‐label nivolumab treatment guided by CGP results was evaluated in 56 patients with advanced solid tumors. TMB‐High was the predominant biomarker leading to nivolumab treatment. Nivolumab showed limited clinical benefit in 50 patients with measurable disease, with an ORR of 16.0%, DCR of 40.0%, median PFS of 2.7 months, and median OS of 7.2 months ...
Masashi Kanai, Kuniko Sunami, Tatsunori Shimoi, Satoshi Nishiwaki, Ichiro Kinoshita, Tetsuhiro Yoshinami, Chigusa Morizane, Yusuke Sato, Toshio Kubo, Mamoru Ito, Hiroshi Nishihara, Toru Mukohara, Hidekazu Shirota, Ryo Ko, Taro Shibata, Manabu Muto, Noboru Yamamoto   +16 more
wiley   +1 more source

The Clinical Impact of Corticosteroid Supplementation in Febrile Patients with Adrenal Insufficiency. [PDF]

Yonsei Med J
Kwon H, Lee SE, Park JH, Ko JW, Kim B.
europepmc   +1 more source

Hypogonadotropic Hypogonadism Before and After Transsphenoidal Surgery for Non‐Functioning Pituitary Adenoma

Clinical Endocrinology, EarlyView.
ABSTRACT Objective The effect of transsphenoidal surgery (TSS) on the hypothalamic‐pituitary‐gonadal (HPG) axis in patients with non‐functioning pituitary adenomas (NFPA) is underexplored, especially in women. Our aim was to investigate the HPG axis function before and after TSS, its association with quality of life (QoL), and to identify factors that ...
Victor Hantelius, Gudmundur Johannsson, Sofie Jakobsson, Erik Thurin, Tobias Hallen, Thomas Skoglund, Oskar Ragnarsson   +6 more
wiley   +1 more source

Rare coexistence of aldosterone resistance and adrenal insufficiency in asymptomatic infant with persistent hyperkalaemia: A case report. [PDF]

World J Clin Pediatr
Wan-Nik FH, Zulkeflee HA, Ab Rahim NS, Tuan-Ismail ST.   +3 more
europepmc   +1 more source

Challenges in Diagnosing Central Adrenal Insufficiency in Children: Cortisol‐Stimulating Tests are Safe and Often Required

Clinical Endocrinology, EarlyView.
ABSTRACT Introduction The accuracy and safety of cortisol‐stimulating tests (CSTs) for assessing hypothalamic–pituitary–adrenal (HPA) axis integrity, including the diagnosis of central adrenal insufficiency (CAI), in children remain uncertain. Although these tests can simultaneously evaluate cortisol and growth hormone secretion, the present study ...
Mariana Peduti Halah, Ana Carolina Maia Teodózio, Davi Casale Aragon, Paula Conde Lamparelli Elias, Margaret de Castro, Ayrton Custodio Moreira, Sonir Rauber Antonini   +6 more
wiley   +1 more source

Addisonian crisis following osteoprotective therapy in a patient with secondary adrenal insufficiency. [PDF]

JCEM Case Rep
Al Nour AH, Elgaafary S, Rink P, Pannier J, Behre G.   +4 more
europepmc   +1 more source

Impact of Osilodrostat on Health‐Related Quality of Life in Cushing's Disease: Analysis of Patient‐Reported Outcomes From the Phase III LINC 3 and LINC 4 Clinical Trials

Clinical Endocrinology, EarlyView.
ABSTRACT Objective Evaluate the effects of osilodrostat short‐ and long‐term treatment on health‐related quality of life (HRQoL) in Cushing's disease. Design LINC 3 and LINC 4 studies (pooled analysis). Patients 185 patients (mean baseline total scores: Cushing's Quality of Life [CushingQoL], 44.0; Beck Depression Inventory II [BDI‐II], 15.6; EuroQol ...
John Newell‐Price, Beverly M. K. Biller, Maria Fleseriu, Beatrice Gueron, Grzegorz Binowski, Anna Paćkowska, Mônica R. Gadelha   +6 more
wiley   +1 more source

Primary adrenal insufficiency and autoimmune thyroiditis in an adolescent with Castleman-TAFRO syndrome. [PDF]

JCEM Case Rep
Mustafa M, Aaron VD, Overholt K, Tuttle A.   +3 more
europepmc   +1 more source

THE HYPERCALCEMIA OF ADRENAL INSUFFICIENCY* [PDF]

Journal of Clinical Investigation, 1963
M, WALSER, B H, ROBINSON, J W, DUCKETT
openaire   +2 more sources

Refractory hyponatremia after traumatic brain injury unmasks adrenal insufficiency in a patient with remote steroid use. [PDF]

CEN Case Rep
Ozeki T, Ito S, Muto Y, Nagase F, Iwasaki K, Ito Y, Ikai H, Yamamoto M, Yokoyama-Kokuryo W, Fujita Y.   +9 more
europepmc   +1 more source