Results 91 to 100 of about 114,029 (285)

Clinical Safety of Extended Interval Dosing of Nivolumab in Patients with Melanoma

Clinical Pharmacology &Therapeutics, EarlyView.
Extended interval dosing regimens of immune checkpoint inhibitors have been implemented widely. However, their approval was mainly based on pharmacokinetic modeling and simulations. Consequently, comparative safety data of extended interval dosing regimens in a real‐world setting are limited.
Ruben Malmberg, Maaike M. Hofman, Fatima Ashad, Alaa Daloul, Stefani Oosterveld, Edwin A. Basak, Esther Oomen‐de Hoop, Astrid A. M. van der Veldt, Arjen Joosse, Roelof W. F. van Leeuwen, Ron H. J. Mathijssen   +10 more
wiley   +1 more source

More Than a Question of Correlation: Characterization of the Evidentiary Basis for Biomarker Surrogates Used in European Marketing Authorizations

Clinical Pharmacology &Therapeutics, EarlyView.
Traditionally, clinical outcomes measuring how a patient feels, functions, or survives are preferred endpoints in clinical trials; however, some may take a long time to manifest in slowly developing diseases. Biomarkers, if properly validated, can serve as surrogate endpoints, acting as substitutes for clinical outcomes.
Renske Johanna Grupstra, Viktoriia Starokozhko, Elisabeth Bakker, Anna Maria Gerdina Pasmooij, Peter Gerardus Maria Mol   +4 more
wiley   +1 more source

Adrenal tumors. Literature review

Acta Médica del Centro, 2014
Tumors of adrenal origin may be derived from the cortex or the medulla, which depends on the type of functionality that can be developed. Adrenal masses have varying styles.
Vivian de la Caridad Betancourt Rodríguez, Emma Ivette Carolina Archila López   +1 more
doaj  

Case report: Imaging of adrenal adenomatoid tumors: reports of two cases and review of literature

Frontiers in Oncology
Adenomatoid tumors (ATs) are uncommon, benign tumors of mesothelial origin, most frequently found in the genital tracts of both sexes. Extragenital localization sites, such as adrenal glands, are extremely rare.
Yuanyuan Wu, Dongliang Hu, Manman Cui, Yan Liu, Xiuzhi Zhou, Duchang Zhai, Guohua Fan, Wu Cai   +7 more
doaj   +1 more source

Expressions of LncRNA HOTAIR and VEGF in adrenal malignant tumors and their prognostic significance

Linchuang shenzangbing zazhi, 2021
Objective To explore the expression levels of long non-coding RNAHOX transcript antisense intergenic RNA（LncRNAHOTAIR）and vascular endothelial growth factor（VEGF）in patients with adrenal malignant tumor,and analyze their prognostic relationship.Methods ...
Du Xue-qian, Sun Qing-feng, Tian Long-jiang   +2 more
doaj  

Steroidogenic Factor 1 (SF1) Immunohistochemical Stain Is Sensitive and Specific for the Cytopathologic Identification of Intrapancreatic Ectopic Splenic Tissue

Diagnostic Cytopathology, EarlyView.
ABSTRACT Background Accessory spleens result from failure of splenic fusion during development and are occasionally located in the pancreatic tail, radiographically appearing as solid or solid/cystic lesions. Fine needle aspiration (FNA) easily identifies accessory spleens in most samples based on architecture and using CD8 to highlight splenic ...
Adeyinka Akinsanya, Jessica L. Muldoon, Mohamed Mustafa, Bin Yang, Hector Mesa, Omer Saeed   +5 more
wiley   +1 more source

Case Report: Adrenal schwannoma associated with ganglioneuroma

Frontiers in Surgery
BackgroundAn adrenal collision tumor (ACT) denotes the presence of distinct tumors with diverse behavioral, genetic, and histological features independently co-existing within the adrenal tissue without intermingling, and occurrences of such cases are ...
Dong-Lin He, Run-lin Feng, Jia-gui Chai, Xin Guo, Chang-xing Ke   +4 more
doaj   +1 more source

Integrative multi-omics analysis identifies a prognostic miRNA signature and a targetable miR-21-3p/TSC2/ mTOR axis in metastatic pheochromocytoma/ paraganglioma [PDF]

, 2019
Artículo escrito por un elevado número de autores, solo se referencian el que aparece en primer lugar y los autores pertenecientes a la UAMPheochromocytomas and paragangliomas (PPGLs) are rare neuroendocrine tumors that present variable outcomes.
Alvarez - Escola, Cristina, Calsina, Bruna   +1 more
core   +2 more sources

Rodent monocyte‐derived macrophages do not express CD163: Comparative analysis using macrophages from living boreoeutherians

Developmental Dynamics, EarlyView.
Abstract Background CD163 is a scavenger receptor predominantly expressed on the surfaces of macrophages in various mammalian species and is a marker of anti‐inflammatory (M2‐like) macrophages. High density of CD163‐positive tumor‐associated macrophages (TAMs) is associated with worse prognosis in various patient tumors.
Yoichi Saito, Yukio Fujiwara, Yasuka L. Yamaguchi, Satomi S. Tanaka, Kyoko Miura, Yoshiyuki Hizukuri, Kyoko Yamashiro, Yasuhiro Hayashi, Yuta Nakashima, Yoshihiro Komohara   +9 more
wiley   +1 more source

An incidental large adrenal schwannoma: A case report

Radiology Case Reports
Adrenal schwannoma is a rare tumor of Schwann cell origin that represents less than 0.2% of all adrenal tumors. These typically benign tumors are most often found in the head, neck, and limbs.
Ryan C. Rizk, MS, Mohammad Yasrab, MD, Linda C. Chu, MD, Edmund M. Weisberg, MS, MBE, Elliot K. Fishman, MD   +4 more
doaj   +1 more source