Results 31 to 40 of about 60,136 (255)
Synthesis, Spectroscopic, and Biological Assessments on Some New Rare Earth Metal Adrenaline Adducts
Crystals, 2021 Adrenaline (Adr) reacts with chlorides of Y3+, Ce3+, Nd3+ and Sm3+ in methanol at 60 °C to yield metal ion adducts of definite composition. These compounds are characterized by elemental analyses, molar conductivity, UV-Vis., 1H–NMR, Raman laser ...
Sulaiman A. Al Yousef +8 more
doaj +1 more source
Synthesis and Characterization of Photoswitchable Covalent Ligands for the β2‐Adrenoceptor
Angewandte Chemie, EarlyView.A structure‐based design of a covalent photoswitchable ligand for the β2‐adrenergic receptor, a therapeutically relevant GPCR, is described. This tool facilitates the modification of the intrinsic activity of the protein by light. Computational analysis of its mechanism of action suggests that the photoswitch takes place within the binding pocket ...
Ulrike Wirth +9 more
wiley +2 more sources
Doc2B acts as a calcium sensor for vesicle priming requiring synaptotagmin-1, Munc13-2 and SNAREs
eLife, 2017 Doc2B is a cytosolic protein with binding sites for Munc13 and Tctex-1 (dynein light chain), and two C2-domains that bind to phospholipids, Ca2+ and SNAREs.
Sébastien Houy +5 more
doaj +1 more source
Rheumatology, 2022 Introduction Low back pain (LBP) is the most common ailment in patients with lumbar spine osteoarthritis (OA). There are many methods to treat LBP, such as manual therapy, osteopathy, massage, physical exercise, and physical therapy.
Marta Barłowska-Trybulec +3 more
doaj +1 more source
Central command: Feedforward control of the sympathoadrenal system during exercise
Journal of Physical Fitness and Sports Medicine, 2012 Feedforward control by higher brain centers (central command) plays a role in autonomic regulation of the cardiovascular system during exercise. To reveal central control of cardiac autonomic outflows, a series of experiments have been conducted in our ...
Kanji Matsukawa, Nan Liang, Kei Ishii
doaj +1 more source
Integrated Environmental Assessment and Management, Volume 19, Issue 1, Page 63-82, January 2023., 2023 Abstract This review examines the presence and evolution of thyroid‐like systems in selected aquatic invertebrates to determine the potential use of these organisms in screens for vertebrate thyroid hormone axis disrupting chemicals (THADCs). Such a screen might support the phasing out of some vertebrate testing.
Jane E. Morthorst +4 more
wiley +1 more source
Advanced Science, EarlyView.A single dual‐emission two‐photon fluorescent probe is designed for simultaneously tracking tyrosinase (TYR) and adenosine triphosphate (ATP). With the help of this probe, the intricate correlation and regulatory mechanism between TYR and ATP during oxidative stress is uncovered.
Hong Huang +12 more
wiley +1 more source
Advanced Science, EarlyView.Occlusion of tumor blood vessels represents a promising yet challenging approach in cancer treatment. Herein, supramolecularly engineered platelets conjugated with morphology‐transformable nanoparticles is developed for precise tumor embolization. The engineered platelets actively accumulate at tumor sites following induced blood vessel injury.
Junyan Li +9 more
wiley +1 more source
Development of MDM2‐Targeting PROTAC for Advancing Bone Regeneration
Advanced Science, EarlyView.This work presents a creative pipeline for developing MDM2‐targeting PROTACs (MDM2‐PROTACs) for application in bone regeneration. The developed PROTACs (CL144 and CL174) are validated for their degradation efficiency and osteogenic effects in human BMSCs.
Sol Jeong +17 more
wiley +1 more source
Standard energy data competition procedure: A comprehensive review with a case study of the ADRENALIN load disaggregation competition [PDF]
Energy Informatics. EI.A 2023. Lecture Notes in Computer Science,
vol 14467Crowdsourcing data science competitions has become popular as a cost-effective alternative to solving complex energy-related challenges. How-ever, comprehensive reviews on hosting processes remain scarce. Therefore, this paper undertakes a detailed review of 33 existing data competitions and 12 hosting platforms, complemented by an in-depth case study ...
arxiv +1 more source