Results 91 to 100 of about 186,020 (321)

Analytical and Pharmacological Characterization of 1‐(Furan‐2‐Carbonyl)‐LSD (1F‐LSD) and Comparison With 1‐(Thiophene‐2‐Carbonyl)‐LSD (1T‐LSD)

open access: yesDrug Testing and Analysis, EarlyView.
The novel lysergamide 1‐(furan‐2‐carbonyl)‐LSD (1F‐LSD) was analytically characterized. 1F‐LSD showed LSD‐like activity in vivo similar to 1‐(thiophene‐2‐carbonyl)‐LSD (1T‐LSD) used for comparison. Administration studies in mice and LC–MS analysis revealed that 1F‐LSD served as a prodrug.
Simon D. Brandt   +5 more
wiley   +1 more source

Comparing the effects of intravenous injection and intranasal atomisation of detomidine in sheep

open access: yesVeterinary Medicine and Science, Volume 9, Issue 1, Page 353-362, January 2023., 2023
This paper compares the intravenous and intranasal routs of Detomidine administration in sheep. Abstract Background Detomidine is an α‐2 agonist sedative drug which reduces the release of norepinephrine in nerves. Administering this drug through intranasal (IN) route could cause direct transmission to the central nervous system.
Touran Tahmasbi   +3 more
wiley   +1 more source

Effects of Dimenhydrinate on Motor Behavior and Vascular Function: Possible Implications for the Field of Sports

open access: yesDrug Testing and Analysis, EarlyView.
Regarding cardiovascular effects, DMH decreased vascular reactivity to phenylephrine and acetylcholine. We observed that the combination of DPH and 8‐Cl‐T was identified as the responsible for increasing blood pressure and heart rate in the biological model used.
Jazmín Flores‐Monroy   +3 more
wiley   +1 more source

Markers for internal neoplasia in the horse

open access: yesVeterinary Medicine and Science, Volume 9, Issue 1, Page 132-143, January 2023., 2023
The measurement of tumour markers in horses should be performed only in risk groups or in patients with suspicious clinical/laboratory findings (paraneoplastic syndromes). The results should be interpreted with caution as many factors (e.g., young age, pregnancy and inflammation) affect their concentration or activity.
Karolina Drozdzewska, Heidrun Gehlen
wiley   +1 more source

Urology Residency Directors' Awareness of Association between α-Adrenergic Antagonists and Floppy Iris Syndrome and Practice Patterns Regarding Prophylactic α-Adrenergic Antagonists

open access: yesJournal of Academic Ophthalmology, 2019
Purpose The use of prophylactic α-adrenergic receptor antagonists prior to surgery is associated with reduced postoperative urinary retention. However, α-adrenergic receptor antagonists have been associated with intraoperative floppy iris syndrome (IFIS).
David Cui   +2 more
doaj   +1 more source

Frailty determinants in heart failure: Inflammatory markers, cognitive impairment and psychosocial interaction

open access: yesESC Heart Failure, EarlyView.
Abstract Aims This study aimed to identify factors associated with frailty in heart failure (HF) patients, focusing on demographic, biochemical and health‐related variables. It also explored the correlation between frailty and comorbidities such as malnutrition, cognitive impairment and depression, assessing how these factors interact to influence ...
Marta Wleklik   +6 more
wiley   +1 more source

Models of the cardiac L‐type calcium current: A quantitative review

open access: yesWIREs Mechanisms of Disease, Volume 15, Issue 1, January/February 2023., 2023
We discuss 73 published models of mammalian ICaL and find differences in gating kinetics, electrochemical driving force, and sensitivity to internal calcium concentrations, leading to considerable variability in their predictions. Abstract The L‐type calcium current (ICaL) plays a critical role in cardiac electrophysiology, and models of ICaL are vital
Aditi Agrawal   +7 more
wiley   +1 more source

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