Results 101 to 110 of about 186,020 (321)

Heart failure decompensation with cardiogenic shock exhibits distinct sequential inflammatory profiles

open access: yesESC Heart Failure, EarlyView.
Abstract Aims The inflammatory profile of cardiogenic shock (CS) after myocardial infarction affects outcomes; however, little is known about the impact of inflammatory changes in CS caused by acute decompensated heart failure (ADHF‐CS). We measured levels of inflammatory cytokines in patients with ADHF‐CS admitted to a cardiac intensive care unit ...
Darshan H. Brahmbhatt   +9 more
wiley   +1 more source

Fusion of the β2‐adrenergic receptor with either Gαs or βarrestin‐2 produces constitutive signaling by each pathway and induces gain‐of‐function in BEAS‐2B cells

open access: yesFASEB BioAdvances, Volume 4, Issue 12, Page 758-774, December 2022., 2022
Abstract The β2AR is a prototypical G protein‐coupled receptor (GPCR) known to orchestrate different cellular responses by the stimulation of specific signaling pathways. The best‐established signaling pathways for the β2AR are the canonical Gs pathway and the alternative β arrestin 2 (βarr2) pathway.
Emilio Y. Lucero‐Garcia Rojas   +4 more
wiley   +1 more source

Inhibition of the lipolytic action of beta-adrenergic agonists in human adipocytes by alpha-adrenergic agonists.

open access: yesJournal of Lipid Research, 1981
The aim of this study was to define the role of the alpha-adrenergic receptor in the regulation of lipolysis by human adipocytes. Glycerol production by isolated human adipocytes was stimulated by the pure beta-adrenergic agonist isoproterenol in a dose ...
E E Wright, E R Simpson
doaj  

Robust Simulation-Based Inference under Missing Data via Neural Processes [PDF]

open access: yesarXiv
Simulation-based inference (SBI) methods typically require fully observed data to infer parameters of models with intractable likelihood functions. However, datasets often contain missing values due to incomplete observations, data corruptions (common in astrophysics), or instrument limitations (e.g., in high-energy physics applications).
arxiv  

Immune cell dynamics in heart failure: implicated mechanisms and therapeutic targets

open access: yesESC Heart Failure, EarlyView.
Abstract The relationship between heart failure (HF) and immune activation has garnered significant interest. Studies highlight the critical role of inflammation in HF, affecting cardiac structure and function. Despite promising anti‐inflammatory therapies, clinical trials have faced challenges, indicating an incomplete understanding of immune ...
Gen Li, Wu He, Dao Wen Wang
wiley   +1 more source

Pregnancy modifies the α2-β-adrenergic receptor functional balance in rabbit fat cells

open access: yesJournal of Lipid Research, 1999
The sympathetic nervous system controls lipolysis in fat by activation of four adrenergic receptors: β1, β2, β3, and α2. During pregnancy, maternal metabolism presents anabolic and catabolic phases, characterized by modifications of fat responsiveness to
Alain Bousquet-Mélou   +4 more
doaj  

The renal vasodilatation from β‐adrenergic activation in vivo in rats is not driven by KV7 and BKCa channels

open access: yesExperimental Physiology
The mechanisms behind renal vasodilatation elicited by stimulation of β‐adrenergic receptors are not clarified. As several classes of K channels are potentially activated, we tested the hypothesis that KV7 and BKCa channels contribute to the decreased ...
Charlotte Mehlin Sorensen   +3 more
doaj   +1 more source

Effects of exercise modalities on physical function and quality of life in patients with heart failure: A systematic review and network meta‐analysis

open access: yesESC Heart Failure, EarlyView.
Abstract Aims This study aimed to evaluate the effects of various exercise modalities on physical function and quality of life in individuals with heart failure and to identify the most effective approaches. Methods and results A network meta‐analysis was conducted by searching PubMed, Embase and the Cochrane Library databases.
Jiang‐Ying Li   +5 more
wiley   +1 more source

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