Results 21 to 30 of about 307,039 (247)

Design and Implementation of Computeraided Learning Module in Pharmacology for Vasoactive Drugs: An Experience from a State Medical College in Haryana, India [PDF]

Journal of Clinical and Diagnostic Research
Introduction: In the Competency-based Medical Education (CBME) curriculum, one of the core competencies involves demonstrating the effects of autonomic drugs.
Jayant Kumar Kairi, Nitika Sharma
doaj   +1 more source

Co-Evolution of Opioid and Adrenergic Ligands and Receptors: Shared, Complementary Modules Explain Evolution of Functional Interactions and Suggest Novel Engineering Possibilities

Life, 2021
Cross-talk between opioid and adrenergic receptors is well-characterized and involves second messenger systems, the formation of receptor heterodimers, and the presence of extracellular allosteric binding regions for the complementary ligand; however ...
Robert Root-Bernstein, Beth Churchill
doaj   +1 more source

Selectivity and Maximum Response of Vibegron and Mirabegron for β3-Adrenergic Receptors

Current Therapeutic Research, 2022
: Background: The β3-adrenergic agonists vibegron and mirabegron have shown favorable safety profiles and efficacy for the treatment of overactive bladder.
Benjamin M. Brucker, MD, Jennifer King, PharmD, Paul N. Mudd, Jr, PharmD, MBA, Kimberly McHale, PhD   +3 more
doaj   +1 more source

β-Adrenergic Blockers [PDF]

The Journal of Clinical Hypertension, 2011
KEY POINTS AND PRACTICAL RECOMMENDATIONS: •  β-Blockers are appropriate treatment for patients with hypertension and those who have concomitant ischemic heart disease, heart failure, obstructive cardiomyopathy, or certain arrhythmias. •  β-Blockers can be used in combination with other antihypertensive drugs to achieve maximal blood pressure control ...
Elijah Saunders, William H. Frishman
openaire   +3 more sources

New Insights in Cardiac β-Adrenergic Signaling During Heart Failure and Aging

Frontiers in Pharmacology, 2018
Heart failure (HF) has become increasingly common within the elderly population, decreasing their survival and overall quality of life. In fact, despite the improvements in treatment, many elderly people suffer from cardiac dysfunction (HF, valvular ...
Claudio de Lucia, A. Eguchi, W. Koch
semanticscholar   +1 more source

Adrenergic Signaling: A Targetable Checkpoint Limiting Development of the Antitumor Immune Response

Frontiers in Immunology, 2018
An immune response must be tightly controlled so that it will be commensurate with the level of response needed to protect the organism without damaging normal tissue. The roles of cytokines and chemokines in orchestrating these processes are well known,
Guanxi Qiao, Minhui Chen, Mark J. Bucsek, Elizabeth A. Repasky, Bonnie L. Hylander   +4 more
doaj   +1 more source

Investigation of the Adrenergic and Opioid Binding affinities, Metabolic Stability, Plasma Protein Binding Properties and Functional Effects of Selected Indole-based Kratom Alkaloids.

Journal of Medicinal Chemistry, 2019
Selected indole-based kratom alkaloids were evaluated for their opioid and adrenergic receptor binding and functional effects, in vivo antinociceptive effects, plasma protein binding and metabolic stability.
Samuel Obeng, Shyam H Kamble, Morgan E. Reeves, Luis F. Restrepo, Avi Patel, M. Behnke, Nelson Jeng Yeou Chear, S. Ramanathan, Abhisheak Sharma, F. León, T. Hiranita, B. Avery, L. McMahon, C. McCurdy   +13 more
semanticscholar   +1 more source

Postnatal - Physiological Research of the Bronchial Receptor System Development on the Isolated Preparation of The Human Trachea In Vitro

Biomolecules & Biomedicine, 2006
Research was done on pharmacological-physiological development of the bronchial receptor system on the smooth muscles of trachea in the newborn children, alive-born and stillborn children.
Aziz Šukalo, Hilmi Islami, Ragib Shabani, Hilmi Dauti, Skender Kutllovci, Bashkim Kastrati   +5 more
doaj   +1 more source

FRET biosensor uncovers cAMP nano-domains at β-adrenergic targets that dictate precise tuning of cardiac contractility

Nature Communications, 2017
Compartmentalized cAMP/PKA signalling is now recognized as important for physiology and pathophysiology, yet a detailed understanding of the properties, regulation and function of local cAMP/PKA signals is lacking.
N. Surdo, M. Berrera, A. Koschinski, Marcella Brescia, M. Machado, C. Carr, P. Wright, J. Gorelik, S. Morotti, E. Grandi, D. Bers, S. Pantano, M. Zaccolo   +12 more
semanticscholar   +1 more source

Single Cell Sequencing of the Pineal Gland: The Next Chapter

Frontiers in Endocrinology, 2019
The analysis of pineal cell biology has undergone remarkable development as techniques have become available which allow for sequencing of entire transcriptomes and, most recently, the sequencing of the transcriptome of individual cells.
Steven L. Coon, Cong Fu, Cong Fu, Steven W. Hartley, Lynne Holtzclaw, Joseph C. Mays, Michael C. Kelly, Matthew W. Kelley, James C. Mullikin, Martin F. Rath, Luis E. Savastano, David C. Klein   +11 more
doaj   +1 more source