Results 21 to 30 of about 468,250 (391)

Effects of caerulein on the gastric motility of rats. [PDF]

, 1985
The effects of caerulein on gastric motility in urethane-anesthetized rats were studied. Caerulein administered into the lateral cerebral ventricle (i.c.v.) and jugular vein (i.v.) caused predominantly an inhibitory effect on gastric motility but ...
Jin, Ze-Zhong, Nakayama, Sosogu, Neya, Toshiaki   +2 more
core   +1 more source

Mechanism of adrenergic CaV1.2 stimulation revealed by proximity proteomics

Nature, 2019
Increased cardiac contractility during the fight-or-flight response is caused by β-adrenergic augmentation of CaV1.2 voltage-gated calcium channels1–4.
Guoxia Liu, Arianne Papa, A. Katchman, S. Zakharov, Daniel Roybal, Jessica A Hennessey, Jared S. Kushner, Lin Yang, Bi-xing Chen, Alexander Kushnir, K. Dangas, S. Gygi, G. Pitt, H. Colecraft, Manu Ben-Johny, Marian Kalocsay, S. Marx   +16 more
semanticscholar   +1 more source

Postnatal - Physiological Research of the Bronchial Receptor System Development on the Isolated Preparation of The Human Trachea In Vitro

Biomolecules & Biomedicine, 2006
Research was done on pharmacological-physiological development of the bronchial receptor system on the smooth muscles of trachea in the newborn children, alive-born and stillborn children.
Aziz Šukalo, Hilmi Islami, Ragib Shabani, Hilmi Dauti, Skender Kutllovci, Bashkim Kastrati   +5 more
doaj   +1 more source

Co-Evolution of Opioid and Adrenergic Ligands and Receptors: Shared, Complementary Modules Explain Evolution of Functional Interactions and Suggest Novel Engineering Possibilities

Life, 2021
Cross-talk between opioid and adrenergic receptors is well-characterized and involves second messenger systems, the formation of receptor heterodimers, and the presence of extracellular allosteric binding regions for the complementary ligand; however ...
Robert Root-Bernstein, Beth Churchill
doaj   +1 more source

Postsynaptic α1-Adrenergic vasoconstriction is impaired in young patients with vasovagal syncope and is corrected by nitric oxide synthase inhibition [PDF]

, 2016
BACKGROUND: Syncope is a sudden transient loss of consciousness and postural tone with spontaneous recovery; the most common form is vasovagal syncope (VVS).
Medow, MS, Merchant, S, Stewart, JM, Suggs, M, Sutton, R, Terilli, C, Visintainer, P   +6 more
core   +1 more source

Pharmacogenetics of ophthalmic topical β-blockers [PDF]

, 2008
Glaucoma is the second leading cause of blindness worldwide. The primary glaucoma risk factor is elevated intraocular pressure. Topical β-blockers are affordable and widely used to lower intraocular pressure.
McCarty, Catherine A., Patchett, Richard, Sidjanin, Duska J., Smith, Edward M., Wilke, Russell A.   +4 more
core   +1 more source

Single Cell Sequencing of the Pineal Gland: The Next Chapter

Frontiers in Endocrinology, 2019
The analysis of pineal cell biology has undergone remarkable development as techniques have become available which allow for sequencing of entire transcriptomes and, most recently, the sequencing of the transcriptome of individual cells.
Steven L. Coon, Cong Fu, Cong Fu, Steven W. Hartley, Lynne Holtzclaw, Joseph C. Mays, Michael C. Kelly, Matthew W. Kelley, James C. Mullikin, Martin F. Rath, Luis E. Savastano, David C. Klein   +11 more
doaj   +1 more source

Selectivity and Maximum Response of Vibegron and Mirabegron for β3-Adrenergic Receptors

Current Therapeutic Research, 2022
: Background: The β3-adrenergic agonists vibegron and mirabegron have shown favorable safety profiles and efficacy for the treatment of overactive bladder.
Benjamin M. Brucker, MD, Jennifer King, PharmD, Paul N. Mudd, Jr, PharmD, MBA, Kimberly McHale, PhD   +3 more
doaj   +1 more source

Synthesis, Docking Study and β-Adrenoceptor Activity of Some New Oxime Ether Derivatives

Molecules, 2014
A new series of oxime ethers 4a–z was designed and synthesized to test the blocking activity against β1 and β2-adrenergic receptors. Docking of these ether derivatives into the active site of the identified 3D structures of β1 and β2-adrenergic receptors
Hazem A. Ghabbour, Eman R. El-Bendary, Mahmoud B. El-Ashmawy, Mohamed M. El-Kerdawy   +3 more
doaj   +1 more source

Cardiac hypertrophy is inhibited by a local pool of cAMP regulated by phosphodiesterase 2 [PDF]

, 2015
Rationale: Chronic elevation of 3'-5'-cyclic adenosine monophosphate (cAMP) levels has been associated with cardiac remodelling and cardiac hypertrophy.
Aronsen, Jan M., Baillie, George S., Corsetti, Veronica, Dodoni, Giuliano, Fields, Laura A., Furlan, Leonardo, Gesellchen, Frank, Graham, Delyth, Hamilton, Graham M., Jiang, He, Krall, Judith, Lefkimmiatis, Konstantinos, Livie, Craig, Mancuso, Luisa, Movsesian, Matthew, Nicklin, Stuart A., Sin, Yuan Yan, Sjaastad, Ivar, Stangherlin, Alessandra, Surdo, Nicoletta C., Szabo-Fresnais, Nicolas, Terrin, Anna, Vandeput, Fabrice, Zaccolo, Manuela, Zoccarato, Anna   +24 more
core   +1 more source