Results 21 to 30 of about 444,528 (410)

Impairment of β-adrenergic regulation and exacerbation of pressure-induced heart failure in mice with mutations in phosphoregulatory sites in the cardiac CaV1.2 calcium channel

Frontiers in Physiology, 2023
The cardiac calcium channel CaV1.2 conducts L-type calcium currents that initiate excitation-contraction coupling and serves as a crucial mediator of β-adrenergic regulation of the heart.
Liam Hovey, Liam Hovey, Xiaoyun Guo, Yi Chen, Qinghang Liu, William A. Catterall   +5 more
doaj   +1 more source

Growth hormone stimulates lipolysis in mice but not in adipose tissue or adipocyte culture

Frontiers in Endocrinology, 2023
The inhibitory effect of growth hormone (GH) on adipose tissue growth and the stimulatory effect of GH on lipolysis are well known, but the mechanisms underlying these effects are not completely understood.
Lidan Zhao, Honglin Jiang
doaj   +1 more source

Neural regulation of ILC2s in allergic airway inflammation

Frontiers in Allergy, 2023
The sympathetic nervous system (SNS) and parasympathetic nervous system (PNS) regulate the effector functions of group 2 innate lymphoid cells (ILC2s) through β2 adrenergic receptor (ADRB2) and nicotinic/muscarinic cholinergic receptor signaling ...
Christopher M. Thomas, R. Stokes Peebles, R. Stokes Peebles, R. Stokes Peebles   +3 more
doaj   +1 more source

Adrenergic regulation of immune cell function and inflammation

Seminars in Immunopathology, 2020
The sympathetic nervous system integrates the functions of multiple organ systems by regulating their autonomic physiological activities. The immune system is regulated both locally and systemically by the neurotransmitters epinephrine and norepinephrine
D. Sharma, J. D. Farrar
semanticscholar   +1 more source

Alpha-1 adrenergic receptor antagonists to prevent hyperinflammation and death from lower respiratory tract infection [PDF]

Elife 10 (2021): e61700, 2020
In severe viral pneumonia, including Coronavirus disease 2019 (COVID-19), the viral replication phase is often followed by hyperinflammation, which can lead to acute respiratory distress syndrome, multi-organ failure, and death. We previously demonstrated that alpha-1 adrenergic receptor ($\alpha_1$-AR) antagonists can prevent hyperinflammation and ...
arxiv   +1 more source

High-fat diet induces protein kinase A and G-protein receptor kinase phosphorylation of β2 -adrenergic receptor and impairs cardiac adrenergic reserve in animal hearts. [PDF]

, 2017
Key pointsPatients with diabetes show a blunted cardiac inotropic response to β-adrenergic stimulation despite normal cardiac contractile reserve. Acute insulin stimulation impairs β-adrenergically induced contractile function in isolated cardiomyocytes ...
Chiamvimonvat, Nipavan, Fu, Qin, Hu, Yuting, Kim, Sungjin, Li, Ning, Liu, Yongming, Wang, Qingtong, Xiang, Yang K, Xu, Bing   +8 more
core   +2 more sources

Genetically Encoded Biosensors Reveal PKA Hyperphosphorylation on the Myofilaments in Rabbit Heart Failure [PDF]

, 2016
RATIONALE: In heart failure, myofilament proteins display abnormal phosphorylation, which contributes to contractile dysfunction. The mechanisms underlying the dysregulation of protein phosphorylation on myofilaments is not clear.
Barbagallo, Federica, Bers, Donald, Bossuyt, Julie, Ferrier, William, Fu, Qin, Ginsburg, Kenneth S., Isidori, Andrea, Li, Minghui, Naro, Fabio, Patel, Hemal H., Reddy, Gopireddy R., Shi, Qian, Wang, Qingtong, West, Toni, Xiang, Yang K., Xu, Bing   +15 more
core   +1 more source

Beta-Adrenergic Agonists [PDF]

Pharmaceuticals, 2010
Inhaled β2-adrenoceptor (β2-AR) agonists are considered essential bronchodilator drugs in the treatment of bronchial asthma, both as symptoms-relievers and, in combination with inhaled corticosteroids, as disease-controllers. In this article, we first review the basic mechanisms by which the β2-adrenergic system contributes to the control of airway ...
Giovanni Barisione, BAROFFIO, MICHELE, CRIMI, EMANUELE, BRUSASCO, VITO   +3 more
openaire   +3 more sources

Mechanism of adrenergic CaV1.2 stimulation revealed by proximity proteomics

Nature, 2019
Increased cardiac contractility during the fight-or-flight response is caused by β-adrenergic augmentation of CaV1.2 voltage-gated calcium channels1–4.
Guoxia Liu, Arianne Papa, A. Katchman, S. Zakharov, Daniel Roybal, Jessica A Hennessey, Jared S. Kushner, Lin Yang, Bi-xing Chen, Alexander Kushnir, K. Dangas, S. Gygi, G. Pitt, H. Colecraft, Manu Ben-Johny, M. Kalocsay, S. Marx   +16 more
semanticscholar   +1 more source

Adrenergic Myocarditis in Pheochromocytoma [PDF]

Journal of Cardiovascular Magnetic Resonance, 2011
The clinical presentation of pheochromocytoma is variable and many biochemical and imaging methods have been suggested to improve the diagnostic accuracy of what has been termed "the great masquerader". This case-report is of a middle-aged woman with a non-specific clinical presentation suggesting acute coronary syndrome or subacute myocarditis ...
Roghi, A, Petrotti, P, Millazzo, A, Bonacina, E, Bucciarelli-Ducci, C   +4 more
openaire   +5 more sources