Single Cell Sequencing of the Pineal Gland: The Next Chapter
Frontiers in Endocrinology, 2019 The analysis of pineal cell biology has undergone remarkable development as techniques have become available which allow for sequencing of entire transcriptomes and, most recently, the sequencing of the transcriptome of individual cells.
Steven L. Coon +11 more
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Differential expression of skeletal muscle genes following administration of clenbuterol to exercised horses. [PDF]
, 2016 BackgroundClenbuterol, a beta2-adrenergic receptor agonist, is used therapeutically to treat respiratory conditions in the horse. However, by virtue of its mechanism of action it has been suggested that clenbuterol may also have repartitioning affects in
Chouicha, Nadira +4 more
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Synthesis, Docking Study and β-Adrenoceptor Activity of Some New Oxime Ether Derivatives
Molecules, 2014 A new series of oxime ethers 4a–z was designed and synthesized to test the blocking activity against β1 and β2-adrenergic receptors. Docking of these ether derivatives into the active site of the identified 3D structures of β1 and β2-adrenergic receptors
Hazem A. Ghabbour +3 more
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Selectivity and Maximum Response of Vibegron and Mirabegron for β3-Adrenergic Receptors
Current Therapeutic Research, 2022 : Background: The β3-adrenergic agonists vibegron and mirabegron have shown favorable safety profiles and efficacy for the treatment of overactive bladder.
Benjamin M. Brucker, MD +3 more
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Blockade of alpha 2-adrenergic receptors in prelimbic cortex: impact on cocaine self-administration in adult spontaneously hypertensive rats following adolescent atomoxetine treatment [PDF]
, 2017 RATIONALE: Research with the spontaneously hypertensive rat (SHR) model of attention deficit/hyperactivity disorder demonstrated that chronic methylphenidate treatment during adolescence increased cocaine self-administration established during adulthood ...
Baskin, Britahny M. +3 more
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Single prazosin infusion in prelimbic cortex Fosters extinction of amphetamine-induced conditioned place preference [PDF]
, 2017 Exposure to drug-associated cues to induce extinction is a useful strategy to contrast cue-induced drug seeking. Norepinephrine (NE) transmission in medial prefrontal cortex has a role in the acquisition and extinction of conditioned place preference ...
Alessandro Rava +8 more
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The heartbreak of depression: 'Psycho-cardiac' coupling in myocardial infarction [PDF]
, 2017 Ample evidence identifies strong links between major depressive disorder (MDD) and both risk of ischemic or coronary heart disease (CHD) and resultant morbidity and mortality. The molecular mechanistic bases of these linkages are poorly defined. Systemic
Budiono, Boris P +5 more
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Pharmacogenetics of ophthalmic topical β-blockers [PDF]
, 2008 Glaucoma is the second leading cause of blindness worldwide. The primary glaucoma risk factor is elevated intraocular pressure. Topical β-blockers are affordable and widely used to lower intraocular pressure.
McCarty, Catherine A. +4 more
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Personality effects on cardiovascular reactivity: need for closure moderates the impact of task difficulty on engagement-related myocardial beta-adrenergic activity [PDF]
, 2012 An experiment assessed the joint effect of dispositional need for closure (NFC) and task difficulty on engagement-related myocardial beta-adrenergic activity.
Baeriswyl, Eric +2 more
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Effect of Nebulisation with Dexmedetomidine versus Magnesium Sulphate on Haemodynamic Response to Laryngoscopy and Intubation and Incidence of Postoperative Sore Throat: A Randomised Clinical Trial [PDF]
Journal of Clinical and Diagnostic ResearchIntroduction: Laryngoscopy and endotracheal intubation are essential procedures in general anaesthesia but can induce sympathetic hyperactivity, leading to transient increase in blood pressure and Heart Rate (HR).
Fateh Pal Singh Gill, Chhaya Suryawanshi
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