Field‐applicable low‐intensity exercise induces bronchodilation in horses with severe asthma
Abstract Background Airway dysfunction in severe equine asthma (SEA) often results in early retirement or euthanasia of affected horses. Exercise‐induced bronchodilation occurs in horses with SEA after intense treadmill exercise, but the effects of a lighter, field‐applicable, training regimen remain largely unexplored.
Sophie Mainguy‐Seers +2 more
wiley +1 more source
Aβ and tau clearance through aerobic exercise: unveiling the β2-adrenergic receptor's role in regulating autophagy-lysosomal pathways. [PDF]
Yang L, Yu H, Chai GS.
europepmc +1 more source
Physiological and behavioural effects of continuous remifentanil‐xylazine administration in donkeys
Abstract Background Remifentanil and xylazine are used as continuous infusions to facilitate standing surgery in horses. Their use for this purpose has not been reported in donkeys. Objectives To evaluate the behavioural, sedative, and cardiorespiratory effects of continuous intravenous infusion of remifentanil and xylazine in donkeys. Study Design Non‐
Kássia Fernanda Araújo Damasceno +6 more
wiley +1 more source
Adrenergic signaling coordinates distant and local responses to amputation in axolotl. [PDF]
Payzin-Dogru D +37 more
europepmc +1 more source
Dietary anthocyanidin pelargonidin activates G protein‐coupled receptor 35
Pelargonidin, a red‐fruit‐derived anthocyanidin, was newly identified as a dietary agonist of GPR35, a metabolite‐sensing GPCR implicated in anti‐inflammation. Through screening of dietary compounds, pelargonidin emerged as a potent GPR35 agonist, attenuating inflammation in human intestinal cells.
Fumie Nakashima +11 more
wiley +1 more source
Engineering Human 3D Cardiac Tissues for Predictive Functional Drug Screening. [PDF]
Baruch ES +5 more
europepmc +1 more source
Regulation of PHOX2B gene expression by the long non‐coding natural antisense RNA PHOX2B‐AS1
PHOX2B is a transcription factor essential for autonomic nervous system development. We identify and characterize PHOX2B‐AS1, a human long non‐coding antisense transcript at the PHOX2B locus, along with its murine counterpart. Our findings reveal bidirectional transcription and reciprocal regulation: PHOX2B activates PHOX2B‐AS1, whereas PHOX2B‐AS1 ...
Simona Di Lascio +12 more
wiley +1 more source
Venlafaxine-associated priapism: Case report and review of priapism linked to psychotropic medications. [PDF]
Kaura KS, Kumar M, Gaur AS.
europepmc +1 more source
Abstract Objective/Background This study was undertaken to assess participants' impression of use and satisfaction with STS101 in a long‐term, open‐label safety study. The ASCEND study assessed the safety and tolerability of STS101, an investigational drug–device combination of 5.2 mg dihydroergotamine in a single‐use nasal delivery device for the ...
Jessica Ailani +4 more
wiley +1 more source

