Results 31 to 40 of about 307,039 (247)

Synthesis, Docking Study and β-Adrenoceptor Activity of Some New Oxime Ether Derivatives

Molecules, 2014
A new series of oxime ethers 4a–z was designed and synthesized to test the blocking activity against β1 and β2-adrenergic receptors. Docking of these ether derivatives into the active site of the identified 3D structures of β1 and β2-adrenergic receptors
Hazem A. Ghabbour, Eman R. El-Bendary, Mahmoud B. El-Ashmawy, Mohamed M. El-Kerdawy   +3 more
doaj   +1 more source

β-adrenergic signaling networks in adipocytes for recruiting stored fat and energy expenditure

Frontiers in Endocrinology, 2012
The adipocyte is like a bank: a place to store excess (caloric) cash in times of plenty, and from which one can withdraw savings during "lean times".
Sheila eCollins
doaj   +1 more source

Adrenergic urticaria and adrenergic pruritus.

Acta Dermato-Venereologica, 1990
We report here on 2 patients with adrenergic urticaria and adrenergic pruritus, respectively. The lesions and features developed during phases of stress and during the attacks were associated with an increase in the plasma concentrations of noradrenalin, adrenalin and prolactin.
openaire   +2 more sources

Adrenergic control of the adaptive immune response by diurnal lymphocyte recirculation through lymph nodes

Journal of Experimental Medicine, 2016
Suzuki et al. show that neural inputs to β2-adrenergic receptors expressed on lymphocytes generate the diurnal variation in the frequency of lymphocyte egress from lymph nodes, which is reflected in the magnitude of the adaptive immune response.
Kazuhiro Suzuki, Yuki Hayano, Akiko Nakai, Fumika Furuta, M. Noda   +4 more
semanticscholar   +1 more source

The insertion/deletion variation in the α_2B-adrenoceptor does not seem to modify the risk for acute myocardial infarction, but may modify the risk for hypertension in sib-pairs from families with type 2 diabetes

Cardiovascular Diabetology, 2003
Background An insertion/deletion polymorphism in the α2B-adrenoceptor (AR) has been associated with the risk for acute myocardial infarction (AMI) and sudden cardiac death. In this study we tested whether this polymorphism is associated with the risk for
Orho-Melander Marju, Groop Leif C, Scheinin Mika, Snapir Amir   +3 more
doaj   +1 more source

Adrenergic regulation of innate immunity: a review

Frontiers in Pharmacology, 2015
The sympathetic nervous system has a major role in the brain-immune cross-talk, but few information exist on the sympathoadrenergic regulation of innate immune system.
Angela Scanzano, M. Cosentino
semanticscholar   +1 more source

Autoantibodies Against β1‐Adrenoceptor Exaggerated Ventricular Remodeling by Inhibiting CTRP9 Expression

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019
Background Autoantibodies against the second extracellular loop of the β1‐adrenoceptor (β1‐AA) act similarly to agonist of β1‐adrenergic receptor, which plays an important role in the pathophysiological characteristics of ventricular remodeling. Recently,
Yunhui Du, Shihan Zhang, Haicun Yu, Ye Wu, Ning Cao, Wen Wang, Wenli Xu, Yuming Li, Huirong Liu   +8 more
doaj   +1 more source

Biased, Bitopic, Opioid–Adrenergic Tethered Compounds May Improve Specificity, Lower Dosage and Enhance Agonist or Antagonist Function with Reduced Risk of Tolerance and Addiction

Pharmaceuticals, 2022
This paper proposes the design of combination opioid–adrenergic tethered compounds to enhance efficacy and specificity, lower dosage, increase duration of activity, decrease side effects, and reduce risk of developing tolerance and/or addiction ...
Robert Root-Bernstein
doaj   +1 more source

The Binding and Effects of Boron-Containing Compounds on G Protein-Coupled Receptors: A Scoping Review

Receptors
Boron-containing compounds (BCCs) have emerged as potential drugs. Their drug-like effects are mainly explained by their mechanisms of action in enzymes.
José M. Santiago-Quintana, Alina Barquet-Nieto, Bhaskar C. Das, Rafael Barrientos-López, Melvin N. Rosalez, Ruth M. Lopez-Mayorga, Marvin A. Soriano-Ursúa   +6 more
doaj   +1 more source

Adrenergic Receptors

, 2017
This chapter will review the essential properties of adrenergic receptors in the physiology of cardiac function and in the pathology of cardiovascular disease. Following a systematic overview and a classification of adrenergic receptors, we will discuss the pathophysiological role of the sympathetic nervous system in several conditions including ...
M. Ciccarelli, D. Sorriento, COSCIONI, Enrico, G. Iaccarino, G. Santulli   +4 more
openaire   +4 more sources