Results 41 to 50 of about 303,653 (355)

Adrenergic regulation of innate immunity: a review

Frontiers in Pharmacology, 2015
The sympathetic nervous system has a major role in the brain-immune cross-talk, but few information exist on the sympathoadrenergic regulation of innate immune system.
Angela Scanzano, M. Cosentino
semanticscholar   +1 more source

The anticancer effect of the HDAC inhibitor belinostat is enhanced by inhibitors of Bcl‐xL or Mcl‐1 in ovarian cancer

Molecular Oncology, EarlyView.
The pan‐HDAC inhibitor belinostat increases the expression of the pro‐apoptotic proteins Bim, Puma, and Noxa and induces apoptosis in ovarian cancer cell lines and patient‐derived tumor organoids when used at high concentrations. Moreover, inhibiting the anti‐apoptotic proteins Bcl‐xL or Mcl‐1 sensitizes these preclinical models to the cytotoxic effect
Cécilia Thomine, Sterenn Guillemot, Louis‐Bastien Weiswald, Romane Florent, Edwige Abeilard, Florence Giffard, Emilie Brotin, Mélanie Briand, Enora Dolivet, Laurent Poulain, Marie Villedieu   +10 more
wiley   +1 more source

β-adrenergic signaling networks in adipocytes for recruiting stored fat and energy expenditure

Frontiers in Endocrinology, 2012
The adipocyte is like a bank: a place to store excess (caloric) cash in times of plenty, and from which one can withdraw savings during "lean times".
Sheila eCollins
doaj   +1 more source

Bioengineering facets of the tumor microenvironment in 3D tumor models: insights into cellular, biophysical and biochemical interactions

FEBS Open Bio, EarlyView.
The tumor microenvironment is a dynamic, multifaceted complex system of interdependent cellular, biochemical, and biophysical components. Three‐dimensional in vitro models of the tumor microenvironment enable a better understanding of these interactions and their impact on cancer progression and therapeutic resistance.
Salma T. Rafik, Deniz Bakkalci, Alexander J. MacRobert, Umber Cheema   +3 more
wiley   +1 more source

Transmural Autonomic Regulation of Cardiac Contractility at the Intact Heart Level

Frontiers in Physiology, 2019
The relationship between cardiac excitability and contractility depends on when Ca2+ influx occurs during the ventricular action potential (AP). In mammals, it is accepted that Ca2+ influx through the L-type Ca2+ channels occurs during AP phase 2 ...
Yuriana Aguilar-Sanchez, Ainhoa Rodriguez de Yurre, Mariana Argenziano, Ariel L. Escobar, Josefina Ramos-Franco   +4 more
doaj   +1 more source

Co‐overexpression of the caloric restriction‐induced mitochondrial factors PGC‐1α and MIPEP upregulates Phospho1 expression in adipocytes

FEBS Open Bio, EarlyView.
Caloric restriction that extends lifespan induces the expression of PGC‐1α and MIPEP in white adipose tissue. In this study, co‐overexpression of Pgc‐1α and Mipep upregulated the gene expression of PHOSPHO1. These findings provide new insights into mitochondria‐related mechanisms underlying the effects of caloric restriction in adipocytes.
Mamiko Ishimatsu, Kanari Taki, Asuka Hayami, Komachi Kato, Yuka Nozaki, Yuhei Mizunoe, Takumi Narita, Ryoichi Mori, Yoshikazu Higami, Masaki Kobayashi   +9 more
wiley   +1 more source

Acylated and unacylated ghrelin directly regulate ß-3 stimulated lipid turnover in rodent subcutaneous and visceral adipose tissue ex vivo but not in vivo

Adipocyte, 2019
Ghrelin has garnered interest as a gut-derived regulator of lipid metabolism, beyond its classical roles in driving appetite and growth hormone release.
Daniel T. Cervone, Justin Sheremeta, Emily N. Kraft, David J. Dyck   +3 more
doaj   +1 more source

β2-adrenergic receptor knockout mice exhibit A diabetic retinopathy phenotype. [PDF]

PLoS ONE, 2013
There is considerable evidence from our lab and others for a functional link between β-adrenergic receptor and insulin receptor signaling pathways in retina.
Youde Jiang, Qiuhua Zhang, Li Liu, Jie Tang, Timothy S Kern, Jena J Steinle   +5 more
doaj   +1 more source

Neuronal ensembles sufficient for recovery sleep and the sedative actions of α2 adrenergic agonists

Nature Neuroscience, 2015
Do sedatives engage natural sleep pathways? It is usually assumed that anesthetic-induced sedation and loss of righting reflex (LORR) arise by influencing the same circuitry to lesser or greater extents.
Zhe Zhang, V. Ferretti, İlke Güntan, A. Moro, E. Steinberg, Z. Ye, A. Zecharia, Xiao Yu, A. Vyssotski, S. Brickley, R. Yustos, Zoe E Pillidge, Edward C. Harding, W. Wisden, N. Franks   +14 more
semanticscholar   +1 more source

Adrenergic Receptors

, 2017
This chapter will review the essential properties of adrenergic receptors in the physiology of cardiac function and in the pathology of cardiovascular disease. Following a systematic overview and a classification of adrenergic receptors, we will discuss the pathophysiological role of the sympathetic nervous system in several conditions including ...
M. Ciccarelli, D. Sorriento, COSCIONI, Enrico, G. Iaccarino, G. Santulli   +4 more
openaire   +4 more sources