Results 51 to 60 of about 468,250 (391)

Autoantibodies Against β1‐Adrenoceptor Exaggerated Ventricular Remodeling by Inhibiting CTRP9 Expression

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019
Background Autoantibodies against the second extracellular loop of the β1‐adrenoceptor (β1‐AA) act similarly to agonist of β1‐adrenergic receptor, which plays an important role in the pathophysiological characteristics of ventricular remodeling. Recently,
Yunhui Du, Shihan Zhang, Haicun Yu, Ye Wu, Ning Cao, Wen Wang, Wenli Xu, Yuming Li, Huirong Liu   +8 more
doaj   +1 more source

Personality effects on cardiovascular reactivity: need for closure moderates the impact of task difficulty on engagement-related myocardial beta-adrenergic activity [PDF]

, 2012
An experiment assessed the joint effect of dispositional need for closure (NFC) and task difficulty on engagement-related myocardial beta-adrenergic activity.
Baeriswyl, Eric, Richter, Michael, Roets, Arne   +2 more
core   +2 more sources

Molecular determinants of signal transduction in tropomyosin receptor kinases

FEBS Open Bio, EarlyView.
Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley   +1 more source

Transmural Autonomic Regulation of Cardiac Contractility at the Intact Heart Level

Frontiers in Physiology, 2019
The relationship between cardiac excitability and contractility depends on when Ca2+ influx occurs during the ventricular action potential (AP). In mammals, it is accepted that Ca2+ influx through the L-type Ca2+ channels occurs during AP phase 2 ...
Yuriana Aguilar-Sanchez, Ainhoa Rodriguez de Yurre, Mariana Argenziano, Ariel L. Escobar, Josefina Ramos-Franco   +4 more
doaj   +1 more source

Adrenergic control of the adaptive immune response by diurnal lymphocyte recirculation through lymph nodes

Journal of Experimental Medicine, 2016
Suzuki et al. show that neural inputs to β2-adrenergic receptors expressed on lymphocytes generate the diurnal variation in the frequency of lymphocyte egress from lymph nodes, which is reflected in the magnitude of the adaptive immune response.
Kazuhiro Suzuki, Yuki Hayano, Akiko Nakai, Fumika Furuta, M. Noda   +4 more
semanticscholar   +1 more source

Patatin‐domain‐containing (phospho)lipases under control: Mammalian co‐regulators and pathogenic activation mechanisms

FEBS Open Bio, EarlyView.
Patatin domain‐containing (phospho)lipases are lipid‐hydrolyzing enzymes central to metabolism, membrane remodeling, and signaling. Their activity relies on precise co‐activation mechanisms involving protein–protein interactions and conformational rearrangements.
Noopur Dubey, Lina Riegler‐Berket, Monika Oberer   +2 more
wiley   +1 more source

Biased, Bitopic, Opioid–Adrenergic Tethered Compounds May Improve Specificity, Lower Dosage and Enhance Agonist or Antagonist Function with Reduced Risk of Tolerance and Addiction

Pharmaceuticals, 2022
This paper proposes the design of combination opioid–adrenergic tethered compounds to enhance efficacy and specificity, lower dosage, increase duration of activity, decrease side effects, and reduce risk of developing tolerance and/or addiction ...
Robert Root-Bernstein
doaj   +1 more source

Catecholamine stress alters neutrophil trafficking and impairs wound healing by β2-adrenergic receptor-mediated upregulation of IL-6. [PDF]

, 2014
Stress-induced hormones can alter the inflammatory response to tissue injury; however, the precise mechanism by which epinephrine influences inflammatory response and wound healing is not well defined.
Byrne, Barbara A, Gorouhi, Farzam, Granick, Jennifer L, Isseroff, Rivkah R, Kim, Min-Ho, Ramirez, Sandra, Simon, Scott I, Soulika, Athena M   +7 more
core   +2 more sources

The Aging Blood: Cellular Origins, Circulating Drivers, and Therapeutic Potential

Aging and Cancer, EarlyView.
As a conduit linking all organs, the blood system both reflects and actively drives systemic aging. This review highlights how circulating pro‐aging and antiaging factors and age‐associated hematopoietic stem cell dysfunction contribute to immunosenescence and multi‐organ decline, positioning the hematopoietic system as a target for aging intervention.
Hanqing He, Jianwei Wang
wiley   +1 more source

Involvement of Noradrenergic Neurotransmission in the Stress- but not Cocaine-Induced Reinstatement of Extinguished Cocaine-Induced Conditioned Place Preference in Mice: Role for β-2 Adrenergic Receptors [PDF]

, 2010
The responsiveness of central noradrenergic systems to stressors and cocaine poses norepinephrine as a potential common mechanism through which drug re-exposure and stressful stimuli promote relapse.
A Dzung Lê, AD Le, AH Tiong, AM Snoddy, AN Fricks-Gleason, Andy Weyer, AR Davis, AS Kreibich, B Lee, B Ribeiro Do Couto, B Wang, C Drouin, C Lanteri, C Orsini, CA Jiménez-Rivera, CA Rudoy, Chad E Beyer, CJ McDougle, D Highfield, D Weinshenker, David A Baker, DJ Macey, DJ Sanger, DM Platt, ED Abercrombie, F Leri, FH Gawin, G Bricca, GC Harris, GC Harris, HD Schmidt, Holly Caretta, J Stewart, JC Winter, JM Dwyer, JM Finlay, John R Mantsch, JR Schank, KM Kampman, KM Kampman, L Cervo, L Lu, LJ Vanderschuren, M Sofuoglu, M Sofuoglu, M Sofuoglu, ME Reith, MH Baumann, MJ Millan, MK Horne, MS Kleven, MW Feltenstein, MY Li, OA Tjurmina, Oliver Vranjkovic, PJ Fletcher, R Sinha, R Sinha, R Sinha, RD Spealman, RE Bernardi, RE Bernardi, RJ Smith, RM Eglen, S Deyama, S Erb, S Erb, S Erb, S Wee, SM Florin, T Belej, T Tanaka, T Watanabe, TC Rainbow, TJ Beveridge, TM Tzschentke, VA Redila, WL Woolverton, X Wang, XY Zhang, XY Zhang, Y Itzhak, Y Shaham, Y Shaham, Y Shaham, Y Shaham, ZJ Brown   +86 more
core   +3 more sources