Results 81 to 90 of about 186,020 (321)
Serotonergic modulators in Alzheimer's disease: a hope in the hopeless condition
Chemistry &Biodiversity, Accepted Article.Alzheimer disease (AD) is the main cause of dementia worldwide. AD is a progressive brain neurodegenerative disease due to genetic and environmental factors that induce a progressive accumulation of intracellular hyperphosphorylated tau protein and extracellular amyloid protein (Aβ).
Ali I. Al-Gareeb +5 more
wiley +1 more source
Inhibition of signaling downstream of beta‐2 adrenoceptor by propranolol in prostate cancer cells
The Prostate, Volume 83, Issue 3, Page 237-245, February 15, 2023., 2023 Abstract Background There is accumulating evidence that propranolol, an antagonist of beta‐1 and beta‐2 adrenoreceptors, extends survival of patients with prostate cancer; yet it is not known whether propranolol inhibits beta‐adrenergic signaling in prostate cancer cells, or systemic effects of propranolol play the leading role in slowing down cancer ...
Aljoharah Alaskar +7 more
wiley +1 more source
ß-Adrenergic stimulation increases RyR2 activity via intracellular Ca2+ and Mg2+ regulation.
PLoS ONE, 2013 Here we investigate how ß-adrenergic stimulation of the heart alters regulation of ryanodine receptors (RyRs) by intracellular Ca(2+) and Mg(2+) and the role of these changes in SR Ca(2+) release.
Jiao Li +6 more
doaj +1 more source
Beta-Adrenergic Blockers [PDF]
Circulation, 2003 beta-Adrenergic blocking drugs have been available for several years to treat ischemic heart disease and other cardiovascular and noncardiovascular disorders. There are multiple drugs in this class with various pharmacodynamic and pharmacokinetic properties that may be important in specific clinical situations and in avoiding certain adverse reactions.
openaire +3 more sources
Drug Testing and Analysis, EarlyView.The metabolism of 3‐chloromethcathinone (3‐CMC) was studied after controlled administration in a murine model using the dried blood spot (DBS) technique for the sampling, storage and purification of blood samples. The metabolite profile of 3‐CMC was studied by LC‐HRMS, while the stability of 3‐CMC and its three identified metabolites was also assessed ...
Serena Mestria +6 more
wiley +1 more source
Scientific Reports, 2017 Norepinephrine modulates synaptic plasticity in various brain regions and is implicated in memory formation, consolidation and retrieval. The cerebellum is involved in motor learning, and adaptations of the vestibulo-ocular reflex (VOR) and optokinetic ...
Ryo Wakita +5 more
doaj +1 more source
Arquivos Brasileiros de Cardiologia, 2018 Background: Prenatal stress may increase risk of developing cardiovascular disorders in adulthood. The cardiotoxic effects of catecholamines are mediated via prolonged adrenergic receptor stimulation and increased oxidative stress upon their degradation ...
Tanja Jevjdovic +6 more
doaj +1 more source
EVALUATION OF THERAPEUTIC SUBSTANCES EMPLOYED FOR THE RELIEF OF BRONCHOSPASM. V. ADRENERGIC AGENTS 1 [PDF]
, 1949 Elliott Bresnick +3 more
openalex +1 more source
Drug Testing and Analysis, EarlyView.Oral administration of salbutamol shows enantioselective disposition in human skeletal muscle, favoring the (S)‐enantiomer with higher relative partitioning of the pharmacologically active (R)‐enantiomer in muscle. This is concerning from an anti‐doping point of view because the anabolic properties demonstrated for salbutamol can potentially be ...
Morten Hostrup +5 more
wiley +1 more source