Results 1 to 10 of about 23,981 (116)

Beta 2-adrenergic pathway combats Alzheimer’s disease: Restoring cognition and synaptic integrity [PDF]

Neural Regeneration Research
Alzheimer’s disease is typified by amyloid-beta oligomer-mediated synaptic disruption, neuroinflammation, and mitochondrial loss of function, culminating in cognitive decline.
Shaomin Li, Shan-Xue Jin
doaj   +2 more sources

Receptor-mediated enhancement of beta adrenergic drug activity by ascorbate in vitro and in vivo. [PDF]

PLoS ONE, 2010
RATIONALE: Previous in vitro research demonstrated that ascorbate enhances potency and duration of activity of agonists binding to alpha 1 adrenergic and histamine receptors.
Patrick F Dillon, Robert Root-Bernstein, N Edward Robinson, William M Abraham, Catherine Berney   +4 more
doaj   +1 more source

Evaluation of short-acting Beta-2-agonist prescriptions and associated clinical outcomes: Findings from the SABA use IN Asthma (SABINA) study in Asia

World Allergy Organization Journal, 2023
Background: The extent of short-acting Beta-2-agonist (β2-agonist) (SABA) use across Asian countries is not well documented. As part of the SABA use IN Asthma (SABINA) III study, we assessed SABA prescriptions and clinical outcomes in patients with ...
Hao-Chien Wang, MD PhD, Susanthy Djajalaksana, MD, Latha Sharma, MD, Theerakorn Theerakittikul, MD, Hui Fang Lim, MBBS, Kwang Ha Yoo, MD, Andrea Ban Yu-Lin, MMED, Dina V. Diaz, MD, Lala Yang, Master, Maarten J.H.I. Beekman, MD   +9 more
doaj   +1 more source

Beta-2 adrenergic receptor agonism alters astrocyte phagocytic activity and has potential applications to psychiatric disease

Discover Mental Health, 2023
Schizophrenia is a debilitating condition necessitating more efficacious therapies. Previous studies suggested that schizophrenia development is associated with aberrant synaptic pruning by glial cells.
Ellen R. Bowen, Phillip DiGiacomo, Hannah P. Fraser, Kevin Guttenplan, Benjamin A. H. Smith, Marlene L. Heberling, Laura Vidano, Nigam Shah, Mehrdad Shamloo, Jennifer L. Wilson, Kevin V. Grimes   +10 more
doaj   +1 more source

Inhibition of the lipolytic action of beta-adrenergic agonists in human adipocytes by alpha-adrenergic agonists.

Journal of Lipid Research, 1981
The aim of this study was to define the role of the alpha-adrenergic receptor in the regulation of lipolysis by human adipocytes. Glycerol production by isolated human adipocytes was stimulated by the pure beta-adrenergic agonist isoproterenol in a dose ...
E E Wright, E R Simpson
doaj   +1 more source

Cardiomyocyte contractile dysfunction in the APPswe/PS1dE9 mouse model of Alzheimer's disease. [PDF]

PLoS ONE, 2009
Ample clinical and experimental evidence indicated that patients with Alzheimer's disease display a high incidence of cardiovascular events. This study was designed to examine myocardial histology, cardiomyocyte shortening, intracellular Ca(2 ...
Subat Turdi, Rui Guo, Anna F Huff, Eliza M Wolf, Bruce Culver, Jun Ren   +5 more
doaj   +1 more source

The (--)[3H]dihydroalprenolol binding to rat adipocyte membranes: an explanation of curvilinear Scatchard plots and implications for quantitation of beta-adrenergic sites

Journal of Lipid Research, 1982
In rat adipocyte membranes, both beta-adrenergic agonists and beta-adrenergic antagonists competed with (--)[3H]dihydroalprenolol for high affinity (KD 2-4 nM) and low capacity binding sites.
E M Dax, J S Partilla, R I Gregerman
doaj   +1 more source

In Vitro Effects of Beta-2 Agonists on Skeletal Muscle Differentiation, Hypertrophy, and Atrophy

World Allergy Organization Journal, 2012
Background Beta-2 agonists are widely used in the treatment of asthma and chronic obstructive pulmonary disease for their effect on airway smooth muscle relaxation.
Francesca Wannenes, PhD, Loretta Magni, PhD, Matteo Bonini, MD, PhD, Ivan Dimauro, PhD, Daniela Caporossi, PhD, Costanzo Moretti, MD, Sergio Bonini, MD   +6 more
doaj   +1 more source

ASM-024, a piperazinium compound, promotes the in vitro relaxation of β2-adrenoreceptor desensitized tracheas. [PDF]

PLoS ONE, 2015
Inhaled β2-adrenoreceptor agonists are widely used in asthma and chronic obstructive pulmonary disease (COPD) for bronchoconstriction relief. β2-Adrenoreceptor agonists relax airway smooth muscle cells via cyclic adenosine monophosphate (cAMP) mediated ...
Evelyne Israël-Assayag, Marie-Josée Beaulieu, Yvon Cormier   +2 more
doaj   +1 more source

Avaliação da eficácia e segurança da associação de budesonida e formoterol em dose fixa e cápsula única no tratamento de asma não controlada: ensaio clínico randomizado, duplo-cego, multicêntrico e controlado Evaluation of the efficacy and safety of a fixed-dose, single-capsule budesonide-formoterol combination in uncontrolled asthma: a randomized, double-blind, multicenter, controlled clinical trial

Jornal Brasileiro de Pneumologia, 2012
OBJETIVO: Avaliar a eficácia e a segurança da associação de budesonida e formoterol em dose fixa e cápsula única, em comparação ao uso de budesonida isolada em pacientes com asma não controlada.
Roberto Stirbulov, Carlos Cezar Fritscher, Emilio Pizzichini, Márcia Margaret Menezes Pizzichini   +3 more
doaj   +1 more source