Results 41 to 50 of about 25,964,170 (220)

Ex Vivo Pulmonary Oedema after In Vivo Blast-Induced Rat Lung Injury: Time Dependency, Blast Intensity and Beta-2 Adrenergic Receptor Role

Biomedicines, 2022
Objective: Current treatments for blast-induced lung injury are limited to supportive procedures including mechanical ventilation. The study aimed to investigate the role of post-trauma-induced oedema generation in the function of time and trauma ...
Hanno Huwer, Yalda Hadizamani, Ueli Moehrlen, Uz Stammberger, Florian Gebhard, Lia Bally, Albrecht Wendel, Ulrich C. Liener, Rudolf Lucas, Jürg Hamacher   +9 more
doaj   +1 more source

Targeting β2‐Adrenergic Receptor Stability With Lycorine Reveals a Host‐Directed Pathway for Antiviral Defense Against Poxviruses

Advanced Science, EarlyView.
Chronic stress drives autophagy‐mediated β2‐AR degradation, impairing antiviral immunity and promoting poxvirus lethality. Lycorine directly stabilizes β2‐AR to restore host defense, suppress excessive inflammation and improve survival. ABSTRACT Psychological stress is a pervasive yet poorly understood modulator of infectious disease outcomes. Here, we
Xin Zhang, Shuqin Xu, Zixuan Zhang, Chenwen Wan, Xiaoqin Wang, Peihua Wang, Huini Yang, Tianxiao Huang, Yijia Yuan, Faiza Atique, Rui Yang, Yingli He, Zhijun Liu   +12 more
wiley   +1 more source

In Silico Multitarget Profiling of Non-Selective Beta-Blockers Highlights Their Potential as Key Agents in Breast Cancer Adjuvant Therapy via ADRB2, ERBB2, and NPYR Receptors

Current Issues in Molecular Biology
Breast cancer (BC) is associated with multiple molecular factors such as overexpression of the beta-2 adrenergic receptor (ADRB2) and the overproduction of its agonists (norepinephrine and epinephrine).
Felipe Muñoz-González, José Correa-Basurto, Iván Ignacio-Mejia, Cindy Bandala   +3 more
doaj   +1 more source

β2-Adrenoceptor Agonists in Asthma or Chronic Obstructive Pulmonary Disease and Risk of Parkinson’s Disease: Nested Case-Control Study

Clinical Epidemiology, 2023
Anne Paakinaho,1 Miia Tiihonen,1 Heikki Koskela,2,3 Marjaana Koponen,1,4 Jari Tiihonen,5,6 Sirpa Hartikainen,1 Anna-Maija Tolppanen1 1School of Pharmacy, Faculty of Health Sciences, University of Eastern Finland, Kuopio, Finland; 2Unit for Medicine and ...
Paakinaho A, Tiihonen M, Koskela H, Koponen M, Tiihonen J, Hartikainen S, Tolppanen AM   +6 more
doaj  

Common ADRB2 haplotypes derived from 26 polymorphic sites direct beta2-adrenergic receptor expression and regulation phenotypes. [PDF]

PLoS ONE, 2010
The beta2-adrenergic receptor (beta2AR) is expressed on numerous cell-types including airway smooth muscle cells and cardiomyocytes. Drugs (agonists or antagonists) acting at these receptors for treatment of asthma, chronic obstructive pulmonary disease,
Alfredo Panebra, Wayne C Wang, Molly M Malone, Demar R G Pitter, Scott T Weiss, Gregory A Hawkins, Stephen B Liggett   +6 more
doaj   +1 more source

Mitochondria‐Targeted Nanotherapeutics: A Promising Strategy in Modulating Mitochondrial Function, Transfer, and Transplantation

Advanced Science, EarlyView.
This review summarizes the pathogenic role of mitochondria in diseases and highlights mitochondrial transfer and transplantation as emerging therapeutic strategies. It systematically discusses how nanomaterials are engineered to facilitate these processes, and critically examines the current challenges and future perspectives for their clinical ...
Yuanyuan Su, Zhiyan Gong, Jiao Mu, Lili Huang, Pengfei Yang, Chenli Zhang, Lingshan Zhao, Liling Yang, Jun Deng, Xiaohui Liao   +9 more
wiley   +1 more source

The Effect of a Reduced-Calorie Diet on alpha-2 Adrenergic Receptor Responsiveness in Abdominal Adipose Tissue in Obese Men During Exercise [PDF]

, 2008
There is at present an imperfect understanding of the effect of diet on availability of inhibitory receptors in fat cells during exercise among obese men. *Objective:* The purpose of this study was to determine whether diet results in
Roy R. Estrada, Joseph O. Schmelz, David Turbow, Edith Neumann   +3 more
core  

Perspectives of drug treatment of obesity [PDF]

Einstein (São Paulo), 2006
The perspectives in the pharmacological treatment of obesitycan be classified in two classes: drugs already in the market,in advanced clinical trial or in final approval, or drugs in earlydevelopment.
Alfredo Halpern, Marcio C. Mancini
doaj  

The autonomic nervous system in septic shock and its role as a future therapeutic target: a narrative review

Annals of Intensive Care, 2021
The autonomic nervous system (ANS) regulates the cardiovascular system. A growing body of experimental and clinical evidence confirms significant dysfunction of this regulation during sepsis and septic shock.
Marta Carrara, Manuela Ferrario, Bernardo Bollen Pinto, Antoine Herpain   +3 more
doaj   +1 more source

Psychological Stress Promotes Tumor Growth in Hepatocellular Carcinoma Models Through Myeloid Signaling. [PDF]

Cancer Sci
Psychological stress promotes hepatocellular carcinoma progression through coordinated regulation of macrophages and neutrophils. Noradrenaline activates ADRB2 signaling in intratumoral macrophages, leading to CXCL2 production and neutrophil recruitment.
Ogawa K, Aoki T, Kaneko T, Wang H, Shimizu D, Katsumi D, Kojima I, Tanaka H, Motoyoshi K, Ozaki K, Nishimura K, Iinuma T, Takami M, Motohashi S.   +13 more
europepmc   +2 more sources