Results 131 to 140 of about 25,964,170 (220)

Slow calcium removal contributes to impaired lusitropic response to β‐adrenergic stimulation in HFpEF mice

The Journal of Physiology, EarlyView.
Abstract figure legend Heart failure with preserved ejection fraction (HFpEF) is the most common form of heart failure, yet major gaps remain in our understanding of its underlying mechanisms, disease progression and effective treatment strategies. Mice with HFpEF exhibited exercise intolerance and diastolic dysfunction in vivo, while isolated hearts ...
Tamzin Zawadzki, Diana S. Usai, Sif G. Kaad, Katrine H. Rasmussen, Mie S. Larsen, Jens C. B. Jacobsen, Morten B. Thomsen   +6 more
wiley   +1 more source

Continuous Imaging of the Cardiac Cycle Metabolism With Hyperpolarized [1‐13C]Pyruvate

NMR in Biomedicine, Volume 39, Issue 11, November 2026.
We present a continuous hyperpolarized 13C MRI framework for phase‐resolved imaging of myocardial metabolism throughout the entire cardiac cycle. By combining spectral‐spatial bicarbonate excitation with frequency‐shifted reconstruction of residual pyruvate signal, both metabolites are obtained from a single acquisition.
Mohsen Redda, Nikolaj Bøgh, Esben Søvsø Szocska Hansen, Uffe Kjærgaard, Rolf F. Schulte, Christoffer Laustsen   +5 more
wiley   +1 more source

Screening the Tox21 Compound Library for Chemicals That Stimulate the Adrenergic β1 Receptor. [PDF]

Chem Res Toxicol
Adesina PA, Zhang L, Sukhawanit C, Wood S, Zhao J, Li Z, Sakamuru S, Ferguson SS, Hsieh JH, Reif DM, Huang R, Xia M.   +11 more
europepmc   +1 more source

Cutaneous‐only hypersensitivity reaction presumed due to intravenous administration of atracurium in a dog

Veterinary Record Case Reports, Volume 14, Issue 4, November 2026.
Summary There are limited case reports of hypersensitivity reactions to neuromuscular blocking agents (NMBAs) in veterinary species, and none describe cutaneous‐only signs. This case report describes a Grade 1 cutaneous‐only hypersensitivity reaction to atracurium in a 7‐year‐old dog undergoing general anaesthesia for cataract surgery with bilateral ...
Kar Yee Phoon, Rob Ward
wiley   +1 more source

Ephedrine for Reducing Onset Time of Rocuronium in Elderly Patients: A Randomised Study

Acta Anaesthesiologica Scandinavica, Volume 70, Issue 10, November 2026.
ABSTRACT Introduction Onset time of rocuronium is prolonged in elderly patients compared to younger patients. Ephedrine reduces onset time of rocuronium in younger adults, but in elderly patients, the effect of ephedrine on onset time of rocuronium has not been investigated.
Matias Vested, Magnus Fuhr Hovind, Tatiana Nielsen, Sarah Sofie Wadland, Mikkel Helmuth Jensen, Andreas Rodriguez Slente, Karl Peter Damgaard Madsen, Kamilla Skovmand, Fabio Rosa, Charlotte Albrechtsen, Lars Simon Rasmussen   +10 more
wiley   +1 more source

β2-adrenergic receptor stimulation drives differentiation of human adipose-derived mesenchymal stem cells into beige adipocytes. [PDF]

Adipocyte
Maekawa K, Yokoyama F, Tsutsumi R, Tateishi A, Maeda A, Tateishi N.   +5 more
europepmc   +1 more source

Estrogen Receptor Beta Isoforms Interplay Integrates Nuclear and Extra‐Nuclear Signaling to Modulate Human Granulosa Cell Growth

The FASEB Journal, Volume 40, Issue 19, 15 October 2026.
Working model of ERβ isoform signaling in human granulosa cells. Upon E2 binding, ERβ1 activates ERE‐dependent transcription and represses AP‐1 activity through Jun/Fos interactions. In contrast, ERβ2, ERβ4, and ERβ5 lack E2 binding and ERE activity but promote AP‐1‐dependent transcription and counteract ERβ1 repression, including after phosphorylation
Clémentine Marie, Inza‐Noor Baskaran, Raphaël Corre, Anne Mayeur, Michaël Grynberg, Guillaume Chevreux, David L'Hôte, Joëlle Cohen‐Tannoudji, Stéphanie Chauvin   +8 more
wiley   +1 more source

Drug-induced hyperglycemia in obstetrics: key offending drugs, mechanisms, and practical management. [PDF]

Front Pharmacol
Xu J, Nguyen TN, Liu T, Jiang F, Zhao X, Qin S, Yin J.   +6 more
europepmc   +1 more source

Melatonin Levels in 89 Individuals With Smith Magenis Syndrome

American Journal of Medical Genetics Part A, Volume 200, Issue 10, Page 2260-2272, October 2026.
ABSTRACT In patients with Smith–Magenis syndrome (SMS), an inverted circadian rhythm of melatonin (MT) contributes to the sleep disturbance. Standard treatment of sleep disturbance with MT often leads to extremely high daytime MT levels, resulting in even more sleep disorders. We therefore retrospectively evaluated the MT data of 89 SMS patients.
Wiebe Braam, Ann C. M. Smith
wiley   +1 more source

Sex- and Age-Specific Trends in Prescriptions of Beta-3 Agonists and Anticholinergics in Japan: A Nationwide Prescription Database Study. [PDF]

Low Urin Tract Symptoms
Yokoyama M, Onuki A, Koshi K, Tsukahara S, Negami H, Shiba K, Kato Y, Kojima A, Kato D, Amemiya T, Nenohi T, Urushibara M, Fujiwara M, Asano T, Kano H, Ishizaka K.   +15 more
europepmc   +1 more source