Results 131 to 140 of about 23,778 (225)

Finn Waagstein and the paradigm shift in the treatment of heart failure with β-adrenergic receptor antagonists ('β-blockers'). [PDF]

Naunyn Schmiedebergs Arch Pharmacol
Lorenz K, Ravens U.
europepmc   +1 more source

Mechanisms underlying local Ca2+ signalling differences between right and left atrial myocytes at normal and increased frequencies

The Journal of Physiology, EarlyView.
Abstract figure legend Left atrial myocytes have TAT‐associated faster Ca2+ release but are more prone to maladaptation at higher frequencies due to weaker peripheral SR Ca2+ uptake and smaller trigger Ca2+ current. Abstract Changes in heart rate affect Ca2+ signalling and contractility in ventricular muscle, but the effects on atrial Ca2+ signalling ...
Joon‐Chul Kim, Hieu Trong Huynh, Phuong Kim Luong, Tran Nguyet Trinh, Yixuan Wu, Eleonora Grandi, Sun‐Hee Woo   +6 more
wiley   +1 more source

The impact of new tetralogy drugs on ventricular remodeling in heart failure patients: a systematic review and network meta-analysis. [PDF]

BMC Cardiovasc Disord
Wang XW, Li H, Wang GQ, Sheng YN, Wang X, Pan H, Wang ZH, Zhang W, Shang YY, Zhong M.   +9 more
europepmc   +1 more source

NAD replenishment restores mitochondrial function and thermogenesis in the brown adipose tissue of mice with obesity

The Journal of Physiology, EarlyView.
Abstract figure legend A high‐fat diet (HFD) induces brown adipose tissue (BAT) whitening, mitochondrial dysfunction (damaged cristae, fragmentation), reduced NAD+ levels and impaired thermogenesis, leading to lower energy expenditure and metabolic inflexibility.
Renata R. Braga, Matheus B. Rocha, Ana P. Morelli, Raul G. da Costa, Marcelo A. S. Mori, Adelino S. R. da Silva, José R. Pauli, Dennys E. Cintra, Eduardo R. Ropelle   +8 more
wiley   +1 more source

The effect of sex on the isolated and combined α- and β-adrenergic control of blood flow during handgrip in adults at high altitude: An exploratory study. [PDF]

Physiol Rep
Maier LE, Vanden Berg ER, Simpson L, Ewalts M, Foster K, Baylis J, Gasho C, Macleod D, van Diepen S, Anholm J, Lawley J, Ainslie PN, Gibbons TD, Stembridge M, Moore J, Steinback CD.   +15 more
europepmc   +1 more source

14‐3‐3 proteins: Regulators of cardiac excitation–contraction coupling and stress responses

The Journal of Physiology, EarlyView.
Abstract figure legend 14‐3‐3 protein interactions in cardiac regulation. Schematic representation of 14‐3‐3 binding partners in excitation–contraction coupling, transcriptional regulation/development and stress response pathways. Asterisks indicate targets where the exact 14‐3‐3 binding site is unknown.
Heather C. Spooner, Rose E. Dixon
wiley   +1 more source

Pharmacological interventions targeting β-adrenoceptors in colorectal cancer: an evolving paradigm. [PDF]

Inflammopharmacology
Ghosn A, Bassam K, Al Zein M, Nasser SA, Pintus G, Eid AH.   +5 more
europepmc   +1 more source

Deciphering pro‐arrhythmogenic mechanisms of EPAC in human atrial cardiomyocytes

The Journal of Physiology, EarlyView.
Abstract figure legend This study aimed to investigate the effect of exchange proteins directly activated by cAMP (EPAC) on the regulation of human atrial cardiomyocyte electrophysiology and their potential involvement in the onset of atrial fibrillation (AF).
Arthur Boileve, Margaux Aize, Maximin Détrait, Laura Brard, Adrien Leboyer, Pierre‐Antoine Dupont, Alexandre Lebrun, Vladimir Saplacan, Christophe Simard, Fabien Brette, Frank Lezoualc'h, Laurent Sallé   +11 more
wiley   +1 more source

A Systematic Review: Efficacy of Different Intraocular Pressure-Lowering Agents in Black Individuals. [PDF]

Cureus
Murugan R, Murugan V, Agarwal PK.
europepmc   +1 more source

Computational modelling of cardiac fibroblast signalling reveals a key role for Ca2+ in driving atrial fibrillation‐associated fibrosis

The Journal of Physiology, EarlyView.
Abstract figure legend A pre‐existing fibroblast signalling model was enhanced by integrating atrial‐specific components and reactions linked to atrial fibrosis and atrial fibrillation (AF). The analysis highlights the central role of Ca2⁺ signalling in driving profibrotic responses to AF‐relevant stimuli, angiotensin‐II and transforming growth factor ...
Najme Khorasani, Haibo Ni, Jeffrey J Saucerman, Dobromir Dobrev, Stefano Morotti, Eleonora Grandi   +5 more
wiley   +1 more source