Results 181 to 190 of about 19,951 (230)

Propranolol Reduces Parkinson's Tremor and Inhibits Tremor‐Related Activity in the Motor Cortex: A Placebo‐Controlled Crossover Trial

Annals of Neurology, Volume 97, Issue 4, Page 741-752, April 2025.
Objective Parkinson's disease (PD) resting tremor is thought to be initiated in the basal ganglia and amplified in the cerebello‐thalamo‐cortical circuit. Because stress worsens tremor, the noradrenergic system may play a role in amplifying tremor. We tested if and how propranolol, a non‐selective beta‐adrenergic receptor antagonist, reduces PD tremor ...
Anouk van der Heide, Maaike Wessel, Danae Papadopetraki, Dirk E.M. Geurts, Teije H. van Prooije, Frank Gommans, Bastiaan R. Bloem, Michiel F. Dirkx, Rick C. Helmich   +8 more
wiley   +1 more source

The causal relationship between antihypertensive drugs and depression: a Mendelian randomization study of drug targets. [PDF]

Front Endocrinol (Lausanne)
Yang Z, Li J, Huang P, Li Z, He J, Cai D, Lai Y.   +6 more
europepmc   +1 more source

Propranolol: A Promising Therapeutic Avenue for Classic Kaposi Sarcoma. [PDF]

Dermatol Pract Concept
Genedy RM, Owais M, El Sayed NM.
europepmc   +1 more source

Mechanisms of Lipid‐Associated Macrophage Accrual in Metabolically Stressed Adipose Tissue

BioEssays, Volume 47, Issue 4, April 2025.
Intermittent fasting (IF) exacerbates lipid‐associated macrophage (LAM) accrual in adipose tissue of obese mice via an adipocyte p53‐dependent mechanism. Possible adipocyte‐derived, IF‐mediated signals for monocyte recruitment and macrophage differentiation in the context of weight cycling include apoptotic or lipid/metabolite signals, DAMPs ...
Isabel Reinisch, Sarah Enzenhofer, Andreas Prokesch   +2 more
wiley   +1 more source

Deep learning-based discovery of compounds for blood pressure lowering effects. [PDF]

Sci Rep
Li R, Wu T, Xu X, Duan X, Wang Y.
europepmc   +1 more source

Perioperative Management Challenges in Silent Pheochromocytoma: A Case Report and Literature Review

Clinical Case Reports, Volume 13, Issue 4, April 2025.
ABSTRACT Silent pheochromocytomas, frequently misdiagnosed as nonfunctioning adrenal adenomas, carry a high risk of perioperative hemodynamic instability. This case underscores the importance of thorough preoperative biochemical screening, proactive anesthetic strategies, and continuous intraoperative monitoring.
Kai Lin, Xuan Li, Tian Guo, Haixing Zhong   +3 more
wiley   +1 more source

Efficacy of β-Blockers in Decreasing Mortality in Sepsis and Septic Shock Patients: A Systematic Review. [PDF]

Cureus
Perala A, Wishart AV, Hamouda RK, Elsaady E, Aslam MR, Khan S.   +5 more
europepmc   +1 more source

p21‐Activated Kinase 1 (Pak1) as an Element in Functional and Dysfunctional Interplay Among the Myocardium, Adipose Tissue, and Pancreatic Beta Cells

Comprehensive Physiology, Volume 15, Issue 2, April 2025.
Pak1 regulates cardiac function, adipose tissue metabolism, and pancreatic β‐cell survival and function. Inflammation, oxidative stress, and Hippo signaling link Pak1 dysfunction across these tissues. Pak1 activators hold promise as potential therapeutic interventions. Images were created with a licensed version of BioRender.com.
Paola C. Rosas, R. John Solaro
wiley   +1 more source

Genetic inactivation of the β1 adrenergic receptor prevents cerebral cavernous malformations in zebrafish. [PDF]

Elife
Li W, McCurdy S, Lopez-Ramirez MA, Lee HS, Ginsberg MH.   +4 more
europepmc   +1 more source