Results 181 to 190 of about 24,128 (225)

Mechanisms reducing parasympathetic activity in chronic hypoxia

The Journal of Physiology, EarlyView.
Abstract figure legend Parasympathetic activity is reduced in chronic hypoxia, but the underlying mechanism(s) are unclear. Using β‐adrenergic blockade to isolate parasympathetic control of heart rate at sea level and after 9‐12 days at high altitude, we investigated whether (i) chemoreflex activation, (ii) increased pulmonary ventilation and/or (iii ...
Lauren E. Maier, Andrew Douglas, Katharine Foster, Elliott J. Jenkins, Liam D. Corr, Peter Rasmussen, James Anholm, Travis D. Gibbons, Phil N. Ainslie, Mike Stembridge, Christoph Siebenmann   +10 more
wiley   +1 more source

Neuro-immune crosstalk in breast cancer: molecular mechanisms from stress signals to immune escape. [PDF]

Front Immunol
Ni G, Qian N, Jiang Y, Tian R, Huang T, Li S.   +5 more
europepmc   +1 more source

Extracellular ionic concentration modulates arrhythmias in a simulated population of human ventricular myocytes with long QT syndrome type 3

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic illustrating the in silico study pipeline. A total of 50,000 virtual myocytes were generated, which were then filtered to 7093 myocytes that fit experimentally constrained biomarkers for physiological electrical and calcium behaviour under wild‐type conditions.
Katherine Flannery, Jacob A. Miller, Steven Poelzing, Seth H. Weinberg   +3 more
wiley   +1 more source

Systematic evaluation of Tox21 compounds that target β-adrenergic receptors and their role in cardiotoxicity. [PDF]

Toxicol Appl Pharmacol
Luo X, Zhang L, Sakamuru S, Adesina PA, Zhao J, Xia M, Xu T, Ngan DK, Travers J, Wood S, Sukhawanit R, Garrison A, Klumpp-Thomas C, Ferguson SS, Zhu H, Hall MD, Reif DM, Huang R.   +17 more
europepmc   +1 more source

On the adaptive significance of group III/IV muscle afferent feedback for the cardiovascular response during sustained locomotion in humans

The Journal of Physiology, EarlyView.
Abstract figure legend Group III/IV leg muscle afferent feedback has previously been recognized as an important determinant of the cardiovascular response to exercise lasting <5 min. Here we demonstrate that the activity of these neurons is crucial in regulating central and peripheral haemodynamic responses during steady state exercise of longer ...
D. Iannetta, F. G. Laginestra, T. S. Thurston, R. H. Jenkinson, J. Chang, H.‐Y. Wan, R. M. Broxterman, J. C. Weavil, M. Amann   +8 more
wiley   +1 more source

Oestrogen receptors regulate vascular β₁- and β₃-adrenoceptor expression and shape sex-specific adrenergic control of vascular tone. [PDF]

Pflugers Arch
Riedel K, Deussen A, Zatschler B, Hentsche C, Müller B, Speier S, Reeps C, Tugtekin SM, Matschke K, Kopaliani I.   +9 more
europepmc   +1 more source

Regional electrical differences and arrhythmia in the rat atria: Role of sympathetic nerve distribution and function

The Journal of Physiology, EarlyView.
Abstract figure legend Atrial fibrillation commonly develops in the left atrium and pulmonary veins (PVs), and can be triggered by sympathetic nerve activity. Here, we examined regional atrial differences in sympathetic nerve distribution and function in the rat.
James Saleeb‐Mousa, Manish Kalla, Neil Herring, Christopher O'Shea, Andrew M. Coney, Keith L. Brain, Andrew P. Holmes   +6 more
wiley   +1 more source

Beat‐to‐beat variability of ventricular repolarization reveals sex‐specific instability and proarrhythmic risk

The Journal of Physiology, EarlyView.
Abstract figure legend A mechanistic framework linking sex‐dependent dynamical instability to proarrhythmic risk. Sex‐specific human ventricular models show that upstream modulators, including biological sex, hormones, drugs and heart disease, promote steeper APD restitution in female than male and enhance dynamical instability.
Daisuke Sato, Lorenzo Santini, Raffaele Coppini, Eleonora Grandi   +3 more
wiley   +1 more source

Structural Mechanism of an Efficacy Photoswitch Targeting the β₂-adrenergic Receptor. [PDF]

Angew Chem Int Ed Engl
Stipp R, Bertrand Q, Trabuco M, Duran-Corbera A, Ignazzitto MT, Glover H, Stierli F, Catena J, Carrillo M, Hartmann S, Seidel HP, Mulder M, Mason T, Kondo Y, Wranik M, Appleby M, Sager C, Sierra R, Gate G, Schleissner P, Cheng X, Weinert T, Cheng R, Mous S, Beale JH, Kepa M, Llebaria A, Hennig M, Rovira X, Standfuss J.   +29 more
europepmc   +1 more source

Why Consider Separate Adherence Domains? Data From a 12‐Week Workplace Lifestyle Program in Taiwan: A Single‐Arm Real‐World Cohort Study

Lifestyle Medicine, Volume 7, Issue 4, October 2026.
ABSTRACT Background Workplace lifestyle programs are increasingly used for early cardiovascular–kidney–metabolic prevention but are commonly evaluated as whole packages. Whether distinct adherence domains within a multimodal program are associated with different short‐term health responses remains unclear.
Hao Hsu, Wenling Hsu, Wan‐Ming Chen, Chun‐Sheng Ho, Yi‐Chiun Yang, Szu‐Yuan Wu   +5 more
wiley   +1 more source