Results 281 to 290 of about 115,479 (330)

Disruption of the l‐DOPA Receptor Gpr143/OA1‐Gene in Mice Creates a Unique Mixed Psychosis‐Like Phenotype

open access: yesNeuropsychopharmacology Reports, Volume 46, Issue 1, March 2026.
We analyzed the behavior of GPR143 gene‐deficient mice. GPR143‐KO mice displayed a mixed psychiatric phenotype. GPR143 may play a role in mesolimbic and mesocortical functions underlying sensory gating, reward, social hierarchy, cognition, and emotional regulation. ABSTRACT GPR143, originally identified as the gene product of ocular albinism 1 (OA1), a
Yoshio Goshima   +9 more
wiley   +1 more source

Drug Repositioning in Doxorubicin-Induced Cardiotoxicity Protection. [PDF]

open access: yesInt J Mol Sci
Kosić M   +3 more
europepmc   +1 more source

Impaired adrenergic regulation of Kv channels underlies LC hyperactivity and early‐onset sleep disruption in AD‐like amyloidogenic mice

open access: yesAlzheimer's &Dementia, Volume 22, Issue 2, February 2026.
Abstract INTRODUCTION Sleep–wake disturbances frequently occur at early stages of Alzheimer's disease (AD) and accelerate disease progression, but the underlying neural mechanisms are not fully understood. METHODS We examined sleep–wake behavior and locus coeruleus (LC) activity in young 5xFAD mice using electrophysiology and pharmacological approaches
Yi‐Ci Zhang   +5 more
wiley   +1 more source

The Discovery of α-Adrenoceptor Antagonists as a Potential New Treatment Option for Uveal Melanoma. [PDF]

open access: yesBiomolecules
He Y   +5 more
europepmc   +1 more source

Systematic evaluation of Tox21 compounds that target β-adrenergic receptors and their role in cardiotoxicity. [PDF]

open access: yesToxicol Appl Pharmacol
Luo X   +17 more
europepmc   +1 more source

Heat Therapy: Targeting Health, Disease, and Disability

open access: yesComprehensive Physiology, Volume 16, Issue 1, February 2026.
The predominance of evidence suggests heat therapy has an impact on all aspects of health and performance, but the drivers of that improvement, the extent to which they are improved, and the specific populations in which improvements manifest are far from completely understood.
Rauchelle E. Richey   +5 more
wiley   +1 more source

Acute Hypoxia Decreases Maximum Fat Oxidation Rate During Step Incremental Exercise Normalized to Respiratory Compensation Point

open access: yesEuropean Journal of Sport Science, Volume 26, Issue 2, February 2026.
ABSTRACT Whether fat oxidation (FATox) is altered during exercise in hypoxia remains equivocal due to differences in experimental protocols. Furthermore, to date no investigation has reported the effect of hypoxia on maximal fat oxidation rate (MFO).
Youmna Elsayed Hassanein   +3 more
wiley   +1 more source

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