Hypertension and Male Fertility [PDF]
The World Journal of Men's Health, 2017 As the age of paternity rises in the developed world, issues of chronic disease may affect prospective fathers. Given the high prevalence of hypertension, researchers have begun to explore the relationship between hypertensive disease and male fertility.
David Guo +3 more
doaj +1 more source
Functional selectivity of GPCR-directed drug action through location bias. [PDF]
, 2017 G-protein-coupled receptors (GPCRs) are increasingly recognized to operate from intracellular membranes as well as the plasma membrane. The β 2 -adrenergic GPCR can activate G s -linked cyclic AMP (G s -cAMP) signaling from endosomes.
Conti, Marco +6 more
core +3 more sources
Comparison of Adrenergic Beta-receptor Antagonists in Angina Pectoris
British medical journal, 1973 The symptomatic, electrocardiographic, and circulatory effects of intravenous and oral preparations of propranolol, oxprenolol, and practolol were compared in 16 patients with uncomplicated angina pectoris precipitated by exertion.
U. Thadani +5 more
semanticscholar +1 more source
A selective alpha1D-adrenoreceptor antagonist inhibits human prostate cancer cell proliferation and motility "in vitro" [PDF]
, 2016 The progression of prostate cancer (PC) to a metastatic hormone refractory disease is the major contributor to the overall cancer mortality in men, mainly because the conventional therapies are generally ineffective at this stage. Thus, other therapeutic
Bolchi, Cristiano +8 more
core +2 more sources
The Principles of Ligand Specificity on beta-2-adrenergic receptor
Scientific Reports, 2016 G protein-coupled receptors are recognized as one of the largest families of membrane proteins. Despite sharing a characteristic seven-transmembrane topology, G protein-coupled receptors regulate a wide range of cellular signaling pathways in response to
H. C. S. Chan, S. Filipek, Shuguang Yuan
semanticscholar +1 more source
Respiratory Research, 2021 Background Beta-blocker therapies for cardiovascular comorbidities are often withheld in patients with chronic obstructive pulmonary disease (COPD) due to potential adverse effects on airway obstruction.
Kenneth R. Chapman +6 more
doaj +1 more source
Cognitive Function and Urologic Medications for Lower Urinary Tract Symptoms [PDF]
International Neurourology Journal, 2020 Special considerations should be made when selecting medications for the treatment of lower urinary tract symptoms (LUTS) in older patients especially those over 65 years old.
Yeon Joo Kim, Bum Sik Tae, Jae Hyun Bae
doaj +1 more source
ENDOGENOUS BETA-ADRENERGIC RECEPTOR ANTAGONISTS (EBARA) IN HEALTH AND DISEASE [PDF]
, 2017 Data accumulated in investigations under in vivo and in vitro conditions confirm author's concept about the existence of EBARA, certain endogenous biologically active substances in a healthy and pathologically altered organism when no betaadrenergic ...
Temnyalov, N.
core +2 more sources
A M A Archives of Ophthalmology, 2010 OBJECTIVE To perform a meta-analysis to estimate the intraocular pressure (IOP)-lowering efficacy and safety of alpha(2)-adrenergic agonists (AAs), beta-adrenergic antagonists (BBs), and topical carbonic anhydrase inhibitors (TCAIs) when used in ...
A. Tanna +3 more
semanticscholar +1 more source
Involvement of Noradrenergic Neurotransmission in the Stress- but not Cocaine-Induced Reinstatement of Extinguished Cocaine-Induced Conditioned Place Preference in Mice: Role for β-2 Adrenergic Receptors [PDF]
, 2010 The responsiveness of central noradrenergic systems to stressors and cocaine poses norepinephrine as a potential common mechanism through which drug re-exposure and stressful stimuli promote relapse.
A Dzung Lê +86 more
core +3 more sources