Results 251 to 260 of about 136,170 (301)
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Beta-adrenergic blocker withdrawal
The American Journal of Cardiology, 1987Abrupt withdrawal of long-term beta-blocker therapy in patients with angina may be associated with unstable angina and myocardial infarction. It appears that an "overshoot" in heart rate from pretreatment values occurs, which increases myocardial oxygen demand. This increase in heart rate may be secondary to increased beta receptor numbers or increased
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Thymoxamine hydrochloride: An alpha-adrenergic blocker
Survey of Ophthalmology, 1980Thymoxamine is an alpha-adrenergic blocking agent which works by competitive antagonism of norepinephrine. It is the only alpha-adrenergic blocker available which has tolerable side effects when used as an ophthalmic solution. When used as a 0.5% solution it consistently produces miosis without affecting the intraocular pressure or the ciliary muscle ...
M, Wand, W M, Grant
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An irreversible blocker for the β-adrenergic receptor
Biochemical and Biophysical Research Communications, 1976Abstract New reversible blockers for the β-adrenergic receptor have been synthesized. All the compunds possess free amine(s) residues which have been bromoacetylated. The N-bromoacetyl derivatives were also found to be potent β-blockers. One of these bromoacetyl derivatives: N-(2-hydroxy-3-naphthoxypropyl)-N′-bromoacetyl-ethylenediamine is shown to ...
D, Atlas, A, Levitzki
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Considerations in β-Adrenergic Blocker Evaluation
Archives of General Psychiatry, 1984To the Editor.— Two recent articles have reported on the use of β-adrenergic blocking agents in the treatment of panic disorder. Gorman et al 1 reported on the effects of intravenously (IV) administered propranolol hydrochloride in lactate-induced panic in patients with preexisting panic disorders, and Noyes et al 2 compared the efficacy of diazepam ...
S, Yudofsky, J M, Silver
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Pharmacokinetics of the β-Adrenergic Blocker Sotalol in Dogs
Journal of Pharmaceutical Sciences, 1973The time course of absorption, distribution, and excretion of the β-blocker sotalol was studied in three unanesthetized dogs at three dosage levels of 1, 2, and 4 mg./kg. i.v. and 2, 4, and 8 mg./kg. p.o. The drug was assayed in body fluids and excreta by a spectrophotofluorometric method and by counting of tritiated drug. Unchanged sotalol is excreted
K, Schnelle, E R, Garrett
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Medical Clinics of North America, 1988
beta-Adrenergic blocking drugs have been available for several years to treat ischemic heart disease and other cardiovascular and noncardiovascular disorders. There are multiple drugs in this class with various pharmacodynamic and pharmacokinetic properties that may be important in specific clinical situations and in avoiding certain adverse reactions.
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beta-Adrenergic blocking drugs have been available for several years to treat ischemic heart disease and other cardiovascular and noncardiovascular disorders. There are multiple drugs in this class with various pharmacodynamic and pharmacokinetic properties that may be important in specific clinical situations and in avoiding certain adverse reactions.
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Synthetic gastrin as a dual adrenergic blocker
The American Journal of Digestive Diseases, 1971A gastrin-like peptide, pentagastrin, was found to exhibit anα- as well asβ-adrenergic blockade on various isolated preparations in vitro. The block appears to be competitive in nature. However, since the concentrations required to produce the block were well above the physiologic or hormonal range, the significance of the blockade is not clear at ...
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The Medical clinics of North America, 1988
alpha-Adrenergic blockers are important drugs in the treatment of hypertension and other cardiovascular and noncardiovascular disorders. The ability to selectively block alpha-receptor subtypes provides a greater margin of safety and efficacy for these drugs.
W H, Frishman, S, Charlap
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alpha-Adrenergic blockers are important drugs in the treatment of hypertension and other cardiovascular and noncardiovascular disorders. The ability to selectively block alpha-receptor subtypes provides a greater margin of safety and efficacy for these drugs.
W H, Frishman, S, Charlap
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Beta-adrenergic blockers as cardioprotective agents
The American Journal of Cardiology, 1992The evidence supporting and describing cardioprotective effects of beta-adrenergic blocker treatment is surveyed. Details of the many studies that individually and collectively document the ability of long-term and acute beta-blocker therapy to reduce overall mortality, sudden cardiovascular death, and nonfatal reinfarction in patients surviving or ...
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Trial of an adrenergic beta-blocker in the menopause
Psychosomatics, 1984Abstract Timolol was compared with placebo in a double-blind randomized crossover study in 54 women affected by menopausal symptoms. The results were assessed with Blatt's Menopausal Index, modified so that it could be subdivided into vasomotor, psychogenic, and sexual symptoms. There was significant relief of vasomotor symptoms with both timolol and
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