Treatment Selection and Prioritization for the EJS ACT‐PD MAMS Trial Platform
Movement Disorders, EarlyView.Abstract Background There are currently no disease‐modifying therapies (DMTs) registered for Parkinson's disease (PD). The Edmond J. Safra Accelerating Clinical Trials in Parkinson Disease (EJS ACT‐PD) initiative will expedite clinical assessment of putative DMTs through a multi‐arm multistage (MAMS) trial, testing several treatments against a common ...
Cristina Gonzalez‐Robles +29 more
wiley +1 more source
Light‐Activated Pharmacological Tools for Exploring the Cholinergic System
Medicinal Research Reviews, EarlyView.ABSTRACT Cholinergic transmission plays a critical role in both the central and peripheral nervous systems, affecting processes such as learning, memory, and inflammation. Conventional cholinergic drugs generally suffer from poor selectivity and temporal precision, leading to undesired effects and limited therapeutic efficacy. Photopharmacology aims to
Alessio Colleoni +5 more
wiley +1 more source
Adrenergic Receptors Within the Cardiovascular System [PDF]
, 1963 Neil C. Moran
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Recent Developments in the Optical Control of Adrenergic Signaling
Medicinal Research Reviews, EarlyView.ABSTRACT Adrenoceptors (ARs) play a vital role in various physiological processes and are key therapeutic targets. The advent of optical control techniques, including optogenetics and photopharmacology, offers the potential to modulate AR signaling with precise temporal and spatial resolution. In this review, we summarize the latest advancements in the
Shuang Shi +4 more
wiley +1 more source
Muscle &Nerve, EarlyView.ABSTRACT Introduction/Aims The true frequency and severity of myasthenia gravis (MG) exacerbation associated with the usage of fluoroquinolone and macrolide antibiotics remain unknown. We aimed to investigate the association between ciprofloxacin, levofloxacin, azithromycin, and MG exacerbation.
Sanem Pinar Uysal +3 more
wiley +1 more source
A Scoping Review of the Oral Treatment Options for the Management of Detrusor Sphincter Dyssynergia
Neurourology and Urodynamics, EarlyView.ABSTRACT Background Adult neurogenic lower urinary tract dysfunction may be associated with detrusor sphincter dyssynergia (DSD). Given the sparsity of the literature and the absence of official guidelines regarding the use of oral medications in the management of DSD, this scoping review aims to critically assess the available evidence to guide future
Angélique Tousignant +4 more
wiley +1 more source
The role of adrenergic receptor polymorphisms in heart failure
Brazilian Journal of Medical and Biological Research, 2006 The main function of the cardiac adrenergic system is to regulate cardiac work both in physiologic and pathologic states. A better understanding of this system has permitted the elucidation of its role in the development and progression of heart failure.
A. Biolo +6 more
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Adrenergic Receptors and the Secretion of Glucagon and Insulin from the Isolated, Perfused Canine Pancreas [PDF]
, 1973 Johan Iversen
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Pathophysiology of Urethral Instability: Dysfunction of Smooth Urethral Musculature
Neurourology and Urodynamics, EarlyView.ABSTRACT Aims The aim of this study is to elucidate the pathophysiological mechanisms of urethral instability by analyzing and comparing cystometric data from a female individual with urethral instability and another with normal micturition. Methods Data were collected from a previous study measuring urethral pressure at three distinct points within ...
Pieter L. Venema +4 more
wiley +1 more source
Ectopic beta-adrenergic receptor binding sites. possible molecular basis of aberrant catecholamine responsiveness of an adrenocortical tumor adenylate cyclase. [PDF]
, 1977 L T Williams +2 more
openalex +1 more source