Results 291 to 300 of about 2,542,862 (407)

Evaluating biased agonism of glucagon‐like peptide‐1 (GLP‐1) receptors to improve cellular bioenergetics: A systematic review

open access: yesDiabetes, Obesity and Metabolism, EarlyView.
Abstract Glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs) are highly effective antidiabetic and anti‐obesity agents. Recent development and optimisation of these agents includes biased agonism (selective activation of a downstream signalling pathway) of the GLP‐1 receptor, which has demonstrated greater weight‐lowering effects and improved insulin
Sabrina Wong   +4 more
wiley   +1 more source

β3-Adrenergic receptor overexpression in cardiomyocytes preconditions mitochondria to withstand ischemia-reperfusion injury. [PDF]

open access: yesBasic Res Cardiol
Fernández-Tocino M   +15 more
europepmc   +1 more source

Autoimmunity in MASLD: Focus on autoantibodies, anti‐apolipoprotein A1 IgG and G protein‐coupled receptors

open access: yesEuropean Journal of Clinical Investigation, EarlyView.
This review outlines the potential role of anti‐GPCR autoantibodies in MASLD/MASH, given their involvement in a wide range of diseases and their possible contribution to MASLD/MASH pathophysiology. We also focused on anti‐ApoA1 autoantibodies, sharing functional features with anti‐GPCR autoantibodies and have been shown to promote liver steatosis in ...
Sabrina Pagano   +3 more
wiley   +1 more source

Dobutamine improves haemodynamics and oxygen delivery in standing and isoflurane‐anaesthetised horses

open access: yesEquine Veterinary Journal, EarlyView.
Abstract Background Dobutamine is a first‐line therapy for hypotension in anaesthetised horses, but the effects on haemodynamic parameters in standing and anaesthetised horses are not well studied. Objectives To investigate the effects of dobutamine in escalating dosages on haemodynamic performance in awake and anaesthetised horses.
Emma B. Gorenberg   +4 more
wiley   +1 more source

Role of the β2-adrenergic receptor in podocyte injury and recovery. [PDF]

open access: yesPharmacol Rep
Arif E   +6 more
europepmc   +1 more source

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