Results 41 to 50 of about 125,726 (303)

ß-adrenergic receptor blocker poisoning

, 2007
ß-adrenergic receptor blocking drugs are used in the treatment of hypertension, angina, myocardial infarction, cardiac dysrhythmia, cardiomyopathy, migraine headache, thyrotoxicosis, and glaucoma.
Dagmara Reingardienė
core   +1 more source

‐adrenergic receptor agonist and a muscarinic receptor antagonist inhibits detrusor overactivity induced by cold stress in spontaneously hypertensive rats [PDF]

, 2016
AimsThis study determined if combined treatment with the muscarinic receptor (MR) antagonist solifenacin and the (3)-adrenergic receptor (AR) agonist mirabegron could inhibit detrusor overactivity induced by cold stress in spontaneously hypertensive rats
Hitoshi Yokoyama, Osamu Ishizuka, Nagai, Takashi, Yokoyama, Hitoshi, Teruyuki Ogawa, Masaki Nakazawa, Tetsuya Imamura, Tomonori Minagawa, Minagawa, Tomonori, Nakazawa, Masaki, Saito, Tetsuichi, Ishizuka, Osamu, Tetsuichi Saito, Suzuki, Toshiro, Takashi Nagai, Toshiro Suzuki, Imamura, Tetsuya, Ogawa, Teruyuki   +17 more
core   +1 more source

DFT study of ligand binding in the β1 adrenergic receptor [PDF]

, 2021
This is an accepted manuscript of an article published by Elsevier in Computational and Theoretical Chemistry, available online: https://doi.org/10.1016/j.comptc.2021.113208 The accepted version of the publication may differ from the final published ...
Peterson, L. W., Peterson, Larryn W, Simons, M., Safarian, D., Megan Simons, Rebecca G. Evans, Cafiero, Mauricio, Simons, Megan, Daryna Safarian, Larryn W. Peterson, Evans, R. G., Mauricio Cafiero, Evans, Rebecca G, Safarian, Daryna   +13 more
core   +1 more source

Mechanical and Electrical Phenotype of hiPSC‐Cardiomyocytes on Fibronectin‐Based Hydrogels

Advanced Healthcare Materials, EarlyView.
We introduce fibronectin‐based PEG hydrogels with controlled rigidity to enable the culture of iPSC‐derived cardiomyocytes. These substrates offer an alternative to the current culture of these cells on fibronectin‐coated glass, providing enhanced structural and functional behavior. The system provides a more physiologically relevant platform to assess
Ana Da Silva Costa, Lineta Stonkute, Sara Trujillo, Mariana Azevedo Gonzalez Oliva, Francis Burton, Matthew J. Dalby, Oana Dobre, Godfrey Smith, Manuel Salmeron‐Sanchez   +8 more
wiley   +1 more source

Cellular Responses to Mechanical Cues Across Scales: From Fundamental Insights to Translational Potential

Advanced Healthcare Materials, EarlyView.
This review examines how cellular behavior is regulated by mechanical cues transmitted through soft biomaterials, from single‐cell mechanosensing to tissue‐level adaptation. It highlights why physiological relevance, rather than model complexity alone, is critical for translational mechanobiology and introduces a scoring framework linking material ...
Mathias Polz, Manuel P. Kainz, Niklas Haider, Theresa Rienmüller, Kerstin Lenk, Rupert Kargl, Michele Terzano, Gerhard Sommer, Gerhard A. Holzapfel, Julia Fuchs   +9 more
wiley   +1 more source

The NADPH oxidase NOX4 regulates redox and metabolic homeostasis preventing HCC progression

Hepatology, EarlyView., 2022
Loss of NOX4 in HCC tumor cells induces metabolic reprogramming in a Nrf2/MYC‐dependent manner to promote HCC progression. Abstract Background and Aims The NADPH oxidase NOX4 plays a tumor‐suppressor function in HCC. Silencing NOX4 confers higher proliferative and migratory capacity to HCC cells and increases their in vivo tumorigenic potential in ...
Irene Peñuelas‐Haro, Rut Espinosa‐Sotelo, Eva Crosas‐Molist, Macarena Herranz‐Itúrbide, Daniel Caballero‐Díaz, Ania Alay, Xavier Solé, Emilio Ramos, Teresa Serrano, María L. Martínez‐Chantar, Ulla G. Knaus, José M. Cuezva, Antonio Zorzano, Esther Bertran, Isabel Fabregat   +14 more
wiley   +1 more source

MD simulations of human beta2 adrenergic receptor

, 2022
100 ns MD simulations of the human beta2 adrenergic receptor(PDB ID: 3NY9 (Wacker et al., 2010)) without any ligands in ribbon view (Right) with a view of crystal with its ligands (inverse agonist)(left).
Ahmad Shahir Sadr (8882657)
core   +1 more source

Natural Products Inspired Scaffold Diversification Leads to Unnatural Molecular Warhead and Covalent Strategy to Modulating Protein Function through Electrophilic Bromine Transfer

Advanced Science, EarlyView.
We report a new thiolate‐reactive α,α‐gem‐dibromo lactam warhead that activates transcription factor Nrf2 and demonstrates anti‐inflammatory activities, which have implications in cancer, neurodegeneration, and cardiovascular diseases. RNA‐seq illuminated detailed transcriptional profiles, and chemical reactions with cysteine‐containing compounds ...
Beau R. Brummel, Sofia Kokkaliari, Qiwen Gao, Jinjing Chen, Larissa Costa de Almeida, Srinivasarao Tenneti, Derek A. Leas, Eli Levit, Lewis S. Alexander, Khalil A. Abboud, Pingrong Wei, Michael D. Cameron, James R. Rocca, Ranjala Ratnayake, Donna D. Zhang, Hendrik Luesch, Robert W. Huigens III   +16 more
wiley   +1 more source

Postural Orthostatic Tachycardia Syndrome Is Associated With Elevated G‐Protein Coupled Receptor Autoantibodies

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019
Background The etiology of postural orthostatic tachycardia syndrome (POTS) is yet to be established. The disorder is often misdiagnosed as chronic anxiety or a panic disorder because the autonomic failure in these patients is not severe.
William T. Gunning, Heather Kvale, Paula M. Kramer, Beverly L. Karabin, Blair P. Grubb   +4 more
doaj   +1 more source

Serum Activity Against G Protein–Coupled Receptors and Severity of Orthostatic Symptoms in Postural Orthostatic Tachycardia Syndrome

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2020
Background Postural orthostatic tachycardia syndrome (POTS) is characterized by excessive heart rate increase on standing and orthostatic intolerance. Previous data indicate autoimmune involvement.
Isabella Kharraziha, Jonas Axelsson, Fabrizio Ricci, Giuseppe Di Martino, Margaretha Persson, Richard Sutton, Artur Fedorowski, Viktor Hamrefors   +7 more
doaj   +1 more source